Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: A system and a method are disclosed for disconnecting clips. A clip separation tool includes two arms, the arms having jaws to receive connected clips at a distal end of the arms and handle portions on a proximal end for a user to engage the tool with his hand. A pivot mechanism is coupled to the arms, where, responsive to a force applied to the handle portions, the arms rotate relative to each other around the pivot mechanism such that the distal ends of the arms pivot away from one another and the proximal ends of the arms pivot towards one another. A spring biases the arms to rotate to an equilibrium position that is attained automatically under spring loading once the proximal ends of the arms are relieved of loading. The clip separation tool disconnects connected clips as the force causes the arms to rotate around the pivot mechanism.

Abstract: Provided herein are methods for treatment of cystic fibrosis (CF), including for patients with class I CFTR mutations. The methods may involve administration of a recombinant adeno-associated virus (rAAV) that includes an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, or a pharmaceutical composition thereof.

Abstract: A computer system for executing a processing graph including: (A) accessing a graph definition of the processing graph from a nodes database, each node of the processing graph representing a component of computation performed by at least one program referenced by that node; (B) constructing the processing graph in the at least one memory device; (C) identifying at least one group of nodes in the processing graph; (D) traversing the at least one group of nodes; (E) upon visiting a node of the at least one group of nodes, accessing a node definition of the node from the nodes database, the node definition identifying a program referenced by the node; (F) executing the program to generate an output; and (G) passing the output to a parent node of the node, the parent node using the output during processing of the parent node.

Abstract: Photoactive compounds are disclosed. The disclosed photoactive compounds include metal complexes with dipyrromethene-based ligands, which can be substituted with a variety of different side chains or groups or can include various fused ring configurations, such as including aromatic or heteroaromatic groups. The metal complexes may include two dipyrromethene-based ligands, which can be the same or different. The photoactive compounds can be used as photoactive materials in organic photovoltaic devices, such as visibly transparent or opaque photovoltaic devices.

Abstract: A three-dimensional print head apparatus may include a securing mechanism, a hopper, a nozzle, a heating system, and a fume extraction system. The securing mechanism may be adapted to secure to a wrist joint of a robotic arm. The hopper may have a cavity and a lower aperture and may be secured to the securing mechanism. The nozzle may have an upper aperture and a lower aperture. The heating system may be positioned along the barrel.

Abstract: Provided herein is a method for sequence analysis that comprises analyzing PCR reactions that each contain different portions of the same sample, wherein at least some of the primer pairs are in more than one PCR reaction and at least one of the PCR reactions contains some but not all of the primer pairs of the other reaction(s).

Abstract: Methods and apparatus for identity and access management on networked machines are disclosed herein. An example non-transitory machine readable storage medium includes instructions to cause programmable circuitry to at least grant first permission to form a connection between a remote compute device and a local compute device based on a first identity of a first account, the connection to enable the first account to operate the local compute device by impersonating a second user, the second user associated with a second identity, access a request to execute a command on the remote compute device from the first account, and determine, based on the first identity of the first account and the second identity of the second user, whether second permission is to be granted to execute the command.

Abstract: A device for treating tissue includes a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the capsule releasably coupled to a proximal portion of the device and clip jaws, proximal ends of which are slidably received within the channel of the capsule so that the clip jaws are movable between an open configuration and a closed configuration. Clip jaws are configured so that a distance between the distal ends of the clip jaws in an open configuration is between 15 and 18 millimeters. Clip jaws further include barbs extending from a distal portion thereof.

Abstract: A method is provided that can include activating at least two wireless communication channels in parallel, between a first wireless transceiver and a second wireless transceiver. Each of the at least two wireless communication channels can operate at a different radio carrier frequency, and the first wireless transceiver may be part of a first vehicle. The method can also include transmitting, by the first wireless transceiver, common information in parallel on the at least two wireless communication channels to the second wireless transceiver and deactivating the at least two wireless communication channels.

Abstract: Systems and methods are described for generating efficient iterative electronic recommendation structures. In various aspects, one or more processors aggregate a plurality of ratings vectors, where each ratings vector is associated with a vector type and contains one or more content ranking metrics associated with one or more users. The one or more processors generate similarity pairing values from the plurality of ratings vectors, where each similarity pairing value is based on a similarity mapping between a first ratings vector and a second ratings vector. The one or more processors further generate an electronic recommendation structure based on the similarity pairing values, where the electronic recommendation structure includes a bi-directional look-up interface that is configured to return a bi-directional recommendation value after receiving a lookup request for either the vector type of the first ratings vector or the vector type of the second ratings vector.

Abstract: A programmable motion system is disclosed that includes a dynamic end effector system. The dynamic end effector system includes an end effector that is coupled via a dynamic coupling to the programmable motion system, wherein the dynamic coupling provides that at least a portion of the end effector may spin with respect to an other portion of the end effector.

Abstract: An object processing system within a trailer for a tracker trailer is discloses. The object processing system includes an input area of the trailer at which objects to be processed may be presented, a perception system for providing perception data regarding objects to be processed, and a primary transport system for providing transport of each object in one of at least two primary transport directions within the trailer based on the perception data.

Abstract: A system is disclosed for providing high flow vacuum control to an end effector of an articulated arm. The system includes a high flow vacuum source that provides an opening with an area of high flow vacuum at the end effector such that objects may be engaged while permitting substantial flow of air through the opening, and a load detection system for characterizing the load presented by the object.

Abstract: Apparatuses, such as semiconductor device packages, may include, for example, a device substrate including a semiconductor material and bond pads coupled with an active surface of the device substrate. A package substrate may be secured to the device substrate, the package substrate configured to route signals to and from the bond pads. A ball grid array may be supported on, and electrically connected to, the package substrate. Each ball of the ball grid array positioned and configured to carry a clock signal or a strobe signal may be located in a central column of the ball grid array.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The container is mounted in a cradle that tips downward in arcuate motion for discharge or proppant through a top opening The tipping mechanism may be driven by a system of gears or a hydraulic ram.

Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins is in communication with a retrieval conveyance system, a programmable motion device in communication with the retrieval conveyance system for receiving the storage bins from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and a movable carriage for receiving the selected object from the end effector of the programmable motion device, and for carrying the selected object to one of a plurality of destination bins.

Abstract: A nanofiber comprising a polyamide including at least one substituted phenyl group is provided. The nanofiber includes an average diameter from about 50 to about 1000 nm. A fibrous mat including a plurality of the nanofibers is also provided. A composite including a plurality of the nanofibers and a continuous matrix resin is also provided. A method of forming the nanofibers is also provided.

Abstract: A firearm mount, components thereof, and associated methods. The firearm can be configured for use with an AR-15 style firearm or other type of firearm. The firearm mount is adapted to securely hold the firearm assembly in position for cleaning, maintenance, and/or gunsmithing tasks. The firearm mount can include a lock configured to selectively lock and unlock a firearm assembly thereon.