Abstract: The present invention relates to a culture media system that is useful for the isolation and epigenetically stable propagation of normal stem cells in culture, wherein the stem cells are derived from stratified epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.

Abstract: Disclosed herein are therapeutic conjugates having an extended circulating serum half-life. The therapeutic conjugates comprise a therapeutic moiety linked to a half-life extension moiety via a fibroblast activation protein, alpha (FAP?)-cleavable linker. Methods of using the therapeutic conjugates are also provided.

Abstract: Disclosed herein are therapeutic conjugates having an extended circulating serum half-life. The therapeutic conjugates comprise a drug moiety linked to a half-life extension moiety via an enzyme-cleavable linker. Methods of using the therapeutic conjugates are also provided.

Abstract: The present invention relates to a culture media system that useful for the isolation and epigenetically stable propagation of normal stem cells in culture which are derived from columnar epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.

Abstract: Provided herein, in some embodiments, are recombinantly engineered variant of stefin polypeptides (AFFIMER® polypeptides) that binds to human serum albumin and extends the half-life of the polypeptides. Also provided herein, in some embodiments, are composition containing the polypeptides, methods of using the polypeptides, and methods of producing the polypeptides.

Abstract: Provided herein, in some embodiments, are fusion proteins comprising recombinantly engineered variant of stefin polypeptide (an AFFIMER® polypeptide) that binds to PD-L1 and a polypeptide that binds to human serum albumin (HSA). Also provided herein, in some embodiments, are compositions containing the fusion proteins, methods of using the fusion proteins, and methods of producing the fusion proteins.

Abstract: The present invention relates to a culture media system that is useful for the isolation and epigenetically stable propagation of normal stem cells in culture which are derived from columnar epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.

Abstract: The present invention relates to a culture media system that is useful for the isolation and epigenetically stable propagation of normal stem cells in culture which are derived from columnar epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.

Abstract: Disclosed herein are methods and systems for establishing a network-based system for purchase and sale of at least one of an option contract and a futures contract to acquire a travel-related item. The contract may be exercisable upon occurrence of a contingency and tradable in an online marketplace. In some instances, the contract may be exercisable upon future existence of the travel-related item, occurrence of a weather condition, or the outcome of a contest, any of which may be uncertain at the time of the purchase and sale of the contract.

Abstract: A system for allowing a remote user to purchase and trade, over a distributed computer network (e.g., the Internet), an option for a ticket and/or accommodations for a “contingent event,” i.e., an event which is certain to occur but for which the participants, content and/or location(s) are not predetermined. For instance, the subject system can be used to sell and trade options for the purchase of tickets to such contingent events such as playoff games on the basis of what teams qualify.

Abstract: A system for allowing a remote user to purchase and trade, over a distributed computer network (e.g., the Internet), an option for a ticket and/or accommodations for a “contingent event,” i.e., an event which is certain to occur but for which the participants, content and/or location(s) are not predetermined. For instance, the subject system can be used to sell and trade options for the purchase of tickets to such contingent events such as playoff games on the basis of what teams qualify.

Abstract: A system for allowing a remote user to purchase, over a distributed computer network (e.g., the Internet), an option for a ticket and/or accommodations for a “contingent event,”i.e., an event which is certain to occur but for which the participants, content and/or location(s) are not predetermined. For instance, the subject system can be used to sell options for the purchase of tickets to contingent events such as playoff games on the basis of what individuals qualify for the game.

Abstract: Methods and systems of establishing a network-based system for purchase and sale of at least one of an option contract and a futures contract to acquire an item or to attend an event, wherein the contract is exercisable upon the occurrence of a contingency. The contingency may relate to the presence of a particular team in a game and the location of the game. In some instances, the contingency may relate to the position of a participant in the event in the standings at a time proximate to the occurrence of the event.

Abstract: Disclosed herein is a system for allowing a remote user to purchase, over a distributed computer network (e.g., the Internet), an option for a ticket and/or accommodations for a “contingent event”, e.g., an event which is certain to occur but for which the participants, content and/or location(s) are not predetermined. For instance, the subject system can be used to sell options for the purchase of tickets to such contingent events such as playoff games on the basis of what teams qualify, or all-star game.