Abstract: Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.

Abstract: The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Abstract: The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Abstract: A dock for a surgical equipment holder is disclosed. The dock for a surgical equipment holder includes a base having a central arm mount and a lower clamping jaw. The dock for a surgical equipment holder also includes an upper clamp jaw movably coupled to the base. The dock for a surgical equipment holder also includes a central docking arm coupled to the central arm mount and a central ball cup coupled to the to the central docking arm. The dock for a surgical equipment holder also includes a central attachment nut coupled to the central ball cup. The central attachment nut may include an extendable moment arm, and the dock may also include a ball coupled between the central ball cup and the central attachment nut and a surgical equipment holder attached to the ball.

Abstract: The present disclosure relates to methods of treating or preventing cancer (e.g., advanced solid cancer) using Compound No. 1 or Compound No. 2: or a pharmaceutically acceptable salt thereof. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

Abstract: A sternal elevator apparatus is disclosed. The sternal elevator may include a panel, a support beam traversing the panel, and a post coupled to a proximal end of the panel. The apparatus may also include an indicator handle coupled to the sternal elevator, an actuator drive pivotably coupled to the indicator handle, and a housing movably coupled to the actuator drive. The sternal elevator apparatus may have an actuator drive incorporating a linear rack. The housing further may include a cylindrical gear where the cylindrical gear is engaged with the linear rack.

Abstract: A sternal elevator apparatus is disclosed. The sternal elevator may include a panel, a support beam traversing the panel, and a post coupled to a proximal end of the panel. The apparatus may also include an indicator handle coupled to the sternal elevator, an actuator drive pivotably coupled to the indicator handle, and a housing movably coupled to the actuator drive. The sternal elevator apparatus may have an actuator drive incorporating a linear rack. The housing further may include a cylindrical gear where the cylindrical gear is engaged with the linear rack.

Abstract: A sternal elevator apparatus is disclosed. The sternal elevator may include a panel, a support beam traversing the panel, and a post coupled to a proximal end of the panel. The apparatus may also include an indicator handle coupled to the sternal elevator, an actuator drive pivotably coupled to the indicator handle, and a housing movably coupled to the actuator drive. The sternal elevator apparatus may have an actuator drive incorporating a linear rack. The housing further may include a cylindrical gear where the cylindrical gear is engaged with the linear rack.

Abstract: A device for vessel harvesting is disclosed. The device for vessel harvesting includes a distal housing, a dissector coupled to the distal housing, a drive element coupled to the dissector, and an actuator coupled to the drive element. The device for vessel harvesting may also include a rotatable dissector, a shaft coupled to the distal housing having a first articulation joint movable within a first plane, and a second articulation joint movable within a second plane, which is substantially perpendicular to the first plane, a barrel chain drive element coupled to the rotatable dissector, and an actuator coupled to the drive element. The device for vessel harvesting may also include a member slidably engaged to the distal tip.

Abstract: A sternal elevator apparatus is disclosed. The sternal elevator may include a panel, a support beam traversing the panel, and a post coupled to a proximal end of the panel. The apparatus may also include an indicator handle coupled to the sternal elevator, an actuator drive pivotably coupled to the indicator handle, and a housing movably coupled to the actuator drive. The sternal elevator apparatus may have an actuator drive incorporating a linear rack. The housing further may include a cylindrical gear where the cylindrical gear is engaged with the linear rack.

Abstract: A suturing device for minimally invasive surgery is disclosed. The suturing device has a head defining one or more ferrule holders and a tissue bite area. The device also has a first needle comprising a flywheel portion and one or more curved arms extending from the flywheel portion, each of the one or more curved arms comprising a ferrule engaging tip, wherein the first needle is pivotably coupled to the head. The suturing device further has a first actuator coupled to the first needle and configured to rotate it from a retracted position, where the ferrule engaging tip of each of the one or more curved arms starts away from the one or more ferrule holders, through the tissue bite area, and to an engaged position where the ferrule engaging tip of each of the one or more curved arms is operationally aligned with the one or more ferrule holders.

Abstract: A suturing device for minimally invasive surgery is disclosed. The suturing device has a head defining one or more ferrule holders and a tissue bite area. The device also has a first needle comprising a flywheel portion and one or more curved arms extending from the flywheel portion, each of the one or more curved arms comprising a ferrule engaging tip, wherein the first needle is pivotably coupled to the head. The suturing device further has a first actuator coupled to the first needle and configured to rotate it from a retracted position, where the ferrule engaging tip of each of the one or more curved arms starts away from the one or more ferrule holders, through the tissue bite area, and to an engaged position where the ferrule engaging tip of each of the one or more curved arms is operationally aligned with the one or more ferrule holders.

Abstract: A sternal elevator apparatus is disclosed. The sternal elevator may include a panel, a support beam traversing the panel, and a post coupled to a proximal end of the panel. The apparatus may also include an indicator handle coupled to the sternal elevator, an actuator drive pivotably coupled to the indicator handle, and a housing movably coupled to the actuator drive. The sternal elevator apparatus may have an actuator drive incorporating a linear rack. The housing further may include a cylindrical gear where the cylindrical gear is engaged with the linear rack.

Abstract: A dock for a surgical equipment holder is disclosed. The dock for a surgical equipment holder includes a base having a central arm mount and a lower clamping jaw. The dock for a surgical equipment holder also includes an upper clamp jaw movably coupled to the base. The dock for a surgical equipment holder also includes a central docking arm coupled to the central arm mount and a central ball cup coupled to the to the central docking arm. The dock for a surgical equipment holder also includes a central attachment nut coupled to the central ball cup. The central attachment nut may include an extendable moment arm, and the dock may also include a ball coupled between the central ball cup and the central attachment nut and a surgical equipment holder attached to the ball.

Abstract: A rotary motor and a method of making the same include a vibrating motor body which has two orthogonal first bending modes and is substantially enclosed within a housing. A shaft is frictionally coupled to the vibrating motor body and is arranged to rotate in at least one direction about a rotation axis in response to the vibrating motor body. The shaft is frictionally coupled the vibrating motor body by a force substantially perpendicular to the rotation axis. One or more bearings support the shaft, are connected to the housing, and define the axis of rotation of the shaft.

Abstract: A rotary motor and a method of making the same include a vibrating motor body which has two orthogonal first bending modes and is substantially enclosed within a housing. A shaft is frictionally coupled to the vibrating motor body and is arranged to rotate in at least one direction about a rotation axis in response to the vibrating motor body. The shaft is frictionally coupled the vibrating motor body by a force substantially perpendicular to the rotation axis. One or more bearings support the shaft, are connected to the housing, and define the axis of rotation of the shaft.

Abstract: The differential steering drive for a tracked vehicle includes a drive differential interconnecting the drive shafts for the tracks and a steering differential for superimposing additive and subtractive rotations to the tracks for steering and pivot turning. In the preferred embodiment for high speed tracked vehicles, the drive differential is an all-gear no-clutch type limited-slip differential, and the steering differential is an unlimited-slip differential. The differentials are arranged to provide no-slip track operation traveling in straight paths or when steering so long as at least one track has traction. In another embodiment for pivot-turning slow-moving off-road vehicles, both the drive differential and the steering differential are all-gear no-clutch type limited-slip differentials.

Abstract: The transmission includes an orbital gear complex in combination with a variable hydraulic pump and motor. The input to the transmission is increased in speed by the orbital gearing such that, when the pump and motor are not operating, the orbiter is stationary, and the orbital gearing produces an overdrive condition. A gear reduction is accomplished by rotating the web with the web-rotating device, providing a high gear reduction. The pump and motor are preferably long-piston hydraulic machines with infinitely variable swash plates. The hydraulic machines preferably have wobblers stabilized by full gimbals and hold-down plates with elongated holes for the long pistons to eliminate possible impacts between the hold-down plates and the head ends of the long pistons when the swash-plates are at or near their maximum angle of inclination.

Abstract: Smaller and lighter hydraulic pump/motors provide remarkably improved volumetric efficiency with pistons having body portions substantially as long as the axial length of the respective cylinders in which they reciprocate. A plurality of respective lubricating channels form a single, continuous lubricating passageway entirely within the cylinder block and not connected by either fluid “input” or fluid “output” passageways, being replenished solely by a minimal flow of fluid to and from the valve end of each cylinder and passing between each respective cylindrical wall of each cylinder and the axial cylindrical body of each respective piston. Several embodiments are disclosed in combination with various spring-biased hold-down assemblies. The preferred embodiment includes a fixed cylinder block, a roller bearing mounting between the wobbler and rotor of a split-swash plate, with piston shoes contacting the wobbler directly without any intermediary apparatus.

Abstract: The modular transmission uses only a pair of small and light hydraulic machines of remarkably improved volumetric efficiency with pistons having body portions substantially as long as the axial length of the respective cylinders in which they reciprocate. The two hydraulic machines operate in a closed loop, one being used as a pump driven by the vehicle's engine, and the other used as a motor. Each machine has a fully articulatable swash plate. By computer control, the angles of the swash plates of the two machines are infinitely varied to provide an appropriate optimum ratio of engine/wheel speed for all conditions from start-up, city driving, hill climbing varied according to load and steepness, and over-drive for highway. This complete vehicle operation is attained while the vehicle's engine continues to operate at relatively constant speeds and relatively low RPM.