Patents by Inventor Mattias Tidare
Mattias Tidare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9174214Abstract: The present invention relates to a method of coupling multiple binding agents to respective areas of a substrate surface by hydrodynamic addressing, using two laminar fluid flows that flow together in the same direction over the substrate surface with an interface to each other to successively couple the binding agents to the substrate areas, wherein each successive coupling of a binding agent to a surface area is followed or preceded by selective deactivation or activation of a selected surface area according to a defined protocol. The invention also relates to the use of such a binding agent-coupled substrate surface for analytical purposes.Type: GrantFiled: October 8, 2009Date of Patent: November 3, 2015Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Pär Säfsten, Mattias Tidare
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Patent number: 8021626Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: April 26, 2010Date of Patent: September 20, 2011Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Publication number: 20100260642Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: April 26, 2010Publication date: October 14, 2010Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg
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Patent number: 7811515Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: June 30, 2009Date of Patent: October 12, 2010Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Patent number: 7736587Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: June 30, 2009Date of Patent: June 15, 2010Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Publication number: 20100029015Abstract: The present invention relates to a method of coupling multiple binding agents to respective areas of a substrate surface by hydrodynamic addressing, using two laminar fluid flows that flow together in the same direction over the substrate surface with an interface to each other to successively couple the binding agents to the substrate areas, wherein each successive coupling of a binding agent to a surface area is followed or preceded by selective deactivation or activation of a selected surface area according to a defined protocol. The invention also relates to the use of such a binding agent-coupled substrate surface for analytical purposes.Type: ApplicationFiled: October 8, 2009Publication date: February 4, 2010Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: PÄR SÄFSTEN, Mattias Tidare
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Publication number: 20090263285Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: June 30, 2009Publication date: October 22, 2009Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Publication number: 20090263284Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: June 30, 2009Publication date: October 22, 2009Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: MAGNUS MALMQVIST, Hakan Roos, Stefen Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Patent number: 7582487Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: December 6, 2005Date of Patent: September 1, 2009Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg
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Patent number: 7219528Abstract: A method of positioning a laminar flow of a sample fluid on a surface within a flow cell is disclosed. The method comprises providing a laminar flow of a first guiding fluid adjacent to a laminar flow of a second guiding fluid different from the first guiding fluid such that the two fluids flow together over the surface with a detectable interface to each other; detecting the interface between the two different guiding fluids; optionally adjusting the interface laterally to a desired position by adjusting the relative flow rates of the two guiding fluids; and introducing a laminar flow of the sample fluid between the laminar flows of the first and second guiding fluids such that the flow of the sample fluid is sandwiched between the guiding fluids. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.Type: GrantFiled: December 6, 2004Date of Patent: May 22, 2007Assignee: Biacore ABInventors: Mattias Tidare, Roos Håkan
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Patent number: 7105356Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: January 12, 2001Date of Patent: September 12, 2006Assignee: Biacore ABInventors: Magnus Malmqvist, H{dot over (a)}kan Roos, Stefan Sjölander, Mattias Tidare, H{dot over (a)}kan Sjödin, Ralph St{dot over (a)}lberg
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Publication number: 20060134800Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: December 6, 2005Publication date: June 22, 2006Applicant: Biacore ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Patent number: 7015043Abstract: A method of operating an analytical flow cell device comprising an elongate flow cell having a first end and a second end, at least two ports at the first end and at least one port at the second end, comprises introducing a laminar flow of a first fluid at the first end of the flow cell, and a laminar counter flow of a second fluid at the second end. Each fluid flow is discharged at the first end or the second end, and the position of the interface between the first and second fluids in the longitudinal direction of the flow cell is adjusted by controlling the relative flow rates of the first and second fluids. Also disclosed are a method of analyzing a fluid sample for an analyte, a method of sensitizing a sensing surface, and a method of contacting a sensing surface with a test fluid.Type: GrantFiled: June 26, 2002Date of Patent: March 21, 2006Assignee: Biacore ABInventors: Håkan Roos, Kjell Magnusson, Mattias Tidare
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Publication number: 20050199076Abstract: A method of positioning a laminar flow of a sample fluid on a surface within a flow cell is disclosed. The method comprises providing a laminar flow of a first guiding fluid adjacent to a laminar flow of a second guiding fluid different from the first guiding fluid such that the two fluids flow together over the surface with a detectable interface to each other; detecting the interface between the two different guiding fluids; optionally adjusting the interface laterally to a desired position by adjusting the relative flow rates of the two guiding fluids; and introducing a laminar flow of the sample fluid between the laminar flows of the first and second guiding fluids such that the flow of the sample fluid is sandwiched between the guiding fluids. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.Type: ApplicationFiled: December 6, 2004Publication date: September 15, 2005Applicant: Biacore ABInventors: Mattias Tidare, Hakan Roos
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Publication number: 20040058456Abstract: The present invention relates to a method of coupling multiple binding agents to respective areas of a substrate surface by hydrodynamic addressing, using two laminar fluid flows that flow together in the same direction over the substrate surface with an interface to each other to successively couple the binding agents to the substrate areas, wherein each successive coupling of a binding agent to a surface area is followed or preceded by selective deactivation or activation of a selected surface area according to a defined protocol. The invention also relates to the use of such a binding agent-coupled substrate surface for analytical purposes.Type: ApplicationFiled: May 30, 2003Publication date: March 25, 2004Applicant: Biacore ABInventors: Par Safsten, Mattias Tidare
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Publication number: 20030022388Abstract: A method of operating an analytical flow cell device comprising an elongate flow cell having a first end and a second end, at least two ports at the first end and at least one port at the second end, comprises introducing a laminar flow of a first fluid at the first end of the flow cell, and a laminar counter flow of a second fluid at the second end. Each fluid flow is discharged at the first end or the second end, and the position of the interface between the first and second fluids in the longitudinal direction of the flow cell is adjusted by controlling the relative flow rates of the first and second fluids. Also disclosed are a method of analyzing a fluid sample for an analyte, a method of sensitizing a sensing surface, and a method of contacting a sensing surface with a test fluid.Type: ApplicationFiled: June 26, 2002Publication date: January 30, 2003Applicant: Biacore ABInventors: Hakan Roos, Kjell Magnusson, Mattias Tidare
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Publication number: 20010055817Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: January 12, 2001Publication date: December 27, 2001Inventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Patent number: 6200814Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: January 20, 1998Date of Patent: March 13, 2001Assignee: Biacore ABInventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg