Patents by Inventor Melanie Schultz

Melanie Schultz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine and piperazine derivatives as autotaxin inhibitors
    Patent number: 9452997
    Abstract: The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: September 27, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle
  • Benzonaphthyridinamines as autotaxin inhibitors
    Patent number: 9029387
    Abstract: The present invention relates to benzonaphthyridinamines of the formula (I) as autotaxin inhibitors and to the use thereof in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in which the inhibition, regulation and/or modulation of phosphodiesterase or lysophospholipase autotaxin plays a role, in particular of various types of cancer and autoimmune and inflammatory diseases.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: May 12, 2015
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Melanie Schultz, Kai Schiemann
  • Triazolopyrazine derivatives
    Patent number: 9023851
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Lars Burgdorf, Melanie Schultz, Carl Deutsch, Horacio Comas, Dominique Swinnen, Vincent Pomel, Pascale Gaillard, Brian Hodous
  • Furopyridine derivatives
    Patent number: 9006440
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis and/or systemic lupus.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: April 14, 2015
    Assignee: Merck Patent GmbH
    Inventors: Lars Burgdorf, Melanie Schultz, Tatjana Ross, Brian Hodous, Justin Potnick, Amanda E. Sutton, Bayard R. Huck
  • N-(benzimimdazol-2-yl)-cyclopropane carboxamides as lysophosphatidic acid antagonists
    Patent number: 8912202
    Abstract: The invention provides novel substituted cyclopropane carboxamide compounds according to Formula (I), their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
    Type: Grant
    Filed: July 7, 2012
    Date of Patent: December 16, 2014
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Melanie Schultz, Kai Schiemann
  • PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS
    Publication number: 20140343075
    Abstract: The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: July 30, 2014
    Publication date: November 20, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Kai SCHIEMANN, Melanie SCHULTZ, Wolfgang STAEHLE
  • Heterocyclic compounds as autotaxin inhibitors
    Patent number: 8841324
    Abstract: Compounds of the formula (I), in which Het, R, X, Y, R1 and p have the meanings indicated in claim 1, are autotaxin inhibitors and can be employed for the treatment of tumors.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: September 23, 2014
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Kai Schiemann, Melanie Schultz
  • Piperidine and piperazine derivatives as autotaxin inhibitors
    Patent number: 8822476
    Abstract: The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: September 2, 2014
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle
  • N-(Benzimimdazol-2-yl)-Cyclopropane Carboxamides as Lysophosphatidic Acid Antagonists
    Publication number: 20140228378
    Abstract: The invention provides novel substituted cyclopropane carboxamide compounds according to Formula (I), their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
    Type: Application
    Filed: July 7, 2012
    Publication date: August 14, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Melanie Schultz, Kai Schiemann
  • Piperidine and piperazine derivatives
    Patent number: 8791111
    Abstract: Compounds of the formula (I), in which R1, R2, R3, D, G, Q and W have the meanings indicated in Claim (1), can and be employed for the treatment of tumors.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: July 29, 2014
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Andree Blaukat, Ingo Kober
  • Piperidine and piperazine derivatives
    Patent number: 8754097
    Abstract: Compounds of the formula (I), in which R1, R2, R3, D, G, Q and W have the meanings indicated in claim (1), can and be employed for the treatment of tumors.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: June 17, 2014
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Andree Blaukat, Ingo Kober
  • Thiazole derivatives
    Patent number: 8557824
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, K, G, E and W
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: October 15, 2013
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Andree Blaukat, Ingo Kober, Wolfgang Staehle
  • Sulfoxide derivatives for the treatment of tumors
    Patent number: 8552001
    Abstract: Sulfoxide derivatives of the formula Ia to Im as described, and pharmaceutically usable salts, solvates, enantiomers, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for the treatment of tumors.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: October 8, 2013
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle
  • 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer
    Patent number: 8530650
    Abstract: The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: September 10, 2013
    Assignee: MERCK PATENT GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle, Ingo Kober, Dirk Wienke, Mireille Krier
  • FUROPYRIDINE DERIVATIVES
    Publication number: 20130225569
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis and/or systemic lupus
    Type: Application
    Filed: July 29, 2011
    Publication date: August 29, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Lars Burgdorf, Melanie Schultz, Tatjana Ross, Brian Hodous, Justin Potnick, Amanda E. Sutton, Bayard R. Huck
  • TRIAZOLOPYRAZINE DERIVATIVES
    Publication number: 20130225568
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
    Type: Application
    Filed: July 29, 2011
    Publication date: August 29, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Lars Burgdorf, Melanie Schultz, Carl Deutsch, Horacio Comas, Dominique Swinnen, Vincent Pomel, Pascale Gaillard, Brian Hodous
  • Autotaxin inhibitors
    Patent number: 8497283
    Abstract: The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 30, 2013
    Assignee: Merck Patent GmbH
    Inventors: Melanie Schultz, Kai Schiemann, Jr., Wolfgang Staehle
  • 7-azaindole derivatives as selective 11-?-hydroxysteroid dehydrogenase type 1 inhibitors
    Patent number: 8470849
    Abstract: The present invention relates to 7-azaindole derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11?-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: June 25, 2013
    Assignee: Merck Patent GmbH
    Inventors: Denis Carniato, Didier Roche, Sophie Hallakou-Bozec, Melanie Schultz
  • AUTOTAXIN INHIBITORS
    Publication number: 20130023556
    Abstract: The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 24, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Melanie SCHULTZ, Kai Schiemann, JR., Wolfgang Staehle
  • BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS
    Publication number: 20130012505
    Abstract: The present invention relates to benzonaphthyridinamines of the formula (I) as autotaxin inhibitors and to the use thereof in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in which the inhibition, regulation and/or modulation of phosphodiesterase or lysophospholipase autotaxin plays a role, in particular of various types of cancer and autoimmune and inflammatory diseases.
    Type: Application
    Filed: February 28, 2011
    Publication date: January 10, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Wolfgang Staehle, Melanie Schultz, Kai Schiemann