Patents by Inventor Max N. Moore

Max N. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apparatus for synthesizing oligonucleotides and methods of use
    Patent number: 9034272
    Abstract: The present invention relates to apparatus and methods for synthesizing oligonucleotides wherein a reaction zone has a variable volume based on the position of a piston, and the piston is adjusted to control the amount of headspace above solid support in the reaction zone. Methods and apparatus that limit the size or existence of the headspace are described.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: May 19, 2015
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Isaiah E. Cedillo, Max N. Moore, Francis J. Ring
  • APPARATUS FOR SYNTHESIZING OLIGONUCLEOTIDES AND METHODS OF USE
    Publication number: 20120107181
    Abstract: The present invention relates to apparatus and methods for synthesizing oligonucleotides wherein a reaction zone has a variable volume based on the position of a piston, and the piston is adjusted to control the amount of headspace above solid support in the reaction zone. Methods and apparatus that limit the size or existence of the headspace are described.
    Type: Application
    Filed: May 28, 2010
    Publication date: May 3, 2012
    Inventors: Isaiah E. Cedillo, Max N. Moore, Francis J. Ring
  • Oligonucleotide synthesis with alternative solvents
    Patent number: 7276599
    Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: October 2, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Max N. Moore, Mark Andrade, Recaldo Carty, Anthony Scozzari, Achim Krotz
  • Processes of purifying oligonucleotides
    Patent number: 6632938
    Abstract: Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an oligonucleotide aggregate and isolating the oligonucleotide aggregate to produce a purified oligonucleotide.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: October 14, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Max N. Moore, John Charles Arthur, Kent Vansooy, Anthony N. Scozzari
  • Processes of purifying oligonucleotides
    Publication number: 20030055241
    Abstract: Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an oligonucleotide aggregate and isolating the oligonucleotide aggregate to produce a purified oligonucleotide.
    Type: Application
    Filed: June 7, 2001
    Publication date: March 20, 2003
    Inventors: Max N. Moore, John Charles Arthur, Kent Vansooy, Anthony N. Scozzari