Abstract: The present invention relates to an oral solid dosage form comprising N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof as an active ingredient, which has good dissolution and storage-stability. When the oral solid dosage form is a tablet, the tablet can be prepared while inhibiting tableting troubles from low content to high content of the active ingredient.

Abstract: An automatic analysis apparatus includes: an automatic analysis unit 100 which includes a dispensing mechanism including a probe which is configured to dispense a sample or a reagent into a reaction container, a cleaning mechanism; and a control unit 124. The control unit includes a storage unit 124a configured to store count values which indicate weightings to contamination and are set in advance in accordance with a plurality of analysis conditions, a processing unit 124b configured to obtain a cumulative count for each dispensing of the sample or the reagent on the basis of the stored count values and to determine whether the obtained cumulative count exceeds a threshold value set in advance, and an instruction unit 124c configured to instruct an operation of the cleaning mechanism to clean the probe when a result of determination is that the cumulative count exceeds the threshold value.

Abstract: Disclosed are a novel method of screening for insulin secretion-potentiating agents as well as means for performing such screening. The means include a DNA encoding fluorescent-labeled Epac2 comprising two different DNAs encoding two different fluorescent proteins which emit fluorescent light with wavelength differing from each other and a DNA encoding Epac2 which are fused together in-frame, and the cells transformed with the DNA. Also disclosed is a method of screening insulin secretion-potentiating agents comprising bringing a candidate compound into contact with cells transformed with the said DNA, and detecting whether the compound binds to Epac2.

Abstract: A heterologous chimeric animal can be produced by a method comprising the steps of: (A) injecting a stem cell into a blastocyst cavity in a blastocyst stage of an animal heterologous to that of the stem cell, or mixing the stem cell with a divided fertilized egg of the animal heterologous to that of the stem cell; and (B) growing a cell mass including the stem cell prepared in the step (A) into a chimeric animal between a species of the stem cell and a species of the heterologous animal.

Abstract: A laminated optical film according to an embodiment of the present invention includes a long polarizer having an absorption axis in a lengthwise direction and a long optical compensation film. An angle formed by a slow axis of the optical compensation film and the absorption axis of the polarizer is 5 to 85°.

Abstract: An alcoholic beverage containing an extract of maca having various excellent properties is provided. The maca extract-containing alcoholic beverage is easy to drink because a distinctive odor of the extract of maca is decreased. Such a maca extract-containing alcoholic beverage contains an extract of maca and a distilled liquor mainly made from fermented muscat grapes and containing 1 to 400 ppm of acetic acid with respect to the amount of pure alcohol contained therein. Specifically, 1 part by weight of the extract of maca is added to 0.5 to 1,000 parts by weight of the distilled liquor.

Abstract: The present invention provides an efficient extraction method of Maca extract having safe anti-allergic effects enabling long-term intake, and a food and beverage product, a perfumery and a cosmetic as well as a pharmaceutical preparation comprising thus obtained Maca extract showing anti-allergic effect. In the provided extraction method of Maca extract, the temperature of extracting solution is from 20° C. to 75° C. when Maca extract is extracted by adding aqueous solution containing ethanol being ethanol concentration of from 20 to 100 by volume %.

Abstract: A disposable diaper including a liquid permeable topsheet, a liquid impermeable backsheet, and an absorbent member interposed therebetween, the disposable diaper being provided with a front waist body portion which is located on the stomach side of a diaper wearer when the wearer puts on the diaper and a rear waist body portion which is located on the back side of the wearer, the rear waist body portion being provided with tape tabs connected at opposite lateral sides thereof, respectively, each of the tape tabs being provided with a projection member or a recess member of a mechanical fastener, the front waist body portion being provided with a counterpart portion on the backsheet side for allowing the projection member or the recess member to be engaged with or be retained by the counterpart portion;each of the tape tabs including an adhesive portion which is formed by applying an adhesive agent thereto;the adhesive portion being provided on the surface side of the tape tab opposite to where the projection