Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing a first intravascular device having a distal portion with a concave side, inserting the first device into the vascular lumen, positioning the distal portion in the vascular wall, and orienting the concave side of the distal portion toward the vascular lumen.

Abstract: A sensing coil is provided for optically guiding counter-propagating light beams in a fiber optic gyroscope. The sensing coil comprises a plurality of layers of an optical fiber having a winding direction. The plurality of layers comprises inner layers, middle layers, and outer layers. The middle layers comprise first and second input ends configured to receive the counter-propagating light beams. At least one of the inner layers, middle layers, and outer layers is coupled with a different one of the inner layers, middle layers, and outer layers while maintaining the winding direction. A method is provided for winding an optical fiber, having first and second connecting ends, to form a sensing coil for a fiber optic gyroscope having a winding direction.

Abstract: Methods and apparatus are provided for a seal assembly that includes a first plate, a second plate, and compliant material. The first and second plates each have a first side, a second side, and a channel extending therebetween. The channel includes a first cross-sectional area proximate the first side and a second cross-sectional area that is proximate the second side. The first cross-sectional area is greater than a second cross-sectional area. The compliant material is disposed between the first and second plates and is at least partially within the first plate channel and the second plate channel.

Abstract: A fiber optic gyroscope (FOG) includes a sensing coil with a particular magnetic sensitivity magnitude and direction with respect to the geometric axis of the sensing coil. The FOG also includes a plurality of magnetic compensators. Each magnetic compensator is fabricated so as to have a particular magnetic sensitivity magnitude and direction, the magnitude being comparable to that of the sensing coil, with large tolerances relative to the magnitude and direction. The compensators are positioned relative to one another and to the sensing coil such that the combined magnetic sensitivities of the compensators cancel the magnetic sensitivity of the sensing coil.

Abstract: A magnetic shielding system for a fiber optic gyroscope is disclosed. The fiber optic gyroscope may have a sensing coil with a sensing axis. An exemplary magnetic shield may enclose the sensing coil and have a layer including a plurality of pieces connected at a seam. A portion of the seam may be substantially parallel to the sensing axis of the sensing coil. Also, the pieces may be connected together such that each piece has a portion of each of two sides and a wall of the magnetic shield. Additionally, multiple layers having orthogonal seams may be utilized with the magnetic shield.

Abstract: The present invention is directed to compounds of formula (I): wherein R1, R2 and R3 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl and X1 and X2 are independently a bond or an linker group of 1 to 6 atoms and may be optional substituted or oxidized, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof. The invention is also directed to methods of using the same for treating HIV infections, or AIDs or preventing viral replication.

Abstract: The present invention relates to carbamate derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

Abstract: The present invention is directed to compound of formula (A): wherein R1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl, or (b) CN and —C(NR10R11)?N—R12, R2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, R3-R12 are as described within the specification, and A is O, NR9 or S, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof, provided that R1 is not alkyl when R2 is pyridine, provided that at least one of R3-R8 is not H or F when A is O, R1 is (b) and R2 is a phenyl ring, a phenyl ring substituted at the para position with halo, —CN, —OCH3, —CF3 or —CO2CH3, a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety, provided that R4 is not methyl when R3 and R5-R8 are H, A is O, R1 is (b) and R2 is 4-chlorophenyl, and provided that R6 is not Cl when R3-R5 and R7-R8 are H, R1 is CN and R2 is phenyl.

Abstract: The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

Abstract: A magnetic shielding system for a fiber optic gyroscope is disclosed. The fiber optic gyroscope may have a sensing coil with a sensing axis. An exemplary magnetic shield may enclose the sensing coil and have a layer including a plurality of pieces connected at a seam. A portion of the seam may be substantially parallel to the sensing axis of the sensing coil. Also, the pieces may be connected together such that each piece has a portion of each of two sides and a wall of the magnetic shield. Additionally, multiple layers having orthogonal seams may be utilized with the magnetic shield.

Abstract: An adhesive system for use in minimizing the negative environmental influences on a fiber optic gyroscope comprises a free-standing substantially cylindrical sensing coil 12 having an inner coil surface, a rigid substantially cylindrical coil-supporting structure or hub 10 having a cylindrical wall and an outer surface, a plurality of grooves 16 formed into the hub's outer surface, a plurality of slots 24 formed into the outer surface of hub 10 and an adhesive 14 affixing hub 10 to coil 12. Adhesive 14 may be injected into manifolds 18 located in the cylindrical wall of hub 10, travel through the slots 24 into a gap existing between coil 12 and hub 10. Excess adhesive 14 may flow into grooves 16. Different orientations and sizes of grooves 16 and slots 24, different types and amounts of adhesive 14, and different thicknesses of adhesive between the coil 12 and hub 10 may be used to achieve suitable adhesion.