Patents by Inventor Matthew Mark Abelman

Matthew Mark Abelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
    Patent number: 6060462
    Abstract: This invention relates to electrophilic dipeptide analogs conjugated to an N,N-disubstituted .alpha.-amino acid as inhibitors of trypsin-like serine protease enzymes.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: May 9, 2000
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Robert Anthony Galemmo, Jr., Matthew Mark Abelman, Eugene Cruz Amparo, John Matthew Fevig, Robert Madara Knabb, William Henry Miller, Gregory James Pacofsky, Patricia Carol Weber, Joseph Cacciola
  • N-substituted glycine derivatives as enzyme inhibitors
    Patent number: 6025472
    Abstract: The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 15, 2000
    Assignee: Corvas International, Inc.
    Inventors: Matthew Mark Abelman, Todd Anthony Miller, Ruth Foelsche Nutt
  • Inhibitors of thrombosis
    Patent number: 5955576
    Abstract: This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 21, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Thomas Roy Webb, Matthew Mark Abelman, Daniel Andrew Pearson, Todd Anthony Miller
  • Arginine keto-amide enzyme inhibitors
    Patent number: 5869454
    Abstract: The present invention is directed to novel arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, described are methods of using these inhibitors as inhibitors of coagulation proteases and as therapeutic agents for disease states characterized by abnormal thrombus formation and/or disorders of the blood coagulation process. Further described herein are compounds useful as intermediates in the preparation of these compounds.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 9, 1999
    Assignee: Corvas International, Inc.
    Inventors: Thomas Roy Webb, Todd Anthony Miller, George Phillip Vlasuk, Matthew Mark Abelman
  • Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
    Patent number: 5770600
    Abstract: This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 23, 1998
    Assignee: Corvas International, Inc.
    Inventors: Matthew Mark Abelman, Robert John Ardecky, Ruth Foelsche Nutt
  • N-substituted glycine derivatives as enzyme inhibitors
    Patent number: 5696231
    Abstract: The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: December 9, 1997
    Assignee: Corvas International, Inc.
    Inventors: Matthew Mark Abelman, Todd Anthony Miller, Ruth Foelsche Nutt
  • Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
    Patent number: 5658939
    Abstract: This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: August 19, 1997
    Assignee: Corvas International Inc.
    Inventors: Matthew Mark Abelman, Robert John Ardecky, Ruth Foelsche Nutt