Patents by Inventor Matthew Morrow

Matthew Morrow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same
    Patent number: 11998598
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: June 4, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Matthew Morrow
  • ASSAYS AND METHODS FOR DETERMINING MICROBIAL RESISTANCE
    Publication number: 20240150850
    Abstract: Assays and methods for detecting resistance to beta-lactam antibiotics including detection of multiple ?-lactamase family specific gene targets by polymerase chain reaction or microarray. One or more kits including primers and/or probes for identification of ?-lactamase genes selected from the group consisting of one or more of the following: MOX-like, FOX-like, ACC-like, ACT/MIR-like, CMY-2-like, DHA-like, CTX-M-14-like, CTX-M-15-like, VIM-like, NDM-like, IMP-like, KPC-like, and OXA-48-like, OXA-51-like, OXA-143-like, OXA-58-like, OXA-23-like, OXA-24/40-like, TEM-like, and SHV-like. A kit may also include one or more primers and/or probes for the identification a non-beta lactamase gene family which confers antibiotic resistance, such as the MCR-1 gene.
    Type: Application
    Filed: June 9, 2023
    Publication date: May 9, 2024
    Inventors: Maria Torres-Gonzalez, Nancy Hanson, Joel Lechner, Stephanie Cossette, Cathy Scheer, Matthew R. Kreifels, Stacey Morrow, Christopher Connelly, Laura R. Porter, Randy Fowler
  • VACCINES AND IMMUNOTHERAPEUTICS USING IL-28 AND COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20210330784
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Application
    Filed: May 7, 2021
    Publication date: October 28, 2021
    Inventors: David B. Weiner, Matthew Morrow
  • VACCINES WITH INTERLEUKIN-33 AS AN ADJUVANT
    Publication number: 20210196818
    Abstract: Disclosed herein is a vaccine comprising an antigen and IL-33. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating cancer in a subject in need thereof. The methods may comprise administering the vaccine to the subject.
    Type: Application
    Filed: March 1, 2021
    Publication date: July 1, 2021
    Inventors: David Weiner, Daniel Villarreal, Matthew Morrow, Jian Yan
  • Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same
    Patent number: 11027009
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: June 8, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Matthew Morrow
  • Vaccines with interleukin-33 as an adjuvant
    Patent number: 10933130
    Abstract: Disclosed herein is a vaccine comprising an antigen and IL-33. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating cancer in a subject in need thereof. The methods may comprise administering the vaccine to the subject.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 2, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Daniel Villarreal, Matthew Morrow, Jian Yan
  • Vaccines with CD40 ligand as an adjuvant
    Patent number: 10925961
    Abstract: Disclosed herein is a vaccine comprising an antigen and CD40L. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: February 23, 2021
    Assignees: The Trustees of the University of Pennsylvania, INOVIO PHARMACEUTICALS. INC.
    Inventors: David Weiner, Matthew Morrow, Megan Wise
  • CLINICAL AND IMMUNOLOGIC BIOMARKERS FOR REGRESSION OF HIGH GRADE CERVICAL DYSPLASIA AND CLEARANCE OF HPV16 AND HPV18 INFECTION AFTER IMMUNOTHERAPY
    Publication number: 20200282042
    Abstract: Methods for treating a subject infected with human papillomavirus and accompanying symptoms comprise assessing a sample obtained from the patient after the treatment is administered to detect the presence or absence of biomarkers associated with lesion regression and/or clearance of the virus from the subject.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 10, 2020
    Inventors: Kimberly KRAYNYAK, Matthew MORROW, Albert J. SYLVESTER
  • VACCINES AND IMMUNOTHERAPEUTICS USING IL-28 AND COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20200268876
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 27, 2020
    Inventors: David B. Weiner, Matthew Morrow
  • Vaccines and immunotherapeutics using IL-28 and compositions and methods of using
    Patent number: 10646563
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Matthew Morrow
  • VACCINES AND IMMUNOTHERAPEUTICS USING IL-28 AND COMPOSITIONS AND METHODS OF USING
    Publication number: 20190076520
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Inventors: David B. Weiner, Matthew Morrow
  • VACCINES WITH INTERLEUKIN-33 AS AN ADJUVANT
    Publication number: 20180360958
    Abstract: Disclosed herein is a vaccine comprising an antigen and IL-33. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating cancer in a subject in need thereof. The methods may comprise administering the vaccine to the subject.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 20, 2018
    Inventors: David Weiner, Daniel Villarreal, Matthew Morrow, Jian Yan
  • INFLUENZA NUCLEIC ACID MOLECULES AND VACCINES MADE THEREFROM
    Publication number: 20180344842
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 6, 2018
    Inventors: David B. Weiner, Jian Yan, Matthew Morrow
  • Vaccines with interleukin-33 as an adjuvant
    Patent number: 10130705
    Abstract: Disclosed herein is a vaccine comprising an antigen and IL-33. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating cancer in a subject in need thereof. The methods may comprise administering the vaccine to the subject.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: November 20, 2018
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Daniel Villarreal, Matthew Morrow, Jian Yan
  • Influenza nucleic acid molecules and vaccines made therefrom
    Patent number: 10022434
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: July 17, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Jian Yan, Matthew Morrow
  • Vaccines with CD40 Ligand as an adjuvant
    Publication number: 20180085451
    Abstract: Disclosed herein is a vaccine comprising an antigen and CD40L. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: March 18, 2016
    Publication date: March 29, 2018
    Inventors: David Weiner, Matthew Morrow, Megan Wise
  • Vaccines having an antigen and interleukin-23 as an adjuvant
    Patent number: 9669091
    Abstract: Disclosed herein is a vaccine comprising an antigen and IL-23. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 6, 2017
    Assignees: INOVIO PHARMACEUTICALS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Jian Yan, Matthew Morrow, Bernadette Ferraro, David Hokey
  • Influenza Nucleic Acid Molecules And Vaccines Made Therefrom
    Publication number: 20160038584
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 11, 2016
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Jian Yan, Matthew Morrow
  • Vaccines Having an Antigen and Interleukin-23 As An Adjuvant
    Publication number: 20160030557
    Abstract: Disclosed herein is a vaccine comprising an antigen and IL-23. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 4, 2016
    Inventors: David WEINER, Matthew MORROW, Jian YAN, Bernadette FERRARO, David HOKEY
  • Influenza Nucleic Acid Molecules And Vaccines Made Therefrom
    Publication number: 20160022806
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Inventors: David Weiner, Jian Yan, Matthew Morrow