Abstract: The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.

Abstract: An intelligent power supply system includes a transformer and at least one gate unit. The transformer is configured to electrically connect to a higher voltage power source and to convert the higher voltage to a first reduced voltage. The transformer provides the first reduced voltage via a first output. The gate unit is operable to receive the first output and provide a second output at a second reduced voltage. At least one low voltage electrical device is electrically connectable to the second output. The transformer may electrically connect to a higher voltage power source at a first location, with the gate unit disposed at a second location remote from the first location, whereby the higher voltage power source is not at or near the second location, which may comprise a display location with various electrically powered display devices that are powered by the reduced voltage provided by the gate unit.

Abstract: Improvements to the physical layer are provided, for example a test circuit that does not introduce further skew into critical clock signals. A boundary scan test circuit is also provided used to isolate an integrated circuit for applying test vectors or circuit brand connections to test the integrity thereof. A bias voltage generator for a voltage controlled delay line (VCDL) is also provided.

Abstract: Improvements to the physical layer are provided, for example a test circuit that does not introduce further skew into critical clock signals. A boundary scan test circuit is also provided used to isolate an integrated circuit for applying test vectors or circuit brand connections to test the integrity thereof. A bias voltage generator for a voltage controlled delay line (VCDL) is also provided.

Abstract: Improvements to the physical layer are provided, for example a test circuit that does not introduce further skew into critical clock signals. A boundary scan test circuit is also provided used to isolate an integrated circuit for applying test vectors or circuit brand connections to test the integrity thereof. A bias voltage generator for a voltage controlled delay line (VCDL) is also provided.

Abstract: Improvements to the physical layer are provided, for example a test circuit that does not introduce further skew into critical clock signals. A boundary scan test circuit is also provided used to isolate an integrated circuit for applying test vectors or circuit brand connections to test the integrity thereof. A bias voltage generator for a voltage controlled delay line (VCDL) is also provided.

Abstract: A precision spindle unit for low friction performance includes a tubular housing surrounding a shaft, and first and second rolling bearings mounted on the shaft within the housing. The first bearing is axially arrested between the flange of a locking washer fixed to the shaft and a shoulder on the shaft. A second locking washer is fitted to the shaft, and a resilient member is provided between the second locking washer and a side of the inner race ring of the second bearing. The axially inwardly facing side of the outer race ring of the second bearing engages an inwardly projecting shoulder in the housing, with the second bearing being biased between the resilient member and the inwardly projecting shoulder. The locking washers define a slot seal at each axial end of the housing to provide a seal at the outwardly facing sides of the first and second bearings.

Abstract: A fishing reel includes a spool rotatably supported in a bearing arrangement on a spindle unit. The spindle unit is a held-together unit incorporating an elongated spindle and a bearing housing supported on the spindle by at least two spaced apart rolling bearings. Annular end washers on the spindle shield off the interior of the housing from the surrounding environment via a small slot acting as a seal. The housing has at least one exterior radially extending shoulder and the spool has at least one internal projection intended to engage the shoulder of the housing to define the axial position of the spool relative to the bearings while also taking up axial load in one direction. A resilient member between the bearing housing and the spool gives play-free contact between the housing and the spool and gives a pretension of the spindle unit against the shoulder of the housing.

Abstract: A fishing reel includes a spool rotatably supported in a bearing arrangement on a spindle unit. The spindle unit is a held-together unit incorporating an elongated spindle and a bearing housing supported on the spindle by at least two spaced apart rolling bearings. Annular end washers on the spindle shield off the interior of the housing from the surrounding environment via a small slot acting as a seal. The housing has at least one exterior radially extending shoulder and the spool has at least one internal projection intended to engage the shoulder of the housing to define the axial position of the spool relative to the bearings while also taking up axial load in one direction. A resilient member between the bearing housing and the spool gives play-free contact between the housing and the spool and gives a pretension of the spindle unit against the shoulder of the housing.

Abstract: A precision spindle unit for low friction performance includes a tubular housing surrounding a shaft, and first and second rolling bearings mounted on the shaft within the housing. The first bearing is axially arrested between the flange of a locking washer fixed to the shaft and a shoulder on the shaft. A second locking washer is fitted to the shaft, and a resilient member is provided between the second locking washer and a side of the inner race ring of the second bearing. The axially inwardly facing side of the outer race ring of the second bearing engages an inwardly projecting shoulder in the housing, with the second bearing being biased between the resilient member and the inwardly projecting shoulder. The locking washers define a slot seal at each axial end of the housing to provide a seal at the outwardly facing sides of the first and second bearings.

Abstract: A circuit board holder and module including the circuit board and holder are described wherein a cover plate integral with the holder is in thermal contact with the heat producing elements mounted on the circuit board. The heat generated in the elements is transferred through the cover plate to the peripheral portions of the holder where the holder is in contact with a heat sink.