Patents by Inventor Matthew Scharff

Matthew Scharff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to accelerate antibody diversification
    Patent number: 10308930
    Abstract: Methods for increasing somatic hypermutation of antibodies, especially in vitro expression of an isolated retroviral protein in an isolated mammalian immunoglobulin-producing cell, are provided.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: June 4, 2019
    Assignee: Albert Einstein College of Medicine
    Inventors: Xiaohua Wang, Matthew Scharff
  • METHODS TO ACCELERATE ANTIBODY DIVERSIFICATION
    Publication number: 20180179516
    Abstract: Methods for increasing somatic hypermutation of antibodies, especially in vitro expression of an isolated retroviral protein in an isolated mammalian immunoglobulin-producing cell, are provided.
    Type: Application
    Filed: November 5, 2015
    Publication date: June 28, 2018
    Inventors: Xiaohua WANG, Matthew SCHARFF
  • Peptides for the treatment and diagnosis of systemic lupus erythematosus
    Publication number: 20050214852
    Abstract: The present invention provides a method for identifying a peptide which binds to an anti-double stranded DNA antibody. The present invention also provides a class of peptides identified by the method of the present invention which bind to anti-double stranded DNA antibodies and compositions containing these peptides. The present invention also provides methods for the diagnosis and treatment of systemic lupus erythematosus utilizing the peptides of the present invention.
    Type: Application
    Filed: May 13, 2005
    Publication date: September 29, 2005
    Inventors: Bruce Gaynor, Betty Diamond, Matthew Scharff, Philippe Valadon
  • Mutations caused by activation-induced cytidine deaminase
    Publication number: 20050095712
    Abstract: Methods for causing mutations in genes expressed in eukaryotic cells are provided. The methods involve expressing an activation-induced cytidine deaminase (AID) in the cells. The mutated genes can be any gene that is operably linked to a promoter, where the gene is within about 2 kilobases of the promoter. Examples include antibody genes. Also provided are cells expressing AID. The cells can be from any eukaryote, and include hybridoma cells and myeloma fusion partners.
    Type: Application
    Filed: January 15, 2003
    Publication date: May 5, 2005
    Inventors: Alberto Martin, Matthew Scharff