Patents by Inventor Mei Tan
Mei Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150423Abstract: Applications of different configurations of novel glucagon peptide 1 with fatty acid modification or nonmodification in the treatment of T2D or the pancreas protection are provided. The dimer of the present disclosure is formed by two identical cysteine-containing GLP-1 monomers through a disulfide bond. The H-like GLP-1 homodimer (disulfide bond is inside chains) showed remarkable increase in hypoglycemic duration without reducing specific activity. The GLP-1 dimer provided has an in-vivo effective duration of up to 19 days, which significantly prolonged compared with that of the positive control drug Liraglutide with 3 days of effective duration, or thereby greatly promoting the technical advancement in long-acting GLP-1 drugs and facilitating their clinical applications and business. Meanwhile the U-like homodimer (disulfide bond is at the C-terminus) does not affect blood glucose, but can obviously protect pancreatic exocrine cells such as acini and ducts, and improve pancreas function.Type: ApplicationFiled: November 9, 2020Publication date: May 9, 2024Applicant: Nanjing Finepeptide Biopharmaceutical Co.,LtdInventors: Song-Shan Tang, Qun Luo, Xu-Dong Zhang, Jing-Xuan TANG, Li Yang, Hong-Mei Tan
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Patent number: 11969703Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.Type: GrantFiled: September 16, 2021Date of Patent: April 30, 2024Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Robert Toso, Richard Spanggord, Mei Tan, Van Taiariol, Yekaterina Lin
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Publication number: 20230356223Abstract: An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.Type: ApplicationFiled: May 10, 2023Publication date: November 9, 2023Inventors: Shireen GOH, Shan Mei TAN
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Publication number: 20220238596Abstract: A micro light emitting diode display device includes a light-transmissive unit, a plurality of light emitting units and a plurality of converting units. The light-transmissive unit includes a protective layer which has opposite first and second surfaces. The light emitting units are arranged in an array on the second surface of the protective layer and each of the light emitting units includes first, second and third light emitting portions. The converting units are disposed on the first surface of the protective layer in positions corresponding to the light emitting units, respectively, and each of the converting units includes a reflecting feature, and first and second wavelength converting elements.Type: ApplicationFiled: January 6, 2022Publication date: July 28, 2022Applicant: MACROBLOCK, INC.Inventors: Chen-Yuan Kuo, Chen-Chi Yang, Mei-Tan Wang, Che-Wei Chang
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Publication number: 20220105490Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.Type: ApplicationFiled: September 16, 2021Publication date: April 7, 2022Inventors: Robert TOSO, Richard SPANGGORD, Mei TAN, Van TAIRIOL, Yekaterina LIN
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Patent number: 11123704Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.Type: GrantFiled: July 30, 2018Date of Patent: September 21, 2021Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Robert Toso, Richard Spanggord, Mei Tan, Van Tairiol, Yekaterina Lin
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Publication number: 20200066177Abstract: A multi-view display device includes a display screen component and an optical structure component. The display screen component includes a plurality of pixels, and each of the plurality of pixels includes a left sub-pixel and a right sub-pixel. The optical structure component is disposed at the display screen component. When light beams from the left sub-pixel and light beams from the right sub-pixel of the each of the plurality of pixels pass through the optical structure component, the optical structure component separates the light beams from the left sub-pixel and the light beams from the right sub-pixel so as to generate correspondingly a left image and a right image to reach the first pilot position and the second pilot position, respectively. In addition, a manipulation simulation device is also provided.Type: ApplicationFiled: August 23, 2019Publication date: February 27, 2020Inventors: JUNG-YU LI, SHIH-PU CHEN, YI-PING LIN, HONG-HUI HSU, MEI-TAN WANG
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Publication number: 20190275521Abstract: An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. In an embodiment, multiple inertial microfluidic devices are connected in sequence for combined inner wall and outer wall focusing. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.Type: ApplicationFiled: July 21, 2017Publication date: September 12, 2019Inventors: Shireen GOH, Shan Mei TAN
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Publication number: 20190039042Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.Type: ApplicationFiled: July 30, 2018Publication date: February 7, 2019Inventors: Robert Toso, Richard Spanggord, Mei Tan, Van Tairiol, Yekaterina Lin
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Publication number: 20180293667Abstract: The present application provides systems and methods for providing category-based user management notifications. The server provides at least one processor; and at least one memory including computer program code. The at least one memory and the computer program code are configured to, with the at least one processor, cause the server at least to: retrieve historical transaction data, the historical transaction data relating to a plurality of historical transactions that have been conducted using a plurality of accounts linked to an account identifier; classify the plurality of historical transactions into a plurality of categories of transactions based on a respective merchant identifier associated with each of the plurality of historical transactions; and provide a category-based user communication in regard to the historical transactions pertaining to one or more of the plurality of categories of transactions.Type: ApplicationFiled: April 5, 2018Publication date: October 11, 2018Inventors: Hui Luan Ariel Poh, Li Mei Tan, Siva Srikanth Sombhatla, Yi Feng Wang, Zunhua Wang
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Patent number: 9986943Abstract: Blood collection assemblies with safety features are disclosed. The assemblies have a housing for receiving a vacutainer, which has a septum that penetrates a sharp needle tip. The disclosed assemblies further have a shield for covering the other end of the needle following use to prevent accidental contact with the distal needle tip. The shield is spring loaded so that the spring force moves the shield over the needle. The shield can be secured or held in an initial position and allowed to move to cover the needle upon actuation or activation of an activator unit.Type: GrantFiled: June 20, 2014Date of Patent: June 5, 2018Assignee: B. Braun Melsungen AGInventors: Mohd Zairizal Bin Zakaria, Hwa Loon Chan, Teng Sun Teoh, Ai-Mei Tan
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Patent number: 9845493Abstract: The invention relates to cleavable chemistry in general, and in particular, to tunable fluorescence using cleavable linkers present in fluorochrome-quencher conjugates.Type: GrantFiled: April 21, 2014Date of Patent: December 19, 2017Assignee: Agency for Science, Technology and ResearchInventors: Sydney Brenner, Yin Nah Teo, Pee Mei Tan
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Publication number: 20170202498Abstract: A safety needle blood sampling device (100) is provided with a needle (108) having a multi-sampling Luer adaptor (MSLA) mounted over an end thereof. A housing (110) sized and shaped to receive a blood sampling vial is provided so that when a vacutainer is inserted, the MSLA is compressed to puncture the septum with one of the ends of the needle. A protective shield (104) is provided to cover the needle. A helical spring (106) is provided to move the protective shield over the needle in a used position. An activator (112) is further provided that is sized and shaped to activate the shield upon insertion of the vacutainer.Type: ApplicationFiled: May 27, 2015Publication date: July 20, 2017Applicant: B. Braun Melsungen AGInventors: Ai-Mei Tan, Hwa Loon Chan, Teng Sun Teoh, Mohd Zairizal bin Zakaria
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Publication number: 20160145280Abstract: The invention relates to cleavable chemistry in general, and in particular, to tunable fluorescence using cleavable linkers present in fluorochrome-quencher conjugates.Type: ApplicationFiled: April 21, 2014Publication date: May 26, 2016Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Sydney Brenner, Yin Nah Teo, Pee Mei Tan
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Publication number: 20150366496Abstract: Blood collection assemblies with safety features are disclosed. The assemblies have a housing for receiving a vacutainer, which has a septum that penetrates a sharp needle tip. The disclosed assemblies further have a shield for covering the other end of the needle following use to prevent accidental contact with the distal needle tip. The shield is spring loaded so that the spring force moves the shield over the needle. The shield can be secured or held in an initial position and allowed to move to cover the needle upon actuation or activation of an activator unit.Type: ApplicationFiled: June 20, 2014Publication date: December 24, 2015Inventors: Mohd Zairizal Bin Zakaria, Hwa Loon Chan, Teng Sun Teoh, Ai-Mei Tan
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Publication number: 20150129912Abstract: A light-emitting device package including a substrate, a packaging lens, a light-emitting unit and a plurality of optical microstructures is provided. The packaging lens and the light-emitting unit are disposed on the substrate and the packaging lens wraps the light-emitting unit. The packaging lens has a bottom surface and includes at least one platform. The at least one platform has a side surface and a platform surface. The bottom surface of the packaging lens is connected with the platform surface through the side surface. The platform surface faces away from the light-emitting unit and the bottom surface. The optical microstructures are located on the platform surface of the at least one platform.Type: ApplicationFiled: December 23, 2013Publication date: May 14, 2015Applicant: Industrial Technology Research InstituteInventors: Mei-Tan Wang, Jung-Min Hwang, Chun-Ting Lin, Chiun-Lern Fu
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Patent number: 9028131Abstract: The present invention discloses a high intensity ultrasonic treatment method and apparatus that is used in conjunction with an existing commercial dough or batter mixer to enhance the rheological, aeration and textural properties of the dough or batter. This change in properties is a result of the phenomenon of acoustic cavitation induced in the dough or batter by treatment with high intensity ultrasonic waves. The present invention discloses a mixing bowl (20) of an existing mixer system that is preloaded with dough or batter, the bowl (20) is located at the center of an ultrasonic bath tank (101) filled with a working fluid. The effect of ultra-sonic waves with power levels above 1 kW can be observed over the entire or partial mixing period of the dough or batter. The ultra-sonic waves of the present invention are generated by a plurality of ultrasonic wave generators (104A, 104B) and piezoelectric transducers (1) mounted on a stainless steel tank (101).Type: GrantFiled: October 5, 2011Date of Patent: May 12, 2015Assignee: Universiti Putra MalaysiaInventors: Ling Nyuk Chin, Ching Mei Tan, Nasrul Fikry Che Pa, Yus Aniza Yusof
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Publication number: 20130189407Abstract: The present invention discloses a high intensity ultrasonic treatment method and apparatus that is used in conjunction with an existing commercial dough or batter mixer to enhance the rheological, aeration and textural properties of the dough or batter. This change in properties is a result of the phenomenon of acoustic cavitation induced in the dough or batter by treatment with high intensity ultrasonic waves. The present invention discloses a mixing bowl (20) of an existing mixer system that is preloaded with dough or batter, the bowl (20) is located at the center of an ultrasonic bath tank (101) filled with a working fluid. The effect of ultra-sonic waves with power levels above 1 kW can be observed over the entire or partial mixing period of the dough or batter. The ultra-sonic waves of the present invention are generated by a plurality of ultrasonic wave generators (104A, 104B) and piezoelectric transducers (1) mounted on a stainless steel tank (101).Type: ApplicationFiled: October 5, 2011Publication date: July 25, 2013Applicant: Universiti Putra MalaysiaInventors: Ling Nyuk Chin, Ching Mei Tan, Nasrul Fikry Che Pa, Yus Aniza Yusof
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Publication number: 20060099146Abstract: It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at least one surfactant selected from: wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of R1, R2, R3 and R4, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 aryl, HS, COOH, NH2 or OH; R5 is COOH, NH2 or OH; with the proviso that n+m is <10; (b) an amino acid having the structure in (a), wherein X=1; Y=2; Z=1; W=1; R1, R2 and R4 are not present; R3 is NH2; and R5 is COOH; or (c) a peptide, wherein the peptide comprise at least one amino acid (b). Further, it is provided a NIR-sensitive nanoparticle complex(es) having biomolecule(s), for example drug(s), loaded on the surfactant(s).Type: ApplicationFiled: November 10, 2004Publication date: May 11, 2006Applicants: National University of Singapore, Massachussetts Institute of TechnologyInventors: Gan Chow, Mei Tan, Lei Ren, Jackie Ying