Abstract: A three-dimensional print head apparatus may include a securing mechanism, a hopper, a nozzle, a heating system, and a fume extraction system. The securing mechanism may be adapted to secure to a wrist joint of a robotic arm. The hopper may have a cavity and a lower aperture and may be secured to the securing mechanism. The nozzle may have an upper aperture and a lower aperture. The heating system may be positioned along the barrel.

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

Abstract: The present invention relates to a preparative chromatography system (200, 500, 800) and a chromatography process (400, 700) adapted to repetitive cycling of chromatography volumes. The system (200, 500, 800) comprises at least two upstream pumps (203a, 803a, 203b, 803b) and separate flow paths (220) from process liquid sources to the chromatography device (200, 500, 800). The system (200, 500, 800) is arranged to prime one flow path (220) with one process liquid while providing another process liquid to the chromatography device and thereby minimizing the hold-up volume of the system (200, 500, 800).

Abstract: A system and method are provided for measuring the performance of a synthetic peer-managed content distribution network. Each node peers with one or more other nodes to share the content and facilitate its presentation to associated users. Each node collects session metadata for identifying the node's environment, presentation events regarding presentation of the content to users, and transfer events regarding the sharing of the content among peers. The nodes report their data toward a central entity that feeds the different types of data through different ETL pipelines to obtain the performance measurements. For example, the session metadata may allow the reach of a content item to be determined, the presentation events may be used to determine the quality of experience with the content item for users, and the transfer events may be used to determine how much external bandwidth the network conserved and/or how efficiently the nodes shared the content.

Abstract: The present invention relates to a method for monitoring operational status in a column capture chromatography system configured for cyclical repetitive purification performed on a volume of sample feed comprising at least one product configured to be captured in the column during loading. The method comprises: performing (51) a purification cycle; measuring (52) at least one parameter during the purification cycle indicative of breakthrough of the at least one captured product after the column during loading of sample feed; when breakthrough is detected, reducing (56a) the amount of sample feed loaded during loading in the next purification cycle; and repeating the steps to perform another purification cycle. Each purification cycle comprising: loading an amount of sample feed onto the column, washing the column and eluting the at least one product.

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

Abstract: A system and method are provided for measuring the performance of a synthetic peer-managed content distribution network. Each node peers with one or more other nodes to share the content and facilitate its presentation to associated users. Each node collects session metadata for identifying the node's environment, presentation events regarding presentation of the content to users, and transfer events regarding the sharing of the content among peers. The nodes report their data toward a central entity that feeds the different types of data through different ETL pipelines to obtain the performance measurements. For example, the session metadata may allow the reach of a content item to be determined, the presentation events may be used to determine the quality of experience with the content item for users, and the transfer events may be used to determine how much external bandwidth the network conserved and/or how efficiently the nodes shared the content.

Abstract: A synthetic peer-managed content delivery network self-organizes for the purpose of accessing one content item or a limited number of content items. A node joins the network at an identified attachment zone by requesting connections with existing nodes associated with the zone. Connected nodes become peers. The node may attempt to achieve a maximum number of peer connections, including upstream peers one hop closer to a root node, midstream peers the same distance from the root node, and downstream nodes one hop further from the root node. The content item is shared (in pieces or components if necessary) from a given peer to its midstream and downstream peers. Each node regularly informs its peers of its status regarding the content item and, to help organize the network, indicates whether its connected peers are able to accept a new peer connection.

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

Abstract: A chromatography system comprising at least two chromatography units (3) connected in parallel, wherein said at least two chromatography units (3) each comprises a convection-based chromatography material, wherein an initial difference in back pressure provided from the different chromatography units (3) is compensated dynamically during run of the system due to a change of chromatography unit properties provided during the chromatography process.

Abstract: The present invention relates to a method for purifying a feed comprising at least one target product in a chromatography system having a plurality of purifying units, each having an inlet and an outlet, and a valve assembly having an outlet port and an inlet port. The inlet and the outlet of each purifying unit being connected to a respective port of the valve assembly. The method comprising loading (S10) the plurality of purifying units with feed provided through the inlet port of the valve assembly by sequentially connecting each purifying unit to the inlet port of the valve assembly: eluting (S12) the plurality of purifying units using an elution provided through the inlet port of the valve assembly by sequentially connecting each purifying unit to the inlet port of the valve assembly: and collecting (S14) the at least one target product from the outlet port of the valve.

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

Abstract: The Fly Down Decoy consists of a game bird decoy with a free-floating wheel inside of it. A rope is attached to a pole at a vertical position, then extended horizontally from the pole where it is attached to the ground. This rope runs from the pole through the game bird decoy, running under the wheel inside of the decoy, and to ground level. The wheel inside, allows the decoy to travel freely along the rope from an elevated position to ground level, imitating a game bird flying and landing. Cord, which is secured to the decoy, runs to a retriever and then to the operator. This allows the operator to release the decoy when he/she chooses. The cord also provides the operator the ability to retrieve the decoy back up the rope to be released as often as the operator chooses.

Abstract: A punch for forming a punched opening in a metal sheet having an elongated body with a first and second spaced apart ends. The first end is adapted to be held by a machine which, when activated, axially drives the body. The second end of the body includes an annular surface corresponding in shape and size to the punched opening as well as an extension which protrudes outwardly from and is surrounded by the annular surface. The extension has a length greater than the thickness of the sheet metal so that, as the punch is driven through the sheet metal, the extension forms a hole in the sheet metal smaller than the opening and thereafter the annular surface forms the opening of the desired size in the metal sheet.