Abstract: The present disclosure relates to techniques for direct data connection (DDC) for universal collection of clinical trial health data. Particularly, aspects are directed to obtaining, by an application programming interface of a DDC system, health data for a subject from a site. The DDC system determines a visit status of the subject associated with the health data. The DDC system determines a form for the subject that is to be completed for capturing the health data. The DDC system maps data elements of the health data in the site specific format to data elements of the form in an electronic data capture format and establishes instructions for translating the data elements to the electronic data capture format. The DDC system translates the data elements based on the instructions and communicates information to an electronic data capture system.