Patents by Inventor Matthew Moyle

Matthew Moyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6090916
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: July 18, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6087487
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: July 11, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6046318
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: April 4, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6040441
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: March 21, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 5955294
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: September 21, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Modified hookworm neutrophil inhibitors
    Patent number: 5919900
    Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: July 6, 1999
    Assignee: Corvas International, Inc.
    Inventors: Matthew Moyle, David L. Foster
  • Nematode-extracted anticoagulant protein
    Patent number: 5872098
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 16, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted anticoagulant protein
    Patent number: 5866543
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 2, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted anticoagulant protein
    Patent number: 5866542
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 2, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene n Laroche, Laurent Stephane Jespers, Yannick George Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted anticoagulant protein
    Patent number: 5863894
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 26, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Neutrophil inhibitors
    Patent number: 5789178
    Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 4, 1998
    Assignee: Corvas International, Inc.
    Inventors: Matthew Moyle, David L. Foster, George P. Vlasuk
  • Method of detecting neutophil inhibitory factor mimics
    Patent number: 5747296
    Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: May 5, 1998
    Assignee: Corvas International, Inc.
    Inventors: Matthew Moyle, David L. Foster, George P. Vlasuk
  • Neutrophil inhibitors
    Patent number: 5708141
    Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes, particularly of the genus Ancylostoma. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: January 13, 1998
    Assignee: Corvas International, Inc.
    Inventors: Matthew Moyle, David L. Foster, George P. Vlasuk
  • Beta-8 integrin subunit antibodies
    Patent number: 5635601
    Abstract: The cDNA encoding a novel beta integrin subunit, called the beta-8 integrin subunit, has been isolated from rabbit and human tissue and sequenced. Provided herein is nucleic acid sequence of the beta-8 integrin subunit useful as a diagnostic and in the recombinant preparation of beta-8 integrin subunit and alpha-beta integrin complexes. The beta-8 integrin subunit is used in the preparation and purification of antibodies thereto, and in diagnostic assays.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: June 3, 1997
    Assignee: Genentech, Inc.
    Inventors: Matthew Moyle, John W. McLean