Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of formula (I): wherein R1, R2, R3, R4 and R5 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.

Abstract: A system, method, device, and storage medium for managing device power consumption related to the field of Ethernet power supply. The system for includes a power supply mode monitoring module to monitor a power supply mode of power sourcing equipment in real time; a PoE power-saving strategy configuration module to display available power consumption and real-time power consumption data of a powered device and receiving an adjustment operation instruction; and a PoE power consumption estimation module configured to acquire a power consumption limit of the powered device, and estimate the real-time power consumption data and the available power consumption according to an adjustment target corresponding to the adjustment operation instruction provided from the PoE power-saving strategy configuration module, so as to adjust device functions of the powered device.

Abstract: An electrical connector assembly includes an electrical plug connector and an electrical receptacle connector. The electrical plug connector includes plug fixation members. The electrical receptacle connector includes receptacle fixation members. Through the engagement between the plug fixation member and the receptacle fixation member, upon using the electrical connector assembly, the electrical plug connector can be ensured not to detach from the electrical receptacle connector. Moreover, with simple operations of the plug fixation member and the receptacle fixation member, the electrical plug connector can be detached from the electrical receptacle connector smoothly.

Abstract: A board-to-board connector assembly includes: a plug connector having: a second body having a second slot and a second sidewall; and third metal members; and a socket connector having: a first body having an island, a first slot, and a first sidewall; and first and second metal members. The first metal members are disposed in the first body and extend from a bottom of the first sidewall to the island through the first slot. The second metal members are disposed in the first body, and straddles and covers a portion of the first sidewall. The third metal members are disposed in the second body, and straddle and cover a portion of the second sidewall. When the connectors are mated, the second sidewall is inserted into the first slot, the island is inserted into the second slot, and the third metal members are pressed against the first and second metal members.

Abstract: A biaxially-oriented film comprising a polyethylene having (A) a melt flow index of 1.0 g/10 min or more, (B) a density of 0.90 g/cm3 to less than 0.940 g/cm3, (C) a g?LCB of greater than 0.8, (D) ratio of comonomer content at Mz to comonomer content at Mw is greater than 1.0, (E) ratio of comonomer content at Mn to comonomer content at Mw is greater than 1.0, and (F) a ratio of the g?LCB to the g?zave is greater than 1.0, and where the film has a 1% secant in the transverse direction of 70,000 psi or more and Dart Drop of 350 g/mil or more.

Abstract: This invention relates to an oriented polyethylene film comprising polyethylene having: (A) a melt flow index of 1.0 g/10 min or more, (B) a density of 0.90 g/cm3 to less than 0.940 g/cm3, (C) a g?LCB of greater than 0.8, (D) ratio of comonomer content at Mz to comonomer content at Mw is greater than 1.0, (E) ratio of comonomer content at Mn to comonomer content at Mw is greater than 1.0, and (F) a ratio of the g?LCB to the g?Zave is greater than 1.0, where the film has a 1% secant in the transverse direction of 70,000 psi or more and Dart Drop of 350 g/mil or more.

Abstract: A board-to-board connector assembly includes a receptacle connector and a plug connector mated with each other. The receptacle connector includes a first body, first terminals and a pair of first metal members. The first body includes an island structure and a first receiving slot surrounding the island structure. The first terminals are respectively disposed on a first side and a second side of the first receiving slot, the first and second sides being opposite to each other. The first metal members are respectively disposed on a third side and a fourth side of the first receiving slot, the third and fourth sides being opposite to each other. The first metal member includes a base extending to a bottom on the third side or a bottom on the fourth side, and a pair of first elastic arms extending from the base and facing away from each other.

Abstract: An electrical connector assembly includes an electrical plug connector and an electrical receptacle connector corresponding to the electrical plug connector. The electrical plug connector includes a plug insulated housing as well as plug terminals and buckling portions on the plug insulated housing. The electrical receptacle connector includes a receptacle insulated housing as well as receptacle terminals and locking components on the receptacle insulated housing. The locking components at the two sides of the electrical receptacle connector are firmly buckled with the buckling portions at the two sides of the electrical plug connector. Therefore, during the use of the electrical connector assembly, the electrical plug connector can be prevented from detaching off the electrical receptacle connector.

Abstract: A first connector and a second connector are provided. The first connector includes an insulated body, first terminals, and fastening members. The first terminals and the fastening members are on the insulated body. The second connector includes an insulated base, second terminals, and positioning members. The second terminals and the positioning members are on the insulated base. The fastening members and the positioning members are enclosing structures covering the insulated body of the first connector and the insulated base of the second connector, respectively. The fastening members and the positioning members provide multi-point contacts.

Abstract: A first connector and a second connector are provided. The first connector includes an insulated body, first terminals, and fastening members. The first terminals and the fastening members are on the insulated body. The second connector includes an insulated base, second terminals, and positioning members. The fastening member has a first side plate and a second side plate formed as a stair structure for protecting the insulated body.

Abstract: The disclosure relates to a board-to-board connector including a body, multiple terminals and a pair of metal fittings. The body has an accommodating recess. The terminal is disposed on the body and a portion of each of the terminals extends to the accommodating recess. The metal fittings are disposed on the body and beside the accommodating recess. The terminals are located between metal fittings. Each of the metal fittings has at least one limiting portion that extends to the accommodating recess. The limiting portion leans against a corner of the accommodating recess so that the metal fittings and the body generate a two-dimensional limitation. A board-to-board connector assembly is also provided.

Abstract: It relates to a method for preparation of four kinds of 2?, 3?-cNMPs (2?, 3?-cAMP, 2?, 3?-cGMP, 2?, 3?-cCMP and 2?, 3?-cUMP), comprising steps of: (1) extract genomic DNA and amplify gene If3; (2) ligate If3 gene to expression plasmid to construct a recombinant vector, and transfer the recombinant vector to E. coli to obtain a recombinant strain. Cultivate the recombinant strain and collect the fermentation broth; (3) collect the cells form the fermentation broth and disrupt the cells, and then purify the recombinant protein IF3 from the cell extract by Ni2+-nitrilotriacetic acid resin. Incubate the recombinant protein IF3 solution at 0° C. for 3 days to release 2?, 3?-cNMPs from IF3, and centrifuge the solution; (4) Ultrafiltrate the supernatant to remove proteins, and prepare four kinds of 2?, 3?-cNMPs by high-performance liquid chromatographic (HPLC) on a C18 reversed-phase column.

Abstract: A first connector and a second connector are provided. The first connector includes an insulated body, first terminals, and fastening members. The first terminals and the fastening members are on the insulated body. The second connector includes an insulated base, second terminals, and positioning members. The fastening member has a first side plate and a second side plate formed as a stair structure for protecting the insulated body.

Abstract: A first connector and a second connector are provided. The first connector includes an insulated body, first terminals, and fastening members. The first terminals and the fastening members are on the insulated body. The second connector includes an insulated base, second terminals, and positioning members. The second terminals and the positioning members are on the insulated base. The fastening members and the positioning members are enclosing structures covering the insulated body of the first connector and the insulated base of the second connector, respectively. The fastening members and the positioning members provide multi-point contacts.