Abstract: The present invention relates to a combination of a CXCL8 activity inhibitor and a corticosteroid, and a pharmaceutical composition thereof, for use in the treatment of corticosteroid-insensitive asthma as well as to a method for treating corticosteroid-insensitive asthma by administration of said pharmaceutical composition.

Abstract: Severe influenza is associated with defects in pulmonary innate immunity, a phenomenon leading to secondary bacterial infections. The gut microbiota can control immune/inflammatory responses locally and at distant sites. The inventors hypothesized that perturbation of the gut microbiota during severe influenza might participate in bacterial superinfection post-influenza. Their data demonstrated that influenza infection profoundly altered the functionality of the gut microbiota as assessed by the altered production of short chain fatty acids (SCFAs). Remarkably, treatment of colonized (IAV microbiota) mice or IAV-infected mice with acetate, the main SCFA found systematically, reinforced host defenses against S. pneumoniae. The present invention thus relates to the use of short-chain fatty acids for the treatment of bacterial superinfections post-influenza.

Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of secondary bacterial infections, preferably secondary respiratory infections.

Abstract: A corrosion-resistant, hot and cold formable and weldable steel for use in hydrogen-induced technology with high resistance to hydrogen embrittlement has the following composition: 0.01 to 0.4 percent by mass of carbon, ?3.0 percent by mass of silicon, 0.3 to 30 percent by mass of manganese, 10.5 to 30 percent by mass of chromium, 4 to 12.5 percent by mass of nickel, ?1.0 percent by mass of molybdenum, ?0.2 percent by mass of nitrogen, 0.5 to 8.0 percent by mass of aluminum, ?4.0 percent by mass of copper, ?0.1 percent by mass of boron, ?1.0 percent by mass of tungsten, ?5.0 percent by mass of cobalt, ?0.5 percent by mass of tantalum, ?2.0 percent by mass of at least one of the elements: niobium, titanium, vanadium, hafnium and zirconium, ?0.3 percent by mass of at least one of the elements: yttrium, scandium, lanthanum, cerium and neodymium, the remainder being iron and smelting-related steel companion elements.

Abstract: To relieve signaling congestion, UEs (30) having delay-tolerant data are moved more rapidly to the non UL synchronized state, freeing up PUCCH resources for users that have not indicated a delay-tolerance. In one embodiment, a resource conservative mode is defined for a UE (30) having delay-tolerant data (e.g., from a “background” app); otherwise, the UE (30) assumes a default mode. In one embodiment, the network sends the UE a pair of first and a second values (or indices to them) for a Time Alignment Timer, TAT (56, 66) in the UE (30). The first value—which is typically smaller than the second value—is used by the UE (30) in the resource conservative mode when the user data plane is internally concluded as being delay-tolerant or has already been confirmed to be delay-tolerant; the second value is used otherwise (i.e., in default mode). In the resource conservative mode, the shorter TAT value moves the UE from PUCCH more rapidly, and the UE (30) uses random access for infrequent scheduling requests.

Abstract: To relieve signaling congestion, UEs (30) having delay-tolerant data are moved more rapidly to the non UL synchronized state, freeing up PUCCH resources for users that have not indicated a delay-tolerance. In one embodiment, a resource conservative mode is defined for a UE (30) having delay-tolerant data (e.g., from a “background” app); otherwise, the UE (30) assumes a default mode. In one embodiment, the network sends the UE a pair of first and a second values (or indices to them) for a Time Alignment Timer, TAT (56, 66) in the UE (30). The first value—which is typically smaller than the second value—is used by the UE (30) in the resource conservative mode when the user data plane is internally concluded as being delay-tolerant or has already been confirmed to be delay-tolerant; the second value is used otherwise (i.e., in default mode). In the resource conservative mode, the shorter TAT value moves the UE from PUCCH more rapidly, and the UE (30) uses random access for infrequent scheduling requests.

Abstract: A corrosion-resistant, hot and cold formable and weldable steel for use in hydrogen-induced technology with high resistance to hydrogen embrittlement has the following composition: 0.01 to 0.4 percent by mass of carbon, ?3.0 percent by mass of silicon, 0.3 to 30 percent by mass of manganese, 10.5 to 30 percent by mass of chromium, 4 to 12.5 percent by mass of nickel, ?1.0 percent by mass of molybdenum, ?0.2 percent by mass of nitrogen, 0.5 to 8.0 percent by mass of aluminum, ?4.0 percent by mass of copper, ?0.1 percent by mass of boron, ?1.0 percent by mass of tungsten, ?5.0 percent by mass of cobalt, ?0.5 percent by mass of tantalum, ?2.0 percent by mass of at least one of the elements: niobium, titanium, vanadium, hafnium and zirconium, ?0.3 percent by mass of at least one of the elements: yttrium, scandium, lanthanum, cerium and neodymium, the remainder being iron and smelting-related steel companion elements.