Patents by Inventor Mehran R. Hoonejani
Mehran R. Hoonejani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10379030Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.Type: GrantFiled: August 22, 2016Date of Patent: August 13, 2019Assignee: Owl biomedical, Inc.Inventors: John S Foster, Kevin E. Shields, Mehran R. Hoonejani, Mark A. Naivar, Yareeve Zemel
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Publication number: 20190143329Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which may be used to separate a target particle from non-target material in a sample stream. In order to improve the sorter speed, accuracy or yield, the particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the sample inlet channel. The particle manipulation device may have two separate sort output channels, wherein the sort channel used depends on the characteristics of the sort pulse delivered to the micromechanical particle manipulation device. Because of the improved focusing and pulse details, a droplet may be formed which contains a single particle, which may also be barcoded with an identifiable signature bead.Type: ApplicationFiled: January 4, 2019Publication date: May 16, 2019Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Kevin E. SHIELDS, Mehran R. HOONEJANI
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Publication number: 20180154361Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has a sample inlet channel, output channels, and a movable member formed on a substrate. The device may be used to separate a target particle from non-target material in a sample stream. In order to improve the sorter speed, accuracy or yield, the particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the sample inlet channel. The device may be manufactured using three or more substrates in a wafer stack, and each device may be singulated from the wafer stack using submerged trenches in the middle substrate.Type: ApplicationFiled: January 17, 2018Publication date: June 7, 2018Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Kevin E. SHIELDS, Mehran R. Hoonejani, Adam G. Swanson
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Publication number: 20170312749Abstract: A particle manipulation system uses a spiral focusing channel to focus particles into a distribution near the centerline of the flow. The spiral focusing channel may have first portion and a second portion, wherein the first portion has a uniform cross section and curves in an arc of at least about 180 degrees, and the second portion has undulating sidewalls resulting in a varying cross section. The first portion may focus the particles substantially in a plane, and the second portion may focus the particles in a dimension orthogonal to the plane.Type: ApplicationFiled: July 20, 2017Publication date: November 2, 2017Inventors: Daryl W. GRUMMITT, Mehran R. Hoonejani
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Publication number: 20170113222Abstract: A particle manipulation system uses a spiral focusing channel to focus particles into a distribution near the centerline of the flow. The spiral focusing channel may have first portion and a second portion, wherein the first portion has a uniform cross section and curves in an arc of at least about 180 degrees, and the second portion has undulating sidewalls resulting in a varying cross section. The first portion may focus the particles substantially in a plane, and the second portion may focus the particles in a dimension orthogonal to the plane.Type: ApplicationFiled: October 22, 2015Publication date: April 27, 2017Inventors: Daryl W. Grummitt, Mehran R. Hoonejani
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Publication number: 20160377525Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.Type: ApplicationFiled: August 22, 2016Publication date: December 29, 2016Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Kevin E. Shields, Mehran R. Hoonejani, Mark A. NAIVAR, Yareeve ZEMEL
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Publication number: 20160263575Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. The target particle may be, for example, a stem cell, zygote, a cancer cell, a T-cell, a component of blood, bacteria or DNA sample, for example. The particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the inlet channel.Type: ApplicationFiled: May 20, 2016Publication date: September 15, 2016Applicant: Owl biomedical, Inc.Inventors: John S. FOSTER, Stefan MILTENYI, Kamala R. Qalandar, Kevin E. Shields, Kimberly L. Turner, Mehran R. Hoonejani
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Patent number: 9404838Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. The target particle may be, for example, a stem cell, zygote, a cancer cell, a T-cell, a component of blood, bacteria or DNA sample, for example. The particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the inlet channel.Type: GrantFiled: October 1, 2013Date of Patent: August 2, 2016Assignee: Owl biomedical, Inc.Inventors: John S Foster, Nicholas C. Martinez, Stefan Miltenyi, Kamala R. Qalandar, Kevin E. Shields, Kimberly L. Turner, Mehran R. Hoonejani
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Publication number: 20150226657Abstract: A system and a method are described for separating particles suspended in a fluid stream according to their weight, size or density, based on their viscoelastic interaction with a suspending fluid. The system may include a particle manipulation stage for manipulating the particles in the sample fluid, an input channel for inputting a sample fluid containing target particles and non-target material, a viscoelastic region that separates particles according to their viscoelastic behavior in the sample fluid upstream of the particle manipulation stage and at least one pickoff channel that removes a subset of the separated particles.Type: ApplicationFiled: February 12, 2015Publication date: August 13, 2015Inventors: John S. Foster, John Francis Dunne, Daryl W. GRUMMITT, Mehran R. Hoonejani
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Publication number: 20150093810Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device, which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. The target particle may be, for example, a stern cell, zygote, a cancer cell, a component of blood, bacteria or DNA sample, for example. The particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the inlet channel.Type: ApplicationFiled: October 1, 2013Publication date: April 2, 2015Applicant: Owl biomedical, Inc.Inventors: John S. Foster, Nicholas C. Martinez, Stefan Miltenyi, Kamala R. Qalandar, Kevin E. Shields, Kimberly L. Turner, Mehran R. Hoonejani