Abstract: A method and a device to identify the material type of particles in a liquid are provided. The device is a microfluidic platform with a liquid channel for the material identification of a particle, the microfluidic platform includes electrodes forming a low-frequency sensor for measuring the geometric size of a particle passing through the liquid channel and electrodes forming a high-frequency sensor for measuring the capacitance change induced by the particle in the liquid channel. The technique combined both of these measurements to extract the dielectric permittivity of the particle.

Abstract: The present invention relates to a device wherein fluid or air-induced instability is converted into a flow sensing mechanism by building a CPW (Coplanar Wave Guide) resonator. Depending on the flow rate, periodic transitions between two bistable states emerge. Owing to the dependence of the transition period and the flow rate, the use of this effect for on-chip flow rate sensing is achieved with this invention. Moreover, the present invention ensures a flow rate sensor to be used in the ventilation machines for the treatment of the COVID-19 pandemic.

Abstract: The present invention relates to a device wherein fluid or air-induced instability is converted into a flow sensing mechanism by building a CPW (Coplanar Wave Guide) resonator. Depending on the flow rate, periodic transitions between two bistable states emerge. Owing to the dependence of the transition period and the flow rate, the use of this effect for on-chip flow rate sensing is achieved with this invention. Moreover, the present invention ensures a flow rate sensor to be used in the ventilation machines for the treatment of the COVID-19 pandemic.

Abstract: The present invention relates to a device for determining the mass of a nanoparticle, virus or protein in a suspension or solution in a fluid. This device can be applied in particular to mass spectrometry for ionized species with high collection efficiency (i.e. low limit of detection). According to the present invention, an instrument comprises a first device for electrospraying the fluid to obtain a charged flux comprising at least the particle, a second device for determining the mass of the particle by a frequency measurement and a third device that is fabricated on the same chip with, and surrounding the second device to focus and guide the majority of the incoming charged particles including at least the particle by means of holding charge on itself to act as an electrostatic lens.

Abstract: A method and apparatus for sizing and imaging an analyte. The apparatus including an electromagnetic resonator, an input port, an output port, a microfluidic substrate, and a microfluidic channel having a first fluid port and a second fluid port wherein a first analyte species is manipulated and analyzed within the microfluidic channel. The electromagnetic resonator further including at least one ground plane for the electromagnetic resonator, and at least one signal path for the electromagnetic resonator.

Abstract: Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution.

Abstract: The spatial distribution of mass within an individual analyte can be imaged—in real time and with molecular-scale resolution—when it adsorbs onto a nanomechanical resonator. Each single-molecule adsorption event induces discrete, time-correlated perturbations to the modal frequencies of the device. By continuous monitoring of multiple vibrational modes, the spatial moments of mass distribution can be deduced for individual analytes, one-by-one, as they adsorb. This new method was validated for inertial imaging using both experimental multimode frequency-shift data and finite-element simulations—to analyze the inertial mass, position-of-adsorption, and the shape of individual analytes. Unlike conventional imaging, the spatial resolution of nanomechanical inertial imaging is not limited by wavelength-dependent diffraction phenomena; instead frequency fluctuation processes determine the ultimate attainable resolution. Advanced NEMS devices can provide atomic-scale resolution.

Abstract: Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution.

Abstract: The present invention relates to an apparatus for measuring a mass of a sample, using a nanoelectromechanical system (NEMS) arranged to receive the sample added onto a resonator of the NEMS and a microfluidic sample delivery and sample ionization system. The nanoelectromechanical system is located at an output of the ionization system. The nanoelectromechanical resonator system is highly sensitive and is capable of detecting masses in the single Dalton range.

Abstract: The present invention relates to an apparatus for measuring a mass of a sample, using a nanoelectromechanical system (NEMS) arranged to receive the sample added onto a resonator of the NEMS and a microfluidic sample delivery and sample ionization system. The nanoelectromechanical system is located at an output of the ionization system. The nanoelectromechanical resonator system is highly sensitive and is capable of detecting masses in the single Dalton range.