Patents by Inventor Matthias Wenzel
Matthias Wenzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240161892Abstract: The present invention relates to optimizing a health state of a patient. An apparatus comprises a) means for receiving a patient-specific value of at least one parameter; b) means for generating a profile for the patient based at least in part on the patient-specific value; c) means for selecting a stored profile out of one or more stored profiles of the patient and/or of other patients in a storage medium, the selecting based on a comparison of the stored profile and the generated profile for the patient, wherein the stored profile comprises a stored feedback and a stored patient-specific value of the at least one parameter; and d) means for providing feedback to patient based on the stored feedback.Type: ApplicationFiled: February 22, 2022Publication date: May 16, 2024Applicant: BIOTRONIK SE & Co. KGInventors: Matthias WENZEL, Miro SELENT, Georg NOLLERT, Dominic WIST
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Publication number: 20240136069Abstract: The present invention relates to determining a deterioration of a health state of a patient. A system comprises: a) means for receiving a first acoustic input, associated with the health state of the patient at a first time, and a second acoustic input, associated with the health state of the patient at a second time; b) means for determining whether the health state of the patient has deteriorated based at least in part on a comparison of the first acoustic input with the second acoustic input; c) means for indicating the deterioration of the health state of the patient, if it is determined that the health state of the patient has deteriorated.Type: ApplicationFiled: February 22, 2022Publication date: April 25, 2024Applicant: BIOTRONIK SE & Co. KGInventor: Matthias WENZEL
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Publication number: 20230159484Abstract: The invention relates to novel, water-soluble fluorescent dyes with high fluorescence quantum yield based on oxygen-containing heterocycles, their reactive derivatives and dye conjugates, and their use for labelling samples and detecting analytes. The compounds of the new dye class are compatible with commercial excitation light sources and are characterised by Stokes shifts of more than 50 nm.Type: ApplicationFiled: April 1, 2021Publication date: May 25, 2023Inventors: Bernd SCHWEDER, Frank LEHMANN, Matthias WENZEL, Peter CZERNEY
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Patent number: 9393400Abstract: The present disclosure relates to a coupling, in particular a hub (2 a-i), with a base body (23 a-i) having a proximal end (24 a-i), embodied as a connecting region (25 a-i) for an applicator (26 a-i), and a distal end (27 a-i), embodied as connecting region (28 a-i) for a delivery device (29 a-i) with a tubular member (30 a-i) for delivering a medical device (31 a-1) into a part of an animal or human body, and having a recess (9 a-i) extending between the proximal end (24 a-i) and the distal end (27 a-i). It is provided that the recess (9 a-i) is positioned eccentrically from an outer diameter (20 a-i) of the base body (23 a-i) and a central axis (18 a-i) of the recess (9 a-i) is nonparallel in respect to a central axis (32 a-i) of the outer diameter (20 a-i) of the base body (23 a-i).Type: GrantFiled: January 27, 2011Date of Patent: July 19, 2016Assignee: BIOTRONIK SE & CO KGInventors: Christian S. Eversull, Stephen A. Leeflang, Matthias Wenzel
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Patent number: 9308365Abstract: A detachable electrode and anchor utilized with electrode leads and leadless medical implants that enable explantation of the electrode while leaving the anchor in place. The detachable electrode and anchor utilizes a detachable mechanism that detachably couples the electrode to the anchor. Embodiments do not require removal of existing scar tissue before explantation, which minimize chances of internal bleeding at the extraction site. Embodiments also minimize impact on the vein in which the electrode lead travels by eliminating use of a necessarily larger diameter sheath that is utilized around the electrode lead to remove the electrode lead and attached anchor.Type: GrantFiled: September 25, 2013Date of Patent: April 12, 2016Assignee: BIOTRONIK SE & CO. KGInventors: Karl Nordstrom, Michael J. Ayton, Matthias Wenzel
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Patent number: 9238145Abstract: A leadless implantable device delivery apparatus that enables testing of an implantation site before permanent implantation and enables secure attachment at the site while minimizing effects of the implantation procedure. Embodiments include a delivery sheath configured to accommodate a leadless implantable device, the leadless implantable device having an anchor that includes at least one projection configured to physically attach the anchor to tissue, such as heart tissue. In addition, embodiments include an adapter that resides within the delivery sheath and is configured to impart rotational force at the distal end of the adapter that is applied to the proximal end of the adapter to rotate the anchor associated with the implantable device.Type: GrantFiled: September 24, 2013Date of Patent: January 19, 2016Assignee: BIOTRONIK SE & Co. KGInventors: Matthias Wenzel, Michael J. Ayton, Karl Nordstrom
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Publication number: 20140148675Abstract: A detachable electrode and anchor utilized with electrode leads and leadless medical implants that enable explantation of the electrode while leaving the anchor in place. The detachable electrode and anchor utilizes a detachable mechanism that detachably couples the electrode to the anchor. Embodiments do not require removal of existing scar tissue before explantation, which minimize chances of internal bleeding at the extraction site. Embodiments also minimize impact on the vein in which the electrode lead travels by eliminating use of a necessarily larger diameter sheath that is utilized around the electrode lead to remove the electrode lead and attached anchor.Type: ApplicationFiled: September 25, 2013Publication date: May 29, 2014Applicant: Biotronik SE & Co. KGInventors: Karl Nordstrom, Michael J. Ayton, Matthias Wenzel
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Publication number: 20140148815Abstract: A leadless implantable device delivery apparatus that enables testing of an implantation site before permanent implantation and enables secure attachment at the site while minimizing effects of the implantation procedure. Embodiments include a delivery sheath configured to accommodate a leadless implantable device, the leadless implantable device having an anchor that includes at least one projection configured to physically attach the anchor to tissue, such as heart tissue. In addition, embodiments include an adapter that resides within the delivery sheath and is configured to impart rotational force at the distal end of the adapter that is applied to the proximal end of the adapter to rotate the anchor associated with the implantable device.Type: ApplicationFiled: September 24, 2013Publication date: May 29, 2014Applicant: BIOTRONIK SE & Co. KGInventors: Matthias Wenzel, Michael J. Ayton, Karl Nordstrom
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Patent number: 8634968Abstract: The invention relates to a communication system for a motor vehicle for transmitting an information relating to the operation of the motor vehicle from a transmitting control device to a receiving control device. The communication system comprises an interface for the input or output of the information relating to the operation of the motor vehicle. Communication can be established via the interface by means of a protocol which comprises an operation field for identifying a task to be carried out using the information relating to the operation of the motor vehicle.Type: GrantFiled: March 11, 2005Date of Patent: January 21, 2014Assignees: Audi AG, Volkswagen AGInventors: Frank-Martin Wille, Holger Esser, Heinz-Willi Vassen, Tobias Ammler, Norbert Ammler, Helmut Lebmeier, Yvonne Gross, Hans-Christian Jung, Rudolf Leinfelder, Jens Kötz, Carsten Krömke, Stefan Anderlik, Christian Penshorn, Matthias Wenzel
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Patent number: 8515617Abstract: A control system for a motor vehicle comprises an output control unit for outputting data related to the operation of the motor vehicle and an operation control unit spatially separated from the output control unit for generating or providing data related to the operation of the motor vehicle. The output control unit comprises a data storage for storing data related to the operation of the motor vehicle and the data related to the operation of the motor vehicle can be read out of the data storage and outputted by the output control unit.Type: GrantFiled: March 11, 2005Date of Patent: August 20, 2013Assignees: Audi AG, Volkswagen AGInventors: Frank-Martin Wille, Holger Esser, Heinz-Willi Vassen, Tobias Ammler, Norbert Ammler, Helmut Lebmeier, Yvonne Grob, Hans-Christian Jung, Rudolf Leinfelder, Jens Kötz, Carsten Krömke, Stefan Anderlik, Christian Penshorn, Matthias Wenzel
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Patent number: 8378115Abstract: Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR.Type: GrantFiled: September 30, 2008Date of Patent: February 19, 2013Assignee: Thermo Fisher Scientific (Milwaukee) LLCInventors: Charles K. Brush, Jianqin Liu, Peter Czerney, Matthias Wenzel
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Publication number: 20110270268Abstract: The present disclosure relates to a coupling, in particular a hub (2 a-i), with a base body (23 a-i) having a proximal end (24 a-i), embodied as a connecting region (25 a-i) for an applicator (26 a-i), and a distal end (27 a-i), embodied as connecting region (28 a-i) for a delivery device (29 a-i) with a tubular member (30 a-i) for delivering a medical device (31 a-1) into a part of an animal or human body, and having a recess (9 a-i) extending between the proximal end (24 a-i) and the distal end (27 a-i). It is provided that the recess (9 a-i) is positioned eccentrically from an outer diameter (20 a-i) of the base body (23 a-i) and a central axis (18 a-i) of the recess (9 a-i) is nonparallel in respect to a central axis (32 a-i) of the outer diameter (20 a-i) of the base body (23 a-i).Type: ApplicationFiled: January 27, 2011Publication date: November 3, 2011Inventors: Christian S. Eversull, Stephen A. Leeflang, Matthias Wenzel
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Patent number: 7951959Abstract: Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labeling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diastereomeric cyanines with high hydrophilicity and other desirable properties.Type: GrantFiled: September 16, 2009Date of Patent: May 31, 2011Assignee: Thermo Fisher Scientific (Milwaukee) LLCInventors: Charles K. Brush, Kaizhang He, Peter T. Czerney, Matthias Wenzel
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Publication number: 20100285470Abstract: Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR.Type: ApplicationFiled: September 30, 2008Publication date: November 11, 2010Applicant: Thermo Fisher Scientific (Milwaukee) LLCInventors: Charles K. Brush, Jianqin Liu, Peter Czerney, Matthias Wenzel
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Publication number: 20100069258Abstract: Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labeling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diastereomeric cyanines with high hydrophilicity and other desirable properties.Type: ApplicationFiled: September 16, 2009Publication date: March 18, 2010Applicant: Thermo Fisher Scientific (Milwaukee) LLCInventors: Charles K. Brush, Kaizhang He, Peter T. Czemey, Matthias Wenzel
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Patent number: 7563907Abstract: The invention relates to fluorescent dyes (fluorophores) based on polymethines for use in optical measurement and detection procedures, in particular those employing fluorescence, for example in medicine, in pharmacology and in the biological, materials and environmental sciences. The objective was to create fluorophores based on polymethines that have a large Stokes shift, high photostability, long storage life and a high fluorescent quantum yield, and that can be excited in the simplest possible manner by white-light sources or laser radiation in the UV, visible or NIR spectral region. According to the invention dyes on the basis of polymethines having the general formulas I, II or III are employed.Type: GrantFiled: May 14, 2004Date of Patent: July 21, 2009Assignee: Dyomics GmBHInventors: Peter Czerney, Matthias Wenzel, Bernd Schweder, Frank Lehmann
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Patent number: 7351829Abstract: The invention relates to compounds based on merocyanines with the general formulas I and/or II, where n=0 or an integer from 1 to 3, X=O or S and the residues R1 to R12 are the same or different and signify in particular hydrogen or various organic residues, without or with functional groups, and R2 incorporates an amine function. The compounds in accordance with the invention are suitable as fluorescent dyes (fluorophores) for used in optical determination and demonstration methods, in particular those employing fluorescence, for example in medicine, pharmacology and the biological, materials and environmental sciences. They are characterized by high photostability and long storage life, and exhibit a high fluorescence quantum yield. Excitation causing them to emit light can be achieved in a simple manner, by white-light sources or by laser irradiation in the UV, visible or NIR spectral region.Type: GrantFiled: July 3, 2002Date of Patent: April 1, 2008Assignee: Dyomics GmbHInventors: Peter Czerney, Wilhelm Frank, Matthias Wenzel, Frank Lehmann
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Publication number: 20070208469Abstract: The invention relates to a communication system for a motor vehicle for transmitting an information relating to the operation of the motor vehicle from a transmitting control device to a receiving control device. The communication system comprises an interface for the input or output of the information relating to the operation of the motor vehicle. Communication can be established via the interface by means of a protocol which comprises an operation field for identifying a task to be carried out using the information relating to the operation of the motor vehicle.Type: ApplicationFiled: March 11, 2005Publication date: September 6, 2007Applicants: AUDU AG, VOLKSWAGENWEK AGInventors: Frank-Martin Wille, Holger Esser, Heinz-Willi Vassen, Tobias Ammler, Norbert Ammler, Helmut Lebmeier, Yvonne Gross, Hans-Christian Jung, Rudolf Leinfelder, Jens Kotz, Carsten Kromke, Stefan Anderlik, Christian Penshorn, Matthias Wenzel
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Publication number: 20070198137Abstract: A control system for a motor vehicle comprises an output control unit for outputting data related to the operation of the motor vehicle and an operation control unit spatially separated from the output control unit for generating or providing data related to the operation of the motor vehicle. The output control unit comprises a data storage for storing data related to the operation of the motor vehicle and the data related to the operation of the motor vehicle can be read out of the data storage and outputted by the output control unit.Type: ApplicationFiled: March 11, 2005Publication date: August 23, 2007Applicants: AUDU AG, VOLKSWAGENWERK AGInventors: Frank-Martin Wille, Holger Esser, Heinz-Willi Vassen, Tobias Ammler, Norbert Ammler, Helmut Lebmeier, Yvonne Gross, Hans-Christian Jung, Rudoff Leinfelder, Jens Kotz, Carsten Kromke, Stefan Anderlik, Christian Penshorn, Matthias Wenzel
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Publication number: 20070128659Abstract: Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydrophilicity and other desirable properties.Type: ApplicationFiled: December 5, 2006Publication date: June 7, 2007Applicant: DYOMICS GMBHInventors: Peter Czerney, Wilhelm Frank, Frank Lehmann, Bernd Schweder, Matthias Wenzel