Patents by Inventor Melaine Alpern

Melaine Alpern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing a topical fibrinogen complex
    Patent number: 5792835
    Abstract: A method for preparing a fibrinogen-containing composition derived from human plasma by separating a cryoprecipitate from the plasma, suspending the cryoprecipitate in a salt-containing buffer, treating the supernatant by affinity-chromatography on a lysine-bound solid matrix to allow plasminogen to adsorb thereon, collecting a fraction containing less than 10 .mu.g/ml plasminogen, and treating the fraction to reduce viral activity. The fibrinogen-containing composition recovered from this fraction is advantageous because it contains such a low amount of plasminogen that no addition of fibrinolysis inhibitor is needed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 11, 1998
    Assignee: Baxter International Inc.
    Inventors: Daphne C. Tse, Samia S. Mankarious, Shu Len Liu, William R. Thomas, Melaine Alpern, Stanley T. Enomoto, Cataline M. Garanchon
  • Topical fibrinogen complex
    Patent number: 5716645
    Abstract: A composition which, upon reacting with thrombin, functions as a fibrin sealant and is characterized as being free of detectable levels of lipid enveloped virus activity, free of prothrombin complex and active thrombin, and contains no protease inhibitors or other non-human proteins. Also, described is a method for producing the composition.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: February 10, 1998
    Assignee: Baxter International Inc.
    Inventors: Daphne C. Tse, Samia S. Mankarious, Shu Len Liu, William R. Thomas, Melaine Alpern, Stanley T. Enomoto, Cataline M. Garanchon
  • Compositions and method for the treatment or prophylaxis of sepsis or septic shock
    Patent number: 5093117
    Abstract: Pharmaceutical compositions useful for the treatment or prophylaxis of Gram-negative bacteremia or septic shock contain a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The compositions may further contain one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.A method for the treatment or prophylaxis of Gram-negative bacteremia or septic shock comprises administering, either together or separately, a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The method may optionally include administering one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: March 3, 1992
    Assignee: Baxter International Inc.
    Inventors: Joyce E. Lawrence, Michael J. Griffith, Melaine Alpern