Patents by Inventor Mei-Wang Casey

Mei-Wang Casey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ICMT inhibitors
    Patent number: 9422238
    Abstract: The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CH2NR1R2 wherein R1 is H or C1 to C3 alkyl, R1 being optionally substituted with —OH, —SH, —NH2 or NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and R2 is C1 to C3 alkyl or (CH2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: August 23, 2016
    Assignee: National University of Singapore
    Inventors: Pondy Murugappan Ramanujulu, Tianming Yang, Mei-Wang Casey, Patrick J. Casey, Mei Lin Go
  • ICMT INHIBITORS
    Publication number: 20150218095
    Abstract: The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CH2NR1R2 wherein R1 is H or C1 to C3 alkyl, R1 being optionally substituted with —OH, —SH, —NH2 or NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and R2 is C1 to C3 alkyl or (CH2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group.
    Type: Application
    Filed: May 30, 2013
    Publication date: August 6, 2015
    Inventors: Pondy Murugappan Ramanujulu, Tianming Yang, Mei-Wang Casey, Patrick J. Casey, Mei Lin Go
  • Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
    Patent number: 8742100
    Abstract: The present invention generally relates to inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), in particularly to compounds that inhibit Icmt activity and pharmaceutical compositions thereof. The invention also relates to methods of disease treatment using the same.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: June 3, 2014
    Assignee: National University of Singapore
    Inventors: Jo Lene Leow, Mei-Wang Casey, Patrick J. Casey, Mei Lin Go, Kumar Gorla Suresh
  • SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY
    Publication number: 20120197014
    Abstract: The present invention generally relates to inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), in particularly to compounds that inhibit Icmt activity and pharmaceutical compositions thereof. The invention also relates to methods of disease treatment using the same.
    Type: Application
    Filed: July 30, 2010
    Publication date: August 2, 2012
    Inventors: Jo Lene Leow, Mei-Wang Casey, Patrick J. Casey, Mei Lin Go, Kumar Gorla Suresh