Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: A system and method are provided for investigating a remote host computer by using an agentless investigation system that includes a computer system with a computer processor coupled to a system memory and programmed with computer readable instructions. The method includes establishing a connection with the host computer and sending at least one agentless investigative module to the host computer. The investigative module runs on the host computer to perform at least one investigative function on the host computer. The investigative function includes an investigation of the host computer to ascertain if there are any user accounts of the host computer that have data forms including at least one authentication token in the form of an SSH public key. The investigative module is configured to locate the SSH public key and collect investigation data corresponding to the SSH public key.

Abstract: a blast nozzle is provided that has a conduit through it for accelerating air applied to the blast nozzle at pressure greater than ambient pressure. The air contains abrasive particles for abrading or “blasting” a workpiece. The conduit includes an inlet portion that converges from an inlet opening for receiving the air, to a throat for accelerating the air to a sonic speed. The conduit also includes an outlet portion that extends from the throat to a nozzle outlet for accelerating the air from the throat to a super-sonic speed at the nozzle outlet. A ratio of area of the nozzle outlet to area of the throat is selected for expansion of the air through the conduit so that air is emitted from the nozzle outlet in a jet at an ambient pressure. The jet imparts drag on the abrasive particles between the nozzle outlet and the workpiece which has been found to improve abrading of the workpiece by the abrasive particles.

Abstract: A nozzle arrangement for use in expelling pressurized fluid includes a dead man control. The dead man control has a manually operable control part movable between a non-operating position, which prevents operation of the nozzle arrangement, and an operating position, and biased towards the non-operating position. The manually operable control part is pivotably coupled relative to a nozzle holder of the nozzle arrangement, which extends away from the pivotal coupling substantially towards a distal end of a nozzle part of the nozzle arrangement. The manually operable control part includes a handle part which in the operating position is substantially against and aligned with the nozzle part.

Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.

Abstract: Epoxy compositions include a cucurbituril in complex with a curative, and methods for curing the epoxy composition. The curative is reactive with an epoxy compound, and the curative may be a cure accelerator or a cure hardener. Cured resins are obtained or obtainable from the epoxy compositions. Complexes of a cucurbituril have a curative.

Abstract: Epoxy compositions include a cucurbituril in complex with a curative, and methods for curing the epoxy composition. The curative is reactive with an epoxy compound, and the curative may be a cure accelerator or a cure hardener. Cured resins are obtained or obtainable from the epoxy compositions. Complexes of a cucurbituril have a curative.

Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.

Abstract: A hemostatic clip cartridge for holding a dispensing a polymeric hemostatic clip having a pair of legs connected at proximal ends to a hinge and latching means at distal ends of the legs, and including laterally projecting engagement means adapted to be slidingly received by notched jaws of an applier instrument. The cartridge includes a base having a plurality of longitudinally spaced clip retaining compartments for retaining individual clips carried at the hinge on a saddle extending between adjacent upwardly extending walls. A retainer secured to the base has laterally spaced deflectable arms projecting inwardly toward the saddle in resilient engagement with the legs of the clips. The deflectable arms have a U-shaped medial notch at the distal end having a base wall engagable with the legs and defining laterally spaced terminal fingers registering with said engagement means.

Abstract: A surgical clip removal instrument having operative surfaces at the distal jaws that directly compress the legs of a latched surgical clip and upon limited closure movement differentially elongate the clip legs to achieve an unlatched condition. Upon release of the jaws, the inherent resiliency of the clip outwardly biases the legs while maintaining contact with the jaws, allowing removal of the clip from the surgical site in a single piece.