Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Eyewear having heating elements therewith which may be used for safety, sports, and the like. The eyewear may provide features which reduce or eliminate fogging and condensation on the eyewear when a heating element in the lens is activated. The eyewear also includes adjustable features to provide greater comfort.

Abstract: Eyewear having an enhanced fit which may be used for safety, sports, and the like. The eyewear may provide features which permit enhanced airflow and an enhanced fit to a user's face. Such features may include greater adjustability to provide greater comfort. Eyewear including an RFID tag which is activated to send or receive transmissions when the eyewear is unfolded and/or positioned in a position to be worn by a user.

Abstract: Eyewear having adapters and/or mask attachment features which permit the eyewear to attach to a mask, or a mask to attach to the eyewear. An adapter may be used which may provide a portion of the eyewear and/or mask. Alternatively, an adapter may be provided separately. Finally, a flap adapter may be used to extend facial protection for eyewear.

Abstract: Eyewear having an enhanced air flow and/or absorption features which may be used for safety, sports, and the like. The eyewear may desirably provides features in design and/or function of the structure to enhance air flow and reduce moisture. Additional elements such as removable pads and/or cartridges may be used with the eyewear to enhanced airflow and reduce moisture adjacent a user's eyes and face as well.

Abstract: A shirt collar for dress or sport shirts with an adjustable collar secured to the shirt body by a collar stand. An elongated fabric strip positioned within a fold in the collar band with one end projecting through a slot and with a button secured to its end and with the other end connected to an elastic strip, in turn secured to the collar band. The button may be engaged with the button hole on the other side of the collar band.

Abstract: A shirt collar for dress or sport shirts with an adjustable collar secured to the shirt body by a collar stand. An elongated fabric strip positioned within a fold in the collar band with one end projecting through a slot and with a button secured to its end and with the other end connected to an elastic strip, in turn secured to the collar band. The button may be engaged with the button hole on the other side of the collar band.

Abstract: A probe type instrument to characterize tissue type that combines optical and electrical tests in a single device capable of providing data of both types almost simultaneously from very small, e.g. 3-10 mm diameter, areas of tissue surface. Key to this approach is an instrument capable of making almost simultaneous electrical and optical measurements on the same small areas of tissue, before being moved to scan adjacent tissue areas. In the preferred operation of the system fourteen measurement cycles are performed per second and each measurement involves a complex sequence of events, including (1) three optical and fifteen electrical tissue stimulations with subsequent detection, filtering and digitization of the tissue response; (2) extraction of specific parameters from the optical and electrical signals; (3) checking for errors, and subsequent classification of the extracted parameters into various tissue type categories; and (4) feedback to the system operator.