Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as activators from AMPK, pharmaceutical compositions containing such compounds and their use to treat, for example, heart failure or peripheral vascular disease.

Abstract: A liquid personal cleansing composition comprising: (a) from about 1% to about 15% by weight of short chain alkyl sulphate surfactant having an average of from 8 to 10 carbon atoms in the alkyl chain and mixtures thereof; (b) from about 1% to about 60% by weight of water-soluble auxiliary surfactant selected from anionic surfactant other than C.sub.8 to C.sub.10 alkyl sulphate, nonionic, zwitterionic and amphoteric surfactants and mixtures thereof; (c) from about 0.01% to about 5% by weight of cationic polymeric skin conditioning agent; and (d) water. The products demonstrate excellent in-use efficacy benefits including mildness, a moisturised skin feel, excellent rinsibility and good product stability and lather attributes.

Abstract: A liquid personal cleansing composition comprising: (a) from about 5% to about 60% by weight of water-soluble surfactant selected from anionic, nonionic and amphoteric surfactants and mixtures thereof; and (b) from about 0.01% to about 10% by weight of a hydrophobically modified nonionic cellulose ether selected from C.sub.14 -C.sub.18 alkyl and alkenyl modified, hydroxyethyl cellulose ethers having a degree of nonionic substitution in the range of from about 2.2 to about 2.8 and a degree of hydrophobic substitution in the range of from about 0.4% to about 0.6% by weight; and (c) water, and wherein the composition displays a shear stress of about 150 Pa at a shear rate in the range from about 400 s.sup.-1 to about 600 s.sup.-1 at 25.degree. C. The products demonstrate excellent in-use efficacy benefits including mildness, a moisturised skin feel, good rinsibility and good product stability.

Abstract: A liquid personal cleansing composition comprising: a) from about 5% to about 60% by weight of water-soluble surfactant selected from anionic, nonionic and amphoteric surfactants and mixtures thereof; b) from about 0.01% to about 10% by weight of a hydrophobically modified nonionic cellulose ether selected from C.sub.10 -C.sub.24 alkyl and alkenyl modified methyl, hydroxyethyl and hydroxypropyl cellulose ethers having a degree of nonionic substitution in the range of from about 1.8 to about 4 and a degree of hydrophobic substitution in the range of from about 0.1% to about 1% by weight; c) from about 0% to about 10% by weight of a water-soluble polyol; d) from about 0.01% to about 5% by weight of cationic polymeric skin conditioning agent; and e) water, and wherein the composition displays a shear stress of about 150 Pa at a shear rate in the range from about 100 s.sup.-1 to about 600 s.sup.-1 at 25.degree. C.