Patents by Inventor Melanie S. Sanford
Melanie S. Sanford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11230517Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.Type: GrantFiled: September 9, 2020Date of Patent: January 25, 2022Assignees: The Regents of the University of Michigan, Dow Global Technologies LLCInventors: Melanie S. Sanford, Douglas Bland, Patrick S. Hanley, Megan A. Cismesia, Sydonie D. Schimler
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Patent number: 11059782Abstract: Disclosed is a fluorination method comprising providing a fluorinating reagent and a solvent to a reaction mixture; providing a compound having the formula Ar—X to the reaction mixture; wherein Ar is aryl, substituted aryl, heteroaryl or substituted heteroaryl, and X is Cl, Br, I or NO2, providing tetramethylammonium 2,6-dimethylphenolate to the reaction mixture; and reacting under conditions sufficient to provide a species having the formula Ar—F.Type: GrantFiled: July 13, 2017Date of Patent: July 13, 2021Assignees: Dow Global Technologies LLC, The Regents of the University of MichiganInventors: Melanie S. Sanford, Megan A. Cismesia, Patrick S. Hanley, Douglas Bland
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Patent number: 11056705Abstract: Organic anolyte materials for redox flow batteries and redox flow batteries containing organic anolyte materials are disclosed.Type: GrantFiled: June 8, 2016Date of Patent: July 6, 2021Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Melanie S. Sanford, Christo Slavov Sevov, Rachel Brooner, Etienne Chénard
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Patent number: 10913696Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.Type: GrantFiled: April 13, 2020Date of Patent: February 9, 2021Assignees: Dow Global Technologies LLC, The Regents of the University of MichiganInventors: Melanie S. Sanford, Douglas Bland, Patrick S. Hanley, Megan A. Cismesia, Sydonie D. Schimler
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Publication number: 20200407292Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.Type: ApplicationFiled: September 9, 2020Publication date: December 31, 2020Inventors: Melanie S. SANFORD, Douglas BLAND, Patrick S. HANLEY, Megan A. CISMESIA, Sydonie D. SCHIMLER
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Publication number: 20200239390Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing , a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar-OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar-OH to provide a fluorinated aryl species having the structure Ar-F.Type: ApplicationFiled: April 13, 2020Publication date: July 30, 2020Inventors: Melanie S. SANFORD, Douglas BLAND, Patrick S. HANLEY, Megan A. CISMESIA, Sydonie D. SCHIMLER
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Patent number: 10654776Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where A is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.Type: GrantFiled: May 2, 2017Date of Patent: May 19, 2020Assignee: Dow Global Technologies LLCInventors: Melanie S. Sanford, Douglas Bland, Patrick S. Hanley, Megan A. Cismesia, Sydonie D. Schimler
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Publication number: 20190292152Abstract: Disclosed is a f fluorination method comprising providing a fluorinating reagent and a solvent to a reaction mixture; providing a compound having the formula Ar—X to the reaction mixture; wherein, A is a aryl, substituted aryl, heteroaryl or substituted heteroaryl, and X is CI, Br, I or NO2, providing tetramethylammonium 2,6-dimethylphenolate to the reaction mixture; and reacting under conditions sufficient to provide a species having the formula Ar—F.Type: ApplicationFiled: July 13, 2017Publication date: September 26, 2019Inventors: Melanie S. SANFORD, Megan A. CISMESIA, Patrick S. HANLEY, Douglas BLAND
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Publication number: 20190202758Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where A is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.Type: ApplicationFiled: May 2, 2017Publication date: July 4, 2019Inventors: Melanie S. SANFORD, Douglas BLAND, Patrick S. HANLEY, Megan A. CISMESIA, Sydonie D. SCHIMLER
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Patent number: 10071943Abstract: Copper-catalyzed radiofluorination of iodonium salts, iodonium salts, and compounds obtained by copper-catalyzed radiofluorination of iodonium salts are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.Type: GrantFiled: April 10, 2015Date of Patent: September 11, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Peter J. H. Scott, Melanie S. Sanford, Naoko Ichiishi, Allen F. Brooks, Melissa Rodnick, Joseph J. Topczewski
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Publication number: 20180138539Abstract: Organic anolyte materials for redox flow batteries and redox flow batteries containing organic anolyte materials are disclosed.Type: ApplicationFiled: June 8, 2016Publication date: May 17, 2018Inventors: Melanie S. Sanford, Christo Slavov Sevov, Rachel Brooner, Etienne Chénard
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Publication number: 20170036980Abstract: Copper-catalyzed radiofluorination of iodonium salts, iodonium salts, and compounds obtained by copper-catalyzed radiofluorination of iodonium salts are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.Type: ApplicationFiled: April 10, 2015Publication date: February 9, 2017Inventors: Peter J. H. Scott, Melanie S. Sanford, Naoko Ichiishi, Allen F. Brooks, Melissa Rodick, Joseph J. Topczewski
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Publication number: 20160317682Abstract: Copper-catalyzed radiofluorination of aryl iodides using Ag18F, methods of preparing Ag18F, and compounds obtained by copper-catalyzed radiofluorination of aryl iodides using Ag18F are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.Type: ApplicationFiled: April 29, 2016Publication date: November 3, 2016Applicant: THE REGENTS OFTHE UNIVERSITY OF MICHIGANInventors: Peter J. H. Scott, Allen F. Brooks, Naoko Ichiishi, Melanie S. Sanford
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Patent number: 6818586Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula wherein: M is ruthenium or osmium; X and X1 are the same or different and are each independently an anionic ligand; L, L1′ and L2 are the same or different and are each independently a neutral electron donor ligand; and, R and R1 are each independently hydrogen or a substituent selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl and silyl.Type: GrantFiled: June 14, 2002Date of Patent: November 16, 2004Assignees: Cymetech, LLP, California Institute of TechnologyInventors: Robert H. Grubbs, Melanie S. Sanford, Jason L. Moore, Jennifer A. Love, Tina M. Trnka
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Patent number: 6759537Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula wherein: M is ruthenium or osmium; X and X1 are the same or different and are each independently an anionic ligand; L, L1′ and L2 are the same or different and are each independently a neutral electron donor ligand, wherein at least one L, L1′ and L2 is an N-heterocyclic carbene ligand; and, R and R1 are each independently hydrogen or a substituent selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl.Type: GrantFiled: December 14, 2001Date of Patent: July 6, 2004Assignees: California Institute of Technology, Cymetech, LLPInventors: Robert H. Grubbs, Jennifer A. Love, Melanie S. Sanford, Tina M. Trnka, Jason L. Moore
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Publication number: 20030069374Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same.Type: ApplicationFiled: June 14, 2002Publication date: April 10, 2003Applicant: California Institute of Technology and Cymetech, LLPInventors: Robert H. Grubbs, Melanie S. Sanford, Jason L. Moore, Jennifer A. Love, Tina M. Trnka
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Publication number: 20020177710Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same.Type: ApplicationFiled: December 14, 2001Publication date: November 28, 2002Applicant: California Institute Technology; Cymetech, LLCInventors: Robert H. Grubbs, Jennifer A. Love, Melanie S. Sanford, Tina M. Trnka, Jason L. Moore