Abstract: Systems and methods for high availability distributed data storage are provided. In embodiments, a method includes: receiving, by a remote direct memory access (RDMA) switch operatively coupled to a computing device, a request to access a page of a database; determining, by the RDMA switch, a validation state of the page; determining, by the RDMA switch, a status of the page; updating, by the RDMA switch, the status of the page based on the validation state and the request; and reporting, by the RDMA switch, the validation state.

Abstract: A backlight module and a display device are disclosed. The backlight module includes a light board, and multiple light-emitting elements arranged at intervals on the light board. The backlight module further includes a diffusion plate arranged corresponding to the position of the light board and on the side of a light emitting surface of the light board. The diffusion plate includes: multiple blocking walls arranged at intervals on the side of the planar portion adjacent to the light board; and a planar portion arranged parallel to the light board. The blocking walls are perpendicular to the planar portion, and each blocking wall is arranged corresponding to the gap between two adjacent light-emitting elements. The height of the blocking wall is equal to the distance between the diffusion plate and the light board, and the lower part of the blocking wall adjacent to the light board is opaque.

Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

Abstract: A composition comprising an oat derived, salt precipitated ?-(1,3)-(1,4) glucan having a molecular weight from about 150 kDa to about 250 kDa, a Mw/Mn ratio of about 1.0 to about 1.25, and a D3/D4 ratio of about 1.5 to less than about 2.0.

Abstract: In some embodiments, the present disclosure provides stapled peptides and compositions thereof. In some embodiments, provided peptides can bind to and modulate functions of estrogen receptor.

Abstract: Systems and methods are disclosed for a numeric waiting bin for prescription fulfillment. A computing system may be used to receive bin configuration values corresponding to a plurality of physical bins for prescription storage. The bin configuration values may be used to assign serial identifiers to the plurality of bins. Prescriptions may be selectively assigned a bin serial identifier using a plurality of rules and the bin serial number may be used to locate the prescription when the prescription is requested, such as during pickup.

Abstract: A supervised similarity measure machine learning method, system, and computer program product that includes generating embeddings by training a supervised deep neural network (DNN) on a feature data to determine which nodes correspond to which clustered learning group of clustered learning groups, performing half-distributed learning by distributing data in a time-series database to the clustered learning groups, and evaluating, based on the embeddings, new tenant data in the clustered learning groups with an upward bow pose.

Abstract: A processor receives an optimization target for a first cluster in a distributed computing environment. A processor trains a neural network based on the optimization target. A processor generates a decision tree based on the neural network. A processor selects a workload executing in the first cluster of the distributed computing environment. A processor identifies a second cluster to relocate the workload. A processor determines a current optimization of the distributed computing environment based on the workload being retained in the first cluster. A processor determines a migration optimization of the distributed computing environment based on the workload being migrated to the second cluster. A processor, in response to the migration optimization improving the current optimization of the distributed computing environment, migrates the workload to the second cluster.

Abstract: The present invention comprises conjugates comprising a glucagon-like peptide 1 (GLP-1) fusion peptide coupled to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

Abstract: A computer-implemented method selects an access path for high cost and/or complex queries. The method includes building a classification model configured to identify a lowest cost access path. The method further includes receiving a query, where the query is configured to retrieve a set of data from a database. The method also includes generating an access map for the query, where the access map includes one or more potential access paths to execute the query. The method includes collecting, for the query, a set of data for each potential access path. The method further includes classifying, by the classification model, the query. The method also includes selecting a first access path of the one or more potential access paths and executing the query.

Abstract: A computer-implemented method includes: collecting, by a computing device, database activities and database structure information of a database; identifying, by the computing device, related columns in the database; determining, by the computing device, one or more data types for column transference of the identified related columns; generating, by the computing device, a super union column based on the column transference and the identified related columns; and updating, by the computing device, the database with the super union column.

Abstract: An embodiment includes generating a partition schema for a distributed database based on historical usage data indicative of usage of the distributed database, where the generating of the partition schema comprises determining a partition range of a partition of the partition schema. The embodiment also includes generating a node identifier for the partition using a hash function and a first weight value assigned to the partition. The embodiment also includes monitoring performance data indicative of a performance of the distributed database, the monitoring comprising detecting a failure of the performance to satisfy a performance threshold. The embodiment also includes initiating, responsive to detecting the failure, a redistribution procedure by changing the node identifier of the partition by replacing the first weight value with a second weight value.

Abstract: Query content-based data generation includes obtaining a query having an outer query and one or more subqueries, converting predicates of a subquery to be predicates of the outer query, and thereby obtain a transformed query, generate from the transformed query a query block having a list of predicate(s) selected from the transformed query, obtaining column information based on the list of predicate(s) and using the column information to select data for a dataset such that data records from the dataset are produced as results to executing the obtained query against the dataset.

Abstract: Disclosed are techniques for relational database locks based on columns. Database transactions may be targeted to specific columns of one or more records, instead of the entire row for those records, using primary keys. Column locks on specific keys are stored separately than column locks on ranges of keys, which are both checked when requesting a new column lock for either a single key or a range of keys. When a threshold number of columns for a given record, or range of records/keys, have been locked, the column locks for that record, or range of records, can be combined into a single row level lock to reduce resource costs for maintaining multiple concurrent locks.

Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

Abstract: A computer-implemented method that includes managing a buffer pool of pages into a ring sub-chain comprising pages linked in a ring, and a linear sub-chain comprising pages linked in a line from a header, and moving a page between the linear sub-chain and the ring sub-chain based on a moving schema evaluating a chain management characteristic.

Abstract: In a computer-implemented method for improving performance of a database, a processor receives batch jobs for a relational database. The batch jobs may include a first member with a first buffer pool, and a second member with a second buffer pool. The processor may also identify a first actual object and an isolation level for the batch jobs, generate related queries based on the first actual object and the isolation level, calculate a cost for the first member and the second member to run the batch jobs based on the related queries, and assign the batch jobs to the first member based on a lower calculated cost.

Abstract: A method of managing time series data workload requests includes receiving a workload job request from a user in a multi-tenant network, the request specifying a plurality of workloads, each workload including time series data configured to be stored in a time series database (TSDB), inputting workload information to a workload model that is specific to the user, and classifying each workload according to the workload model, the workload model configured to classify each workload based on a plurality of parameters, the plurality of parameters including at least a workload type and an amount of storage associated with each workload. The method also includes assigning each workload of the plurality of workloads into one or more workload groups based on the classifying, and executing each workload according to the workload type and the storage size.