Patents by Inventor Matthias Schnabelrauch
Matthias Schnabelrauch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11045578Abstract: The invention provides a three dimensional (3D), porous, biodegradable and biocompatible tissue engineering scaffold, wherein at least 25% w/w of the scaffold is particulate egg shell membrane (ESM) distributed substantially uniformly therein and the scaffold is essentially dry. Methods for preparing the same by freeze-drying and cryogelation and the use thereof in methods of tissue engineering and to promote the healing of wounds are also provided.Type: GrantFiled: June 24, 2016Date of Patent: June 29, 2021Assignee: BIOVOTEC ASInventors: Enda Kenny, Ralf Schmidt, Henri-Pierre Suso, Matthias Schnabelrauch, Annika Wartenberg
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Patent number: 10980887Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: GrantFiled: February 23, 2018Date of Patent: April 20, 2021Assignee: ETH ZURICHInventors: Marcy Zenobi-Wong, Gemma Palazzolo, Rami Mhanna, Jana Becher, Stefanie Moller, Matthias Schnabelrauch
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Publication number: 20190185416Abstract: It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1: For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.Type: ApplicationFiled: August 11, 2017Publication date: June 20, 2019Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Ralf WYRWA, Claudia RODE, Thomas SEEMANN, Lorenz MEINEL, Jennifer RITZER, Matthias SCHNABELRAUCH
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Publication number: 20180177882Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: ApplicationFiled: February 23, 2018Publication date: June 28, 2018Applicant: ETH ZurichInventors: Marcy ZENOBI-WONG, Gemma PALAZZOLO, Rami MHANNA, Anne BECHER, Stefanie MOLLER, Matthias SCHNABELRAUCH
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Patent number: 9937257Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: GrantFiled: November 4, 2013Date of Patent: April 10, 2018Assignee: ETH ZurichInventors: Marcy Zenobi-Wong, Gemma Palazzolo, Rami Mhanna, Jana Becher, Stefanie Moller, Matthias Schnabelrauch
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Patent number: 9669111Abstract: The document proposes a diagnostic chewing gum for identifying the presence of inflammatory tissues in the mouth, in particular in or adjacent to the mandible, the maxilla, an implant or the teeth of a user, comprising a base material or particles (3) embedded and/or attached to the base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user; wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4), e.g. a proteolytic enzyme, which is released by inflammatory tissue in response to bacterial mediators.Type: GrantFiled: March 7, 2013Date of Patent: June 6, 2017Assignee: THOMMEN MEDICAL AGInventors: Matthias Schnabelrauch, Lorenz Meinel, Falko Schlottig, Ralf Wyrwa
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Patent number: 9526803Abstract: Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles (3) embedded and/or attached to the base material and an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.Type: GrantFiled: March 8, 2013Date of Patent: December 27, 2016Assignee: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz Meinel, Matthias Schnabelrauch, Falko Schlottig
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Publication number: 20150290327Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: ApplicationFiled: November 4, 2013Publication date: October 15, 2015Applicant: ETH ZURICHInventors: Marcy Zenobi-Wong, Gemma Palazzolo, Rami Mhanna, Jana Becher, Stefanie Moller, Matthias Schnabelrauch, Ece Oeztuerk, Oystein Arlov
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Patent number: 9050391Abstract: The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.Type: GrantFiled: October 17, 2006Date of Patent: June 9, 2015Assignee: NEXILIS AGInventors: Falko Schlottig, Matthias Schnabelrauch, Armin Rex Kautz
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Patent number: 8940320Abstract: The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.Type: GrantFiled: October 17, 2006Date of Patent: January 27, 2015Assignee: Thommen Medical AGInventors: Falko Schlottig, Matthias Schnabelrauch, Armin Rex Kautz
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Publication number: 20150023879Abstract: The document proposes a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, comprising a base material or particles (3) embedded and/or attached to said base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to said base material and/or said particles, for the generation of a change in the chewing gum directly detectable by the user; wherein said pathogen is selected from the group consisting of virus, bacterium, protozoa, prion, fungus or a combination thereof; and wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by said pathogens, or, in case of a virus or prion, by the cellular structure hosting it.Type: ApplicationFiled: March 8, 2013Publication date: January 22, 2015Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz Meinel, Matthias Schnabelrauch, Falko Schlottig
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Publication number: 20150017101Abstract: The document proposes a diagnostic chewing gum for identifying the presence of inflammatory tissues in the mouth, in particular in or adjacent to the mandible, the maxilla, an implant or the teeth of a user, comprising a base material or particles (3) embedded and/or attached to said base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to said base material and/or said particles, for the generation of a change in the chewing gum directly detectable by the user; wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4), e.g. a proteolytic enzyme, which is released by inflammatory tissue in response to bacterial mediators.Type: ApplicationFiled: March 7, 2013Publication date: January 15, 2015Applicant: THOMMEN MEDICAL AGInventors: Matthias Schnabelrauch, Lorenz Meinel, Falko Schlottig, Ralf Wyrwa
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Patent number: 8642064Abstract: A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture.Type: GrantFiled: November 25, 2004Date of Patent: February 4, 2014Assignee: Curasan AGInventors: Matthias Schnabelrauch, Sebastian Vogt, Ute (Erbe) Reif
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Patent number: 8414958Abstract: What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.Type: GrantFiled: February 23, 2009Date of Patent: April 9, 2013Assignee: Thommen Medical AGInventors: Matthias Schnabelrauch, Armin Rex Kautz, Falko Schlottig
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Patent number: 8092824Abstract: An antibiotic coating of implants is described, which is characterized in that the coating comprises at least one saturated, organic, hydrophobic, low molecular matrix former whose melting point is in the temperature range of 45° C. to 100° C., in which a low molecular, hydrophobic additive is dissolved and that an antibiotic/antibiotics is/are suspended in the mixture of matrix former and additive and/or in which an antibiotic/antibiotics miscible with a mixture of matrix former and additive is/are dissolved.Type: GrantFiled: January 19, 2006Date of Patent: January 10, 2012Assignee: Heraeus Kulzer GmbHInventors: Klaus-Dieter Kühn, Sebastian Vogt, Matthias Schnabelrauch
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Publication number: 20110053113Abstract: What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.Type: ApplicationFiled: February 23, 2009Publication date: March 3, 2011Applicant: Thommen Medical AGInventors: Matthias Schnabelrauch, Armin Rex Kautz, Falko Schlottig
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Publication number: 20100262182Abstract: Described are occlusion instruments (1, 2, 3, 4) comprising bioresorbable and thermoplastically deformable polymers with or without shape memory characteristics, which contain radiopaque building groups in the repeat units of the polymer chains and/or are modified with bioresorbable, radiopaque nanoparticles. The polymers display sufficient strength and deformability, good bioresorbability and sufficient visibility in radiance and are particularly useful for producing metal-free occlusion instruments for closing defects of the septum in the heart, the positioning of which being monitorable using routine diagnostic methods.Type: ApplicationFiled: May 15, 2008Publication date: October 14, 2010Inventors: Robert Moszner, Kathrin Schmidt, Norbert Moszner, Claudia Rode, Thomas Pautsch, Ralf-Peter Gottlöber, Matthias Schnabelrauch
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Publication number: 20090130177Abstract: The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.Type: ApplicationFiled: October 17, 2006Publication date: May 21, 2009Applicant: THOMMEN MEDICAL AGInventors: Falko Schlottig, Matthias Schnabelrauch, Armin Rex Kautz
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Publication number: 20080286328Abstract: The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.Type: ApplicationFiled: October 17, 2006Publication date: November 20, 2008Applicant: NEXILIS AGInventors: Falko Schlottig, Matthias Schnabelrauch, Armin Rex Kautz
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Patent number: 7358232Abstract: The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage.Type: GrantFiled: June 19, 2002Date of Patent: April 15, 2008Assignee: Heraeus Kulzer GmbH & Co.KGInventors: Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kühn