Patents by Inventor Mei Yang-Woytowitz
Mei Yang-Woytowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240018567Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: ApplicationFiled: February 6, 2023Publication date: January 18, 2024Inventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Patent number: 11845919Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.Type: GrantFiled: May 13, 2016Date of Patent: December 19, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Song Shi, Xiaofei Chang, James Y. Zhou, Michael A. Brasch
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Patent number: 11840719Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: July 13, 2020Date of Patent: December 12, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 11572579Abstract: Presented herein are methods, compositions, and kits for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: GrantFiled: July 2, 2020Date of Patent: February 7, 2023Assignee: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Publication number: 20210155969Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: ApplicationFiled: July 2, 2020Publication date: May 27, 2021Inventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Publication number: 20200340029Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: July 13, 2020Publication date: October 29, 2020Inventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 10767146Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: October 24, 2014Date of Patent: September 8, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Eric Ursprung, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 10704079Abstract: Presented herein are methods for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: GrantFiled: February 26, 2018Date of Patent: July 7, 2020Assignee: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Patent number: 10472662Abstract: Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in a dried form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an intracellular bacterial target) utilizing such solid supports. Further, presented herein are tablets as well as dry powders comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent), and methods of using such tablets and dry powders to detect the presence of an intracellular microorganism target (e.g., an intracellular bacterial target).Type: GrantFiled: December 1, 2017Date of Patent: November 12, 2019Assignee: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Publication number: 20190078043Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.Type: ApplicationFiled: May 13, 2016Publication date: March 14, 2019Applicant: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Song Shi, Xiaofei Chang, James Y. Zhou, Michael A. Brasch
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Publication number: 20180334701Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: ApplicationFiled: February 26, 2018Publication date: November 22, 2018Inventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Publication number: 20180087084Abstract: Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in a dried form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an intracellular bacterial target) utilizing such solid supports. Further, presented herein are tablets as well as dry powders comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent), and methods of using such tablets and dry powders to detect the presence of an intracellular microorganism target (e.g., an intracellular bacterial target).Type: ApplicationFiled: December 1, 2017Publication date: March 29, 2018Inventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Patent number: 9902989Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: GrantFiled: June 22, 2015Date of Patent: February 27, 2018Assignee: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Patent number: 9834807Abstract: Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in added form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an intracellular bacterial target) utilizing such solid supports. Further, presented herein are tablets as well as dry powders comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent), and methods of using such tablets and dry powders to detect the presence of an intracellular microorganism target (e.g., an intracellular bacterial target).Type: GrantFiled: October 20, 2009Date of Patent: December 5, 2017Assignee: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Publication number: 20160265022Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: October 24, 2014Publication date: September 15, 2016Applicant: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Publication number: 20160138076Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: ApplicationFiled: June 22, 2015Publication date: May 19, 2016Applicant: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Patent number: 9085794Abstract: Presented herein are kits for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The kits presented herein include kits that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: GrantFiled: February 27, 2013Date of Patent: July 21, 2015Assignee: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Publication number: 20140080164Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: ApplicationFiled: February 27, 2013Publication date: March 20, 2014Applicant: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Patent number: 8389234Abstract: Presented herein are kits for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The kits presented herein include kits that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: GrantFiled: November 30, 2011Date of Patent: March 5, 2013Assignee: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles
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Publication number: 20120077215Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.Type: ApplicationFiled: November 30, 2011Publication date: March 29, 2012Applicant: Becton, Dickinson and CompanyInventors: Mei Yang-Woytowitz, Charles Yu, Timothy Wiles