Patents by Inventor Maximilian Lewis Seel
Maximilian Lewis Seel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9518982Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.Type: GrantFiled: November 3, 2009Date of Patent: December 13, 2016Assignee: GENERAL ELECTRIC COMPANYInventors: Anup Sood, Michael Christopher Montalto, Michael Gerdes, Maximilian Lewis Seel, Robert John Filkins
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Patent number: 8822147Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.Type: GrantFiled: April 27, 2012Date of Patent: September 2, 2014Assignee: General Electric CompanyInventors: Anup Sood, Michael Christopher Montalto, Michael Gerdes, Maximilian Lewis Seel, Robert John Filkins
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Publication number: 20140045251Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.Type: ApplicationFiled: October 23, 2013Publication date: February 13, 2014Applicant: General Electric CompanyInventors: Anup Sood, Michael Christopher Montalto, Michael John Gerdes, Maximilian Lewis Seel, Robert John Filkins
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Publication number: 20120231967Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.Type: ApplicationFiled: April 27, 2012Publication date: September 13, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Anup Sood, Michael Christopher Montalto, Michael Gerdes, Maximilian Lewis Seel, Robert John Filkins
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Patent number: 8060348Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.Type: GrantFiled: November 30, 2006Date of Patent: November 15, 2011Assignee: General Electric CompanyInventors: Harvey Ellis Cline, Ali Can, Xiaodong Tao, Robert John Filkins, Maximilian Lewis Seel, Michael Christopher Montalto
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Publication number: 20100047925Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.Type: ApplicationFiled: November 3, 2009Publication date: February 25, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Anup Sood, Michael Christopher Montalto, Michael Gerdes, Maximilian Lewis Seel, Robert John Filkins
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Patent number: 7629125Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.Type: GrantFiled: November 16, 2006Date of Patent: December 8, 2009Assignee: General Electric CompanyInventors: Anup Sood, Michael Christopher Montalto, Michael Gerdes, Maximilian Lewis Seel, Robert John Filkins
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Publication number: 20080118916Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.Type: ApplicationFiled: November 16, 2006Publication date: May 22, 2008Applicant: GENERAL ELECTRIC COMPANYInventors: ANUP SOOD, MICHAEL CHRISTOPHER MONTALTO, MICHAEL GERDES, MAXIMILIAN LEWIS SEEL, ROBERT JOHN FILKINS
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Publication number: 20080033657Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.Type: ApplicationFiled: November 30, 2006Publication date: February 7, 2008Inventors: Harvey Ellis Cline, Ali Can, Xiaodong Tao, Robert John Filkins, Maximilian Lewis Seel, Michael Christopher Montalto