Patents by Inventor Mehdi Abedi
Mehdi Abedi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230204513Abstract: A method of detecting a pathogen in a sample, comprising: mixing at least a portion of the sample with a plurality of capture particles functionalized with a molecular recognition element exhibiting specific binding to said pathogen to capture at least a portion of pathogen particles when present in the sample; exposing said captured pathogen particles to at least two fluorescent dyes, which emit fluorescent radiation at two different wavelengths in response to excitation, such that live pathogen particles among said captured pathogen particles are preferentially stained with one of the dyes and dead pathogen particles among said captured pathogen particles are preferentially stained with the other dye; irradiating the captured stained pathogen particles with excitation radiation to excite said fluorescent dyes; and detecting fluorescent radiation emitted by said excited fluorescent dyes; and distinguishing said live pathogen particles from said dead pathogen particles based on wavelengths of the detected fluType: ApplicationFiled: December 5, 2022Publication date: June 29, 2023Applicant: IntelliFoods Labs, LLCInventors: Mohammad E. Taslim, Mehdi Abedi, Ramin M. Hakami, Michael Mojaver, Reza Mollaaghababa, Edward A. Greenfield
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Publication number: 20220213528Abstract: In one aspect, a method of detecting a pathogen, e.g., Listeria bacterium, Chlamydia bacteria, gonorrhea bacteria and/or HPV, in a sample is disclosed, which comprises bringing a sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to the pathogen, monitoring electrical resistance of said antibody-functionalized graphene layer in response to interaction with said sample, and detecting presence of the pathogen in said sample by detecting a change in said electrical resistance indicative of interaction of the pathogen with said antibody-functionalized graphene layer. For example, a decrease of the electrical resistance of the graphene layer can indicate the presence of the pathogen in the sample under study. In some embodiments, a method according to the present teachings is capable of detecting pathogens, such as Listeria bacteria, Chlamydia bacteria, gonorrhea bacteria and HPV in a sample at a concentration as low as 4 cfu per 100 grams of a sample.Type: ApplicationFiled: October 19, 2021Publication date: July 7, 2022Inventors: Mohammed FOTOUHI, Mohammad E. TASLIM, Mehdi ABEDI, Edward Alvin Greenfield, Reza MOLLAAGHABABA, Namal NAWANA
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Publication number: 20220196631Abstract: The present teachings are generally directed to sensors that employ antibody-functionalized graphene nano-flakes (and/or a graphdiyne layer) for detecting a variety of analytes in a variety of samples. A plurality of graphene nano-flakes (and/or a graphdiyne layer) can be deposited on a underlying substrate, e.g., in the form of a single layer or multiple stacked layers, and functionalized with an antibody that specifically binds with an analyte of interest. A sample under investigation can be introduced onto the antibody-functionalized graphene nano-flakes (and/or a graphdiyne layer). The interaction of the analyte of interest, if present in the sample, with the antibody-functionalized graphene nano-flakes (and/or a graphdiyne layer) can mediate a change in at least one electrical property of the graphene nano-flakes, e.g., their DC electrical resistance. An analyzer can detect such a change and analyze it to determine whether the analyte is present in the sample.Type: ApplicationFiled: December 4, 2021Publication date: June 23, 2022Inventors: Namal NAWANA, Mehdi ABEDI, Mohammad E. TASLIM, Mohammed FOTOUHI, Edward A. GREENFIELD
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Publication number: 20220196666Abstract: The present teachings are generally directed to sensors that employ antibody- and/or aptamer-functionalized graphene layer (or graphene flakes and/or graphdiyne layer) for detecting a prostate-specific biomarker in a sample. A graphene layer can be deposited on a underlying substrate and functionalized with an antibody and/or aptamer that specifically binds with an analyte of interest (e.g., a prostate-specific biomarker). A sample under investigation can be introduced onto the functionalized graphene layer. The interaction of the analyte of interest, if present in the sample, with the functionalized graphene layer can mediate a change in at least one electrical property of the graphene layer, e.g., their DC electrical resistance. An analyzer can detect such a change and analyze it to determine whether the analyte is present in the sample. In some embodiments, calibration methods can be employed to quantify the analyte present in the sample.Type: ApplicationFiled: December 4, 2021Publication date: June 23, 2022Inventors: Mehdi Abedi, Namal Nawana, Mohammad E. Taslim, Mohammed Fotouhi, Edward A. Greenfield
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Patent number: 11357219Abstract: In one aspect, a trap for capturing a marine animal, e.g., a lobster, is disclosed, which includes a housing having an inlet port for receiving a marine animal, said inlet port being configured to prevent the marine animal from leaving the container, and a sensor coupled to the housing for detecting the presence of the marine animal in the housing. In some embodiments, a stretchable netting is coupled to the inlet port such that the marine animal passes through the netting before entering the housing via the inlet port. A stretch detector can be coupled to the netting to register the passage of a marine animal via the netting into the housing. The passage of a marine animal through the netting can result in a stretch of the netting, which is registered by the stretch signal. The stretch signal indicates the passage of the marine animal into the housing.Type: GrantFiled: February 10, 2020Date of Patent: June 14, 2022Inventors: Mehdi Abedi, Reza Mollaaghababa
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Patent number: 11209416Abstract: Methods and devices for detecting a target agent of interest, e.g., a pathogen, in a sample are described herein. In some embodiments, a sensor is provided that can include a substrate, a graphene layer disposed on a surface of said substrate, and a protein bound to said graphene layer. The protein can be capable of binding to one or more target agents of interest, e.g., pathogens, etc. The binding of the protein to the one or more target agents of interest can generate a change in an electrical property of the graphene layer.Type: GrantFiled: July 26, 2018Date of Patent: December 28, 2021Assignee: Graphene-DX, Inc.Inventors: Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Bahram Fotouhi, Kashayar Javaherian, Edward Alvin Greenfield, Namal Nawana
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Patent number: 11149318Abstract: In one aspect, a method of detecting a pathogen, e.g., listeria bacterium, chlamydia bacteria, gonorrhea bacteria and/or HPV, in a sample is disclosed, which comprises bringing a sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to the pathogen, monitoring electrical resistance of said antibody-functionalized graphene layer in response to interaction with said sample, and detecting presence of the pathogen in said sample by detecting a change in said electrical resistance indicative of interaction of the pathogen with said antibody-functionalized graphene layer. For example, a decrease of the electrical resistance of the graphene layer can indicate the presence of the pathogen in the sample under study. In some embodiments, a method according to the present teachings is capable of detecting pathogens, such as listeria bacteria, chlamydia bacteria, gonorrhea bacteria and HPV in a sample at a concentration as low as 4 cfu per 100 grams of a sample.Type: GrantFiled: January 29, 2019Date of Patent: October 19, 2021Assignee: GRAPHENE-DX, INC.Inventors: Mohammed Fotouhi, Mohammad E. Taslim, Mehdi Abedi, Edward Alvin Greenfield, Reza Mollaaghababa, Namal Nawana
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Publication number: 20210293816Abstract: In one aspect, a sensor for detecting SARS-CoV-2 virus in a sample, e.g., a blood sample, is disclosed, which includes a graphene layer, a plurality of binding agents coupled to said graphene layer to generate a functionalized graphene layer, where the binding agents exhibit specific binding to at least one epitope of SARS-CoV-2 virus, and a plurality of electrical conductors electrically coupled to said functionalized graphene layer for measuring an electrical property (e.g., DC electrical resistance) of the functionalized graphene layer. While in some embodiments such binding agents are monoclonal antibodies, in other embodiments they can be polyclonal antibodies.Type: ApplicationFiled: March 22, 2021Publication date: September 23, 2021Inventors: Namal Nawana, Reza Mollaaghababa, Mehdi Abedi, Edward Alvin Greenfield, Nirva Patel, Mohammed Fotouhi
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Publication number: 20210247409Abstract: In one aspect, a sensor for detecting hemoglobin protein (e.g., human hemoglobin protein) in a sample is disclosed, which includes a graphene layer, a plurality of binding agents coupled to said graphene layer to generate a functionalized graphene layer, where the binding agents exhibit specific binding to a hemoglobin protein (e.g., to human hemoglobin protein) and a plurality of electrical conductors electrically coupled to said functionalized graphene layer for measuring an electrical property (e.g., DC electrical resistance) of said functionalized graphene layer. While in some embodiments such binding agents are monoclonal antibodies, in other embodiments they can be polyclonal antibodies.Type: ApplicationFiled: February 8, 2021Publication date: August 12, 2021Inventors: Namal NAWANA, Mehdi Abedi, Reza Mollaaghababa
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Publication number: 20210223271Abstract: In one aspect, a sensor for detecting a drug of abuse (DOA) in a sample is disclosed. In some embodiments, the sensor includes a graphene layer, a plurality of binding agents, which bind to the DOA, coupled to said graphene layer to generate a functionalized graphene layer, and a plurality of electrical conductors electrically coupled to said functionalized graphene layer for measuring an electrical property of said functionalized graphene layer. While in some embodiments, such binding agents are monoclonal antibodies, in other embodiments they are polyclonal antibodies.Type: ApplicationFiled: January 19, 2021Publication date: July 22, 2021Inventors: Namal Nawana, Mehdi Abedi, Reza Mollaaghababa
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Publication number: 20210102937Abstract: A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.Type: ApplicationFiled: September 21, 2020Publication date: April 8, 2021Inventors: Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Bahram Fotouhi, Kashayar Javaherian, Edward Alvin Greenfield, Namal Nawana
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Publication number: 20200300845Abstract: In one aspect, a method of detecting tetrahydrocannabinol (THC) in a sample is disclosed, which comprises bringing the sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to THC, applying a time-varying electric field to said antibody-functionalized graphene layer, monitoring electrical resistance of said graphene layer in response to interaction with said sample, and detecting presence of THC in the sample by detecting a change in said electrical resistance indicative of interaction of THC with said anti-body functionalized graphene layer.Type: ApplicationFiled: April 10, 2020Publication date: September 24, 2020Inventors: Mohammed Fotouhi, Mehdi Abedi, Edward Alvin Greenfield, Reza Mollaaghababa, Mohammad E. Taslim
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Patent number: 10782285Abstract: A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.Type: GrantFiled: May 24, 2019Date of Patent: September 22, 2020Assignee: Rite Taste, LLCInventors: Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Bahram Fotouhi, Kashayar Javaherian, Edward Alvin Greenfield, Namal Nawana
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Publication number: 20200253177Abstract: In one aspect, a trap for capturing a marine animal, e.g., a lobster, is disclosed, which includes a housing having an inlet port for receiving a marine animal, said inlet port being configured to prevent the marine animal from leaving the container, and a sensor coupled to the housing for detecting the presence of the marine animal in the housing. In some embodiments, a stretchable netting is coupled to the inlet port such that the marine animal passes through the netting before entering the housing via the inlet port. A stretch detector can be coupled to the netting to register the passage of a marine animal via the netting into the housing. The passage of a marine animal through the netting can result in a stretch of the netting, which is registered by the stretch signal. The stretch signal indicates the passage of the marine animal into the housing.Type: ApplicationFiled: February 10, 2020Publication date: August 13, 2020Inventors: Mehdi Abedi, Reza Mollaaghababa
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Publication number: 20200011860Abstract: In one aspect, the present teachings provide a sensor for detecting troponin, e.g., cardiac troponin in a patient's blood, that relies on an electronic signature generated via interaction of troponin with an anti-troponin antibody. More specifically, as discussed in more detail below, such a sensor can include a graphene layer disposed on an underlying substrate, where the graphene layer has been functionalized with an anti-troponin antibody. The interaction of troponin in a sample, e.g., a patient's blood, with the anti-troponin antibody coupled, e.g., anchored, to the graphene substrate, can modulate an electronic property of the underlying graphene layer. The modulation of the electronic property of the graphene layer can be measured and used to identify, and in some embodiments quantify, troponin in the sample.Type: ApplicationFiled: May 24, 2019Publication date: January 9, 2020Inventors: Namal Nawana, Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Edward Alvin Greenfield
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Publication number: 20190317081Abstract: A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.Type: ApplicationFiled: May 24, 2019Publication date: October 17, 2019Inventors: Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Bahram Fotouhi, Kashayar Javaherian, Edward Alvin Greenfield, Namal Nawana
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Publication number: 20190284615Abstract: In one aspect, a method of detecting a pathogen, e.g., listeria bacterium, chlamydia bacteria, gonorrhea bacteria and/or HPV, in a sample is disclosed, which comprises bringing a sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to the pathogen, monitoring electrical resistance of said antibody-functionalized graphene layer in response to interaction with said sample, and detecting presence of the pathogen in said sample by detecting a change in said electrical resistance indicative of interaction of the pathogen with said antibody-functionalized graphene layer. For example, a decrease of the electrical resistance of the graphene layer can indicate the presence of the pathogen in the sample under study. In some embodiments, a method according to the present teachings is capable of detecting pathogens, such as listeria bacteria, chlamydia bacteria, gonorrhea bacteria and HPV in a sample at a concentration as low as 4 cfu per 100 grams of a sample.Type: ApplicationFiled: January 29, 2019Publication date: September 19, 2019Inventors: Mohammed Fotouhi, Mohammad E. Taslim, Mehdi Abedi, Edward Alvin Greenfield, Reza Mollaaghababa, Namal Nawana
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Patent number: 10401352Abstract: A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.Type: GrantFiled: November 21, 2016Date of Patent: September 3, 2019Assignee: Rite Taste, LLCInventors: Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Bahram Fotouhi, Kashayar Javaherian, Edward Alvin Greenfield
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Publication number: 20190079068Abstract: Methods and devices for detecting a target agent of interest, e.g., a pathogen, in a sample are described herein. In some embodiments, a sensor is provided that can include a substrate, a graphene layer disposed on a surface of said substrate, and a protein bound to said graphene layer. The protein can be capable of binding to one or more target agents of interest, e.g., pathogens, etc. The binding of the protein to the one or more target agents of interest can generate a change in an electrical property of the graphene layer.Type: ApplicationFiled: July 26, 2018Publication date: March 14, 2019Inventors: Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Bahram Fotouhi, Kashayar Javaherian, Edward Alvin Greenfield, Namal Nawana
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Patent number: 9664674Abstract: A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.Type: GrantFiled: October 2, 2015Date of Patent: May 30, 2017Assignee: Rite Taste, LLCInventors: Mohammad E. Taslim, Mohammed Fotouhi, Mehdi Abedi, Reza Mollaaghababa, Bahram Fotouhi, Kashayar Javaherian, Edward Alvin Greenfield