Patents by Inventor Maurizio Pacifici
Maurizio Pacifici has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240033401Abstract: The present invention provides an injectable scaffold comprising a plurality of unclad microfibers, and a diluent solution.Type: ApplicationFiled: December 17, 2021Publication date: February 1, 2024Inventors: Li-Hsin Han, Mingkun Wang, Chunxiao Cui, John Todd Lawrence, Maurizio Pacifici
-
Publication number: 20230201146Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: ApplicationFiled: August 4, 2022Publication date: June 29, 2023Inventors: Masahiro IWAMOTO, Maurizio PACIFICI
-
Patent number: 11433039Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: GrantFiled: April 9, 2019Date of Patent: September 6, 2022Assignee: Thomas Jefferson UniversityInventors: Masahiro Iwamoto, Maurizio Pacifici
-
Publication number: 20200069620Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: ApplicationFiled: April 9, 2019Publication date: March 5, 2020Inventors: Masahiro IWAMOTO, Maurizio PACIFICI
-
Patent number: 10292954Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: GrantFiled: August 10, 2017Date of Patent: May 21, 2019Assignee: Thomas Jefferson UniversityInventors: Masahiro Iwamoto, Maurizio Pacifici
-
Publication number: 20180110799Abstract: Compositions and methods for inhibiting chondrogenesis are disclosed.Type: ApplicationFiled: September 2, 2015Publication date: April 26, 2018Inventors: Maurizio Pacifici, Julianne Huegel
-
Publication number: 20180000762Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: ApplicationFiled: August 10, 2017Publication date: January 4, 2018Inventors: Masahiro IWAMOTO, Maurizio Pacifici
-
Patent number: 9789074Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: GrantFiled: August 31, 2011Date of Patent: October 17, 2017Assignee: Thomas Jefferson UniversityInventors: Masahiro Iwamoto, Maurizio Pacifici
-
Patent number: 9314439Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: GrantFiled: June 18, 2014Date of Patent: April 19, 2016Assignee: Thomas Jefferson UniversityInventors: Masahiro Iwamoto, Maurizio Pacifici
-
Publication number: 20140363402Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: ApplicationFiled: August 31, 2011Publication date: December 11, 2014Applicant: THOMAS JEFFERSON UNIVERSITYInventors: Masahiro Iwamoto, Maurizio Pacifici
-
Publication number: 20140303223Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.Type: ApplicationFiled: June 18, 2014Publication date: October 9, 2014Inventors: Masahiro IWAMOTO, Maurizio PACIFICI
-
Patent number: 8318658Abstract: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.Type: GrantFiled: January 14, 2009Date of Patent: November 27, 2012Assignee: University of PennsylvaniaInventors: Masahiro Iwamoto, Yoshinobu Higuchi, Maurizio Pacifici, Joel Rosenbloom
-
Publication number: 20090275030Abstract: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.Type: ApplicationFiled: January 14, 2009Publication date: November 5, 2009Inventors: Masahiro IWAMOTO, Yoshinobu Higuchi, Maurizio Pacifici, Joel Rosenbloom
-
Patent number: 7494970Abstract: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.Type: GrantFiled: May 24, 2004Date of Patent: February 24, 2009Assignee: The University of PennsylvaniaInventors: Masahiro Iwamoto, Yoshinobu Higuchi, Maurizio Pacifici, Joel Rosenbloom
-
Publication number: 20040254113Abstract: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.Type: ApplicationFiled: May 24, 2004Publication date: December 16, 2004Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Masahiro Iwamoto, Yoshinobu Higuchi, Maurizio Pacifici, Joel Rosenbloom
-
Publication number: 20030114482Abstract: The present invention relates to methods for treating cartilage and bone pathologies, including bone growth related diseases such as osteoarthritis or osteoporosis, comprising administering therapeutically effective amounts of retinoid receptor antagonists or retinoid receptor agonists.Type: ApplicationFiled: April 20, 2000Publication date: June 19, 2003Inventors: Maurizio Pacifici, Roshantha A. Chandraratna
-
Publication number: 20020164739Abstract: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.Type: ApplicationFiled: July 12, 2001Publication date: November 7, 2002Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Masahiro Iwamoto, Yoshinobu Higuchi, Maurizio Pacifici, Joel Rosenbloom
-
Patent number: 6313168Abstract: The present invention relates to methods for treating cartilage and bone pathologies, including bone growth related diseases such as osteoarthritis, comprising administering therapeutically effective amounts of retinoid receptor antagonists.Type: GrantFiled: December 15, 1999Date of Patent: November 6, 2001Assignee: Allergan Sales, Inc.Inventors: Maurizio Pacifici, Roshantha A. Chandraratna
-
Patent number: 6294354Abstract: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.Type: GrantFiled: June 18, 1997Date of Patent: September 25, 2001Inventors: Masahiro Iwamoto, Yoshinobu Higuchi, Maurizio Pacifici, Joel Rosenbloom