Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: A computing system is configured to derive insights related to asset operation and present these insights via a GUI. To these ends, the computing system (a) receives data related to the operation of assets, (b) based on this data, derives a plurality of insights related to the operation of at least a subset of the assets, (c) from the insights, defines a given subset of insights to be presented to a user, (d) defines at least one aggregated insight representative of one or more individual insights in the given subset of insights that are related to a common underlying problem, and (e) causes the user's client station to display a visualization of the given subset of insights including (i) an insights pane that provides a high-level overview of the subset of insights and (ii) a details pane that provides additional details regarding a selected one of the subset of insights.

Abstract: A system and method for providing a communication session is provided. The system and method include a client device in communication with a plurality of communication networks. The system and method further includes a server also in communication with the plurality of communication networks. The client device includes a network monitor module and a dialer module. The network monitor module determines which networks to utilize in the communication session, and the dialer module initiates and terminates the communication session. The server receives a data signal associated with the communication session from the selected communication network. The server places a separate call to the recipient client device and completes the connection from the client device to the recipient client device by sending the data signal over the phone call to the recipient client device.

Abstract: A computing system is configured to derive insights related to asset operation and present these insights via a GUI. To these ends, the computing system (a) receives data related to the operation of assets, (b) based on this data, derives a plurality of insights related to the operation of at least a subset of the assets, (c) from the insights, defines a given subset of insights to be presented to a user, (d) defines at least one aggregated insight representative of one or more individual insights in the given subset of insights that are related to a common underlying problem, and (e) causes the user's client station to display a visualization of the given subset of insights including (i) an insights pane that provides a high-level overview of the subset of insights and (ii) a details pane that provides additional details regarding a selected one of the subset of insights.

Abstract: A computing system is configured to derive insights related to asset operation and present these insights via a GUI. To these ends, the computing system (a) receives data related to the operation of assets, (b) based on this data, derives a plurality of insights related to the operation of at least a subset of the assets, (c) from the insights, defines a given subset of insights to be presented to a user, (d) defines at least one aggregated insight representative of one or more individual insights in the given subset of insights that are related to a common underlying problem, and (e) causes the user's client station to display a visualization of the given subset of insights including (i) an insights pane that provides a high-level overview of the subset of insights and (ii) a details pane that provides additional details regarding a selected one of the subset of insights.

Abstract: A computing system is configured to derive insights related to asset operation and present these insights via a GUI. To these ends, the computing system (a) receives data related to the operation of assets, (b) based on this data, derives a plurality of insights related to the operation of at least a subset of the assets, (c) from the insights, defines a given subset of insights to be presented to a user, (d) defines at least one aggregated insight representative of one or more individual insights in the given subset of insights that are related to a common underlying problem, and (e) causes the user's client station to display a visualization of the given subset of insights including (i) an insights pane that provides a high-level overview of the subset of insights and (ii) a details pane that provides additional details regarding a selected one of the subset of insights.

Abstract: A system and method for providing a communication session is provided. The system and method include a client device in communication with a plurality of communication networks. The system and method further includes a server also in communication with the plurality of communication networks. The client device includes a network monitor module and a dialer module. The network monitor module determines which networks to utilize in the communication session, and the dialer module initiates and terminates the communication session. The server receives a data signal associated with the communication session from the selected communication network. The server places a separate call to the recipient client device and completes the connection from the client device to the recipient client device by sending the data signal over the phone call to the recipient client device.

Abstract: A system and method for providing a communication session is provided. The system and method include a client device in communication with a plurality of communication networks. The system and method further includes a server also in communication with the plurality of communication networks. The client device includes a network monitor module and a dialer module. The network monitor module determines which networks to utilize in the communication session, and the dialer module initiates and terminates the communication session. The server receives a data signal associated with the communication session from the selected communication network. The server places a separate call to the recipient client device and completes the connection from the client device to the recipient client device by sending the data signal over the phone call to the recipient client device.

Abstract: A system and method are provided for applying mechanical strain to a specimen of tissues and/or cells, for measuring the deformation of the specimen caused by the mechanical strain and for recording the deformation history for the specimen. The system comprises a specimen holder configured to hold a specimen and a strain-inducing apparatus coupled to the specimen holder and configured to apply a straining displacement of a preselected magnitude in at least a first preselected direction to the specimen to strain the specimen in a preselected manner. A measurement tool of the system measures the deformation of the specimen caused by the mechanical strain and a recording tool of the system records the deformation history for the specimen in memory.

Abstract: A system and method for providing a communication session is provided. The system and method include a client device in communication with a plurality of communication networks. The system and method further includes a server also in communication with the plurality of communication networks. The client device includes a network monitor module and a dialer module. The network monitor module determines which networks to utilize in the communication session, and the dialer module initiates and terminates the communication session. The server receives a data signal associated with the communication session from the selected communication network. The server places a separate call to the recipient client device and completes the connection from the client device to the recipient client device by sending the data signal over the phone call to the recipient client device.

Abstract: There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.

Abstract: A system and method for providing a communication session is provided. The system and method include a client device in communication with a plurality of communication networks. The system and method further includes a server also in communication with the plurality of communication networks. The client device includes a network monitor module and a dialer module. The network monitor module determines which networks to utilize in the communication session, and the dialer module initiates and terminates the communication session. The server receives a data signal associated with the communication session from the selected communication network. The server places a separate call to the recipient client device and completes the connection from the client device to the recipient client device by sending the data signal over the phone call to the recipient client device.

Abstract: There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.

Abstract: Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.

Abstract: Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.

Abstract: Systems and methods for cache coherency in multi-processor systems. A cache coherency system is used in a multi-processor computer system having a physical memory system in communication with the processors via a communication medium. A processor-side cache memory subsystem is associated with each processor of the multi-processor computer system. The cache coherency system includes a cache tag memory structure having a number of entries substantially equal to the defined number of entries for each processor-side cache memory. Each entry of the cache tag memory structure has at least one field corresponding to each processor-side cache memory subsystem.

Abstract: An on-die temperature control variable is provided to throttle a thermal actuator for cooling an integrated circuit. The integrated circuit includes a storage element to hold the temperature control variable. A temperature sensor is thermally coupled to the integrated circuit to sense an operating temperature of the integrated circuit. A thermal controller is communicatively coupled to the storage element and to the temperature sensor. The thermal controller throttles the thermal actuator when the temperature sensor indicates that the operating temperature of the integrated circuit is below the temperature control variable.