Abstract: The present disclosure relates in part to sterically hindered N-aliphatic N-heterocyclic carbene (NHC) ligands, which are readily synthetically available from inexpensive starting materials. The present disclosure further relates to NHC catalyst complexes comprising transition metals such as Cu, Ag, Au, and Pd. Furthermore, the present disclosure provides methods for using the catalysts described herein in a number of organic transformations, including alkyne hydroboration and hydration, in addition to C—O, C—C, and C—N coupling reactions.

Abstract: A method includes receiving stress-related measurements collected by one or more stress sensors, where the stress-related measurements represent one or more physiological responses of a user to a stressor. The method also includes receiving context data collected by one or more context sensors, where the context data represents a context associated with the user. The method further includes determining stress profile features associated with the user based on the stress-related measurements. The method also includes providing the stress profile features to a trained stress profile identification machine learning model to select a stress profile from among multiple candidate stress profiles for association with the user. The method further includes providing the selected stress profile and the context data to a trained stress intervention recommendation machine learning model to select a stress intervention activity for the user.

Abstract: In particular embodiments, a method includes accessing, by a computing device, sensor data from a sensor of a client device corresponding to a user. The method further includes determining one or more segments of sensor data and selecting at least one segment of sensor data. The method further concludes determining, based at least on the selected segments of sensor data, one or more features corresponding to the user's pulmonary condition. The method further includes determining, based at least on the determined features, an assessment of the user's pulmonary condition.

Abstract: A method includes estimating, by a consumer electronic device, an atrial fibrillation (AF) burden of a subject based on multiple measurements passively collected by at least one sensor associated with the consumer electronic device while the subject is in a free-living environment. The method also includes outputting, by the consumer electronic device, an AF burden notification associated with the subject based on the estimated AF burden. The method further includes outputting, by the consumer electronic device, an AF burden recommendation based on the estimated AF burden.

Abstract: A method includes receiving, by an electronic device, sensor data during a spirometry test of a user, the sensor data comprising audio data of the user and distance data of a distance from a face of the user to the electronic device. The method also includes obtaining, by the electronic device, an amount of air volume exchange and at least one pulmonary health parameter that are determined based on the audio data and the distance data. The method also includes presenting an indicator on a display of the electronic device for use by the user or a medical provider, the indicator representing the amount of air volume exchange.

Abstract: A method includes obtaining at least one breathing audio sample of a user captured using earbuds worn by the user. The method also includes converting the at least one breathing audio sample to a breathing spectrogram configured as an image. The method further includes processing the breathing spectrogram using a trained multi-task convolutional neural network (CNN) to identify a breathing rate and a breathing depth of the user. In addition, the method includes outputting the breathing rate and the breathing depth of the user.

Abstract: In one embodiment, a method includes accessing, from a first sensor of a wearable device, motion data representing motion of a user and determining, from the motion data, an activity level of the user. The method includes selecting, based on the activity level, an activity-based technique for estimating the breathing rate of the user, which is used to determine a breathing rate of the user. The method further includes determining a quality associated with the breathing rate and comparing the determined quality with a threshold. If the determined quality is not less than the threshold, then the method includes using the determined breathing rate as a final breathing-rate determination for the user. If the determined quality is less than the threshold, then the method includes activating a second sensor of the wearable device and determining, based on data from the second sensor, a breathing rate for the user.

Abstract: Detecting an adverse health event and responding to an emergency event can include updating a current context profile of a user based on signals generated by one or more sensors of a device, the signals generated in response to one or more physically measurable phenomena associated with the user. A context-aware baseline profile having a same context as the current context profile can be selected, the context-aware baseline profile selected from a plurality of context-aware baseline profiles having different contexts. Features of the current context profile can be compared with corresponding features of the context-aware baseline profile of the user having the same context as the current context profile. A remedial action can be initiated in response to recognizing, based on the comparing, an occurrence of a possible adverse health event affecting the user.

Abstract: A method includes obtaining, by an electronic device, an audio segment comprising one or more audio events of a target subject. The method also includes extracting, by the electronic device, audio embeddings from the one or more audio events using an embedding model, the embedding model comprising a trained machine learning model. The method further includes comparing, by the electronic device, the extracted audio embeddings with a match profile of the target subject, the match profile generated during an enrollment stage. The method also includes generating, by the electronic device, a label for the audio segment based on whether or not the extracted audio embeddings match the match profile, wherein the label enables correlation of the audio segment with the target subject for monitoring a health condition of the target subject.

Abstract: A method includes receiving multimodal data collected using at least one wearable device during an assessment window. The method also includes extracting biomarker features from the multimodal data, based on changes in the extracted biomarker features. The method also includes detecting that a stress event occurred during the assessment window. The method also includes accessing a plurality of templates of patterns in biomarker features, wherein a first subset of the templates is associated with unhealthy response to stress and a second subset of the templates is associated with healthy response to stress. The method also includes determining whether the stress event corresponds to a healthy response or an unhealthy response based on similarities between a pattern in the extracted biomarker features and the plurality of templates. The method also includes responsive to the stress event corresponding to an unhealthy response, providing a stress management recommendation.

Abstract: Detecting and identifying a predetermined health event can include detecting a potential occurrence of the predetermined health event for a user by processing in real-time motion signals corresponding to motion of the user. A likelihood that the potential occurrence is an actual occurrence of the predetermined health event can be determined based on template matching of the motion signals. In response to determining that the likelihood exceeds a predetermined threshold, audio signals coinciding in time with the motion of the user can be processed using one or more layers of a multilayered audio event classifier.

Abstract: Continuously monitoring heart rhythm can include grouping, using computer hardware, a plurality of inter-beat intervals (IBI) data for a user into a plurality of epochs, wherein each epoch includes a subset of the IBI data corresponding to a predetermined time span. For each epoch, a selected feature set selected from a plurality of feature sets is extracted based on a determination of temporal consistency of the epoch. A plurality of epoch classifications may be generated for the epochs using a selected feature processor, wherein each epoch classification indicates whether arrhythmia is detected for the epoch from which the epoch classification is generated. The selected feature processor is selected from a plurality of different feature processors on a per-epoch basis based on the selected feature set extracted from the epoch. An indication of arrhythmia may be output, via an output device of the computer hardware, based on the epoch classifications.

Abstract: Device-invariant, frequency-domain signal processing with machine learning includes retrieving with a host device a device-specific alien dataset corresponding to an alien device. The device-specific alien dataset is retrieved from a remote data storage device communicatively coupled with the host device. A plurality of frequency-domain features are extracted from the device-specific alien dataset and a machine learning model is trained using the plurality of frequency-domain features. The host device extracts frequency-domain features from signals generated by sensors operatively coupled with the host device. Real-time frequency bin adaptation of the frequency-domain features extracted by the host device is performed. Based on the frequency-domain features extracted by the host device, as adapted, an inference is performed using the machine learning model.

Abstract: Pulmonary assessment based on speech can include identifying one or more audio features and speech patterns of a user's speech. A cognitive burden associated with the user's speech can be determined.

Abstract: A method for pulmonary condition monitoring includes selecting a phrase from an utterance of a user of an electronic device, wherein the phrase matches an entry of multiple phrases. At least one speech feature that is associated with one or more pulmonary conditions within the phrase is identified. A pulmonary condition is determined based on analysis of the at least one speech feature.

Abstract: Continuously monitoring heart rhythm can include grouping, using computer hardware, a plurality of inter-beat intervals (IBI) data for a user into a plurality of epochs, wherein each epoch includes a subset of the IBI data corresponding to a predetermined time span. For each epoch, a selected feature set selected from a plurality of feature sets is extracted based on a determination of temporal consistency of the epoch. A plurality of epoch classifications may be generated for the epochs using a selected feature processor, wherein each epoch classification indicates whether arrhythmia is detected for the epoch from which the epoch classification is generated. The selected feature processor is selected from a plurality of different feature processors on a per-epoch basis based on the selected feature set extracted from the epoch. An indication of arrhythmia may be output, via an output device of the computer hardware, based on the epoch classifications.

Abstract: A method includes estimating, by a consumer electronic device, an atrial fibrillation (AF) burden of a subject based on multiple measurements passively collected by at least one sensor associated with the consumer electronic device while the subject is in a free-living environment. The method also includes outputting, by the consumer electronic device, an AF burden notification associated with the subject based on the estimated AF burden. The method further includes outputting, by the consumer electronic device, an AF burden recommendation based on the estimated AF burden.

Abstract: A method includes identifying, by an electronic device, one or more segments within a first audio recording that includes one or more non-speech segments and one or more speech segments. The method also includes generating, by the electronic device, one or more synthetic speech segments that include natural speech audio characteristics and that preserve one or more non-private features of the one or more speech segments. The method also includes generating, by the electronic device, an obfuscated audio recording by replacing the one or more speech segments with the one or more synthetic speech segments while maintaining the one or more non-speech segments, wherein the one or more synthetic speech segments prevent recognition of some content of the obfuscated audio recording.

Abstract: A method for contextually aware determination of respiration includes obtaining, by an electronic device, context information and selecting, by the electronic device, a set of sensor data associated with respiratory activity of a subject, based on the context information. The method further includes selecting, based on the selected set of sensor data, an algorithm from a plurality of algorithms for determining a respiration rate of the subject, and determining, by applying the selected algorithm to the selected set of sensor data associated with respiratory activity of the subject, the respiration rate for the subject.

Abstract: Passively monitoring a user's breathing with a device can include identifying breathing modes of the user's breathing and responsive to detecting a trigger mode based on the identifying, generating an instruction adapted to the trigger mode. The instruction can be conveyed to the user via the device. The monitoring can include determining phases of the user's breathing with the device. Determining the phases can include receiving acoustic signals generated by an acoustic sensor in response to a user's breathing and generating acoustic data comprising features extracted from the acoustic signals. Phases of the user's breathing can be determined by classifying the acoustic data using a machine learning model trained based on signal processing of motion signals generated by a motion sensor in response to human breathing motions. Though trained using signal processing of motion signals, the machine learning model is trained to classify acoustic data.