Abstract: The present disclosure relates to processes for suspending stretched nucleic acids over surface features. These processes can be used to prepare stretched nucleic acids that are more active in enzymatic reactions and other reactions than those laid down on a flat surface. These processes can be achieved by using a photoresist layer on top of a substrate, stretch a nucleic acid on top of the surface, and then remove part of the photoresist to form surface features that suspend the stretched nucleic acid. Furthermore, the formation of a hydrogel layer over the stretched nucleic acid and the surface features can transfer the stretched nucleic acid to the hydrogel for further reactions, including enzymatic reactions.

Abstract: The present disclosure relates to processes for suspending stretched nucleic acids over surface features. These processes can be used to prepare stretched nucleic acids that are more active in enzymatic reactions and other reactions than those laid down on a flat surface. These processes can be achieved by using a photoresist layer on top of a substrate, stretch a nucleic acid on top of the surface, and then remove part of the photoresist to form surface features that suspend the stretched nucleic acid. Furthermore, the formation of a hydrogel layer over the stretched nucleic acid and the surface features can transfer the stretched nucleic acid to the hydrogel for further reactions, including enzymatic reactions.

Abstract: The present disclosure relates to processes for suspending stretched nucleic acids over surface features. These processes can be used to prepare stretched nucleic acids that are more active in enzymatic reactions and other reactions than those laid down on a flat surface. These processes can be achieved by using a photoresist layer on top of a substrate, stretch a nucleic acid on top of the surface, and then remove part of the photoresist to form surface features that suspend the stretched nucleic acid. Furthermore, the formation of a hydrogel layer over the stretched nucleic acid and the surface features can transfer the stretched nucleic acid to the hydrogel for further reactions, including enzymatic reactions.

Abstract: Method and system of optical manipulation of micrometer-sized objects, which comprises the steps of placing a pattern (2) of a certain material on a surface (1), wherein said material is capable of sustaining surface plasmons; placing a solution (4) comprising micrometer-sized objects in contact with said surface (1) and said pattern (2); applying at least one optical beam (5) at a certain wavelength and with a certain incident angle (?) to said surface (1) for certain time interval, thereby creating surface plasmons forces at said surface (1), in such a way that said micrometer-sized objects are trapped by the pattern (2) in a stable and selective way. Optical trap and use thereof as a tool for optically driven lab-on-a-chip.

Abstract: Method and system of optical manipulation of micrometer-sized objects, which comprises the steps of placing a pattern (2) of a certain material on a surface (1), wherein said material is capable of sustaining surface plasmons; placing a solution (4) comprising micrometer-sized objects in contact with said surface (1) and said pattern (2); applying at least one optical beam (5) at a certain wavelength and with a certain incident angle (?) to said surface (1) for certain time interval, thereby creating surface plasmons forces at said surface (1), in such a way that said micrometer-sized objects are trapped by the pattern (2) in a stable and selective way. Optical trap and use thereof as a tool for optically driven lab-on-a-chip.