Abstract: The invention relates to an automatic focusing apparatus for the microscopic examination of a plurality of spatially distributed (biological) samples, whereby an object stage that is vertically movable relative to the microscope has a carriage that is translatable along the x-axis and y-axis and a sample stage that is translatable along the z-axis and is mounted on the carriage. Furthermore, the invention relates to a method for automatic focusing and microscopic examination of a plurality of spatially distributed biological samples, through a microscope having an object stage that is vertically movable relative to the microscope.

Abstract: A computer implemented method for controlling a synthesis process for a chemical or biological product, comprising the steps of at a processing device of a synthesis specification control module receiving via a communication interface a synthesis specification for the synthesis process, deriving a set of experimental requirements from the synthesis specification, receiving via the communication interface device laboratory equipment data associated with at least one laboratory equipment device deriving a set of equipment properties from the laboratory equipment data associated with at least one laboratory equipment device, comparing the set of experimental requirements with the set of equipment properties, generating control data based on the comparison providing with the processing device the control data suitable for controlling the synthesis process.

Abstract: The invention relates to esterquats which can be obtained by reacting di- or trialkanolamines with a mixture of fatty acids and polycarboxylic acids, and the esters obtained in this manner are then quaternized with an alkylating agent, wherein the di- or trialkanolamines correspond to formula (I), in which R1 and R2 independently of one another represent hydroxyalkyl groups with 1 to 20 carbon atoms, hydroxyalkenyl groups with 2 to 20 carbon atoms and 1, 2, or 3 double bonds, or addition products of 1 to 20 mol ethylene oxide on a hydroxyethyl group and R3 represents hydrogen, an alkyl group with 1 to 20 carbon atoms, an alkenyl group with 2 to 20 carbon atoms and 1, 2, or 3 double bonds, a hydroxyalkyl group with 1 to 20 carbon atoms, a hydroxyalkenyl group with 2 to 20 carbon atoms and 1, 2, or 3 double bonds, or addition products of 1 to 20 mol ethylene oxide on a hydroxyethyl group; the fatty acids correspond to formula (II), R4—COOH??(II) in which R4 represents an aliphatic, linear, or branched hyd

Abstract: The invention relates to a polyester comprising two or more of the structural units (a1), one or more of the structural units (a2) and either one or two of the terminal groups (a3) wherein G1 is one or more of (OCnH2n) with n being a number of from 2 to 10, preferably from 2 to 6 and more preferably (OC2H4), (OC3H6), (OC4H8) or (OC6H12), R1 is a C1-30 alkyl, preferably C1-4 alkyl and more preferably methyl, p is, based on a molar average, a number of at least 60, preferably from 70 to 200 and more preferably from 90 to 130, q is, based on a molar average, a number of from 0 to 40, preferably from 0 to 30, more preferably from 0 to 20, and most preferably from 0 to 10, where the (OC3H6)— and (OC2H4)-groups of the terminal group (a3) may be arranged blockwise, alternating, periodically and/or statistically, preferably blockwise and/or statistically, either of the groups (O—C3H6)— and (O—C2—H4)— of the terminal group (a3) can be linked to R1— and O—, adjacent structural units (a1) are connected by the

Abstract: The invention relates to an automatic focusing apparatus for the microscopic examination of a plurality of spatially distributed (biological) samples, whereby an object stage that is vertically movable relative to the microscope has a carriage that is translatable along the x-axis and y-axis and a sample stage that is translatable along the z-axis and is mounted on the carriage. Furthermore, the invention relates to a method for automatic focusing and microscopic examination of a plurality of spatially distributed biological samples, through a microscope having an object stage that is vertically movable relative to the microscope.

Abstract: The present disclosure relates to a washing- and cleaning-active polymer film which includes a mixture of at least one polymer P1) including polymerized units of at least one ?,?-ethylenically unsaturated carboxylic acid or a salt thereof. The washing- and cleaning-active polymer film optionally further includes comonomers and a polyoxyalkylene ether PE). The disclosure furthermore relates to a process for producing such a washing- and cleaning-active polymer film and to a covering or coating for a detergent or cleaner portion which includes such a polymer film.

Abstract: The invention relates to esterquats which can be obtained by reacting di- or trialkanolamines with a mixture of fatty acids and polycarboxylic acids, and the esters obtained in this manner are then quaternized with an alkylating agent, wherein the di- or trialkanolamines correspond to formula (I), in which R1 and R2 independently of one another represent hydroxyalkyl groups with 1 to 20 carbon atoms, hydroxyalkenyl groups with 2 to 20 carbon atoms and 1, 2, or 3 double bonds, or addition products of 1 to 20 mol ethylene oxide on a hydroxyethyl group and R3 represents hydrogen, an alkyl group with 1 to 20 carbon atoms, an alkenyl group with 2 to 20 carbon atoms and 1, 2, or 3 double bonds, a hydroxyalkyl group with 1 to 20 carbon atoms, a hydroxyalkenyl group with 2 to 20 carbon atoms and 1, 2, or 3 double bonds, or addition products of 1 to 20 mol ethylene oxide on a hydroxyethyl group; the fatty acids correspond to formula (II), R4—COOH (II) in which R4 represents an aliphatic, linear, or branched hyd

Abstract: This invention generally relates to methods for the treatment of IL-23 related diseases, in particular inflammatory diseases, such as psoriasis, psoriatic arthritis or axial (spinal) spondyloarthritis (ax-SpA), including ankylosing spondylitis and non-radiographic ax-SpA, utilizing anti-IL-23A antibodies.

Abstract: The invention provides a new method for the preparation of the dimeric Pd(l) tri-tert.-butylphosphine bromide complex, characterized by the chemical formula [Pd(?-Br)(PtBu3)]2. The method is based on a comproportionation reaction in which a Pd(ll) compound (?PdBr2) is reacted with a Pd(0) compound (?Pd(PtBu3)2) in organic solvents to yield the [Pd(?-Br)(PtBu3)]2 compound having the Pd atoms in the formal oxidation state +1. Unreacted PdBr2 may be reused in the process. The method is straightforward and applicable for industrial scale production and provides high product yields. Further, a new process for the isomerization of allyl ethers of the general type R1—C(O)—O—CH(R2)—C(R3)?CH2 employing the compound Pd?-Br)(PtBu3)]2 as a catalyst is disclosed.

Abstract: The invention provides a new method for the preparation of the dimeric Pd(l) tri-tert.-butylphosphine bromide complex, characterized by the chemical formula [Pd(?-Br)(PtBu3)]2. The method is based on a comproportionation reaction in which a Pd(ll) compound (=PdBr2) is reacted with a Pd(0) compound (=Pd(PtBu3)2) in organic solvents to yield the [Pd(?-Br)(PtBu3)]2 compound having the Pd atoms in the formal oxidation state +1. Unreacted PdBr2 may be reused in the process. The method is straightforward and applicable for industrial scale production and provides high product yields. Further, a new process for the isomerization of allyl ethers of the general type R1—C(O)—O—CH(R2)—C(R3)?CH2 employing the compound Pd?-Br)(PtBu3)]2 as a catalyst is disclosed.

Abstract: The invention relates to a method for producing acetylenedicarboxylic acid by reaction of acetylene with carbon dioxide, wherein the reaction is carried out in the presence of a silver or copper salt and an amine base.

Abstract: A reaction unit containing a bottom part and a top part for pipetting a liquid, wherein the bottom part contains a reaction cavity with a permeable filter grid insert and the top part contains a reaction cavity which can be fixed on said bottom part and contains a cavity or covering for receiving a magnet.

Abstract: A reaction unit containing a bottom part and a top part for pipetting a liquid, wherein the bottom part contains a reaction cavity with a permeable filter grid insert and the top part contains a reaction cavity which can be fixed on said bottom part and contains a cavity or covering for receiving a magnet.