Patents by Inventor Melina R. Kibbe

Melina R. Kibbe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOMATERIALS FOR TARGETED TREATMENT OF PULMONARY TISSUE
    Publication number: 20230143731
    Abstract: Provided herein are compositions and methods for targeted drug delivery to treat pulmonary injury. In particular, provided herein are nanoscale delivery vehicles for: drugs that treat pulmonary injury. Also provided here in are methods of generating the nanoscale delivery vehicles and compositions thereof.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 11, 2023
    Inventors: Melina R. Kibbe, Kathleen Marulanda, Alexandra Mercel, Nick Tsihlis, Thomas Gregory Wyatt
  • NANOMATERIALS FOR TARGETED TREATMENT AND IMAGING OF ANEURYSMAL MICROENVIRONMENT
    Publication number: 20230072949
    Abstract: Provided herein are compositions and methods for targeted drug delivery to treat aneurysms. In particular, provided herein are nanoscale delivery vehicles for: drugs that inhibit the dilation of an aortic aneurysm, agents that detect abdominal aortic aneurysm by radiographic imaging, and drugs that treat abdominal aortic aneurysm. Also provided here in are methods of generating the nanoscale delivery vehicles and compositions thereof.
    Type: Application
    Filed: January 29, 2021
    Publication date: March 9, 2023
    Inventors: Melina R. Kibbe, Benjamin Ledford, Nick Tsihlis
  • DRUG DELIVERY VEHICLES FOR ATHEROSCLEROSIS NANOMEDICINE
    Publication number: 20200289416
    Abstract: Provided herein are peptide amphiphiles (PAs). In some embodiments, provided herein are targeting PAs comprising a PA backbone and a targeting moiety. In some embodiments, provided herein are therapeutic PAs comprising a PA backbone and a therapeutic agent. In some embodiments, the peptide amphiphiles are co-assembled into nanofibers. In some embodiments, the nanofibers may be used for the treatment of atherosclerosis or related disease.
    Type: Application
    Filed: February 17, 2020
    Publication date: September 17, 2020
    Inventors: Samuel I. Stupp, Melina R. Kibbe, Mark R. Karver, Erica B. Peters, Miranda So, Neel Anand Mansukhani, Mazen Albaghdadi
  • Tissue factor (TF)—targeted nanotherapy
    Patent number: 10738294
    Abstract: Provided herein are tissue factor (TF)-targeted nanofibers and methods of treating hemorrhage in a subject therewith. In particular, peptide amphiphiles (PAs) are provided that comprise a TF-targeting peptide sequence and self-assemble under aqueous conditions into PA nanofibers displaying the TF-targeting sequence on the exterior of the nanofiber.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: August 11, 2020
    Inventors: Melina R. Kibbe, Samuel I. Stupp
  • Triple balloon occlusion and infusion catheter for forming a stent in situ
    Patent number: 10398806
    Abstract: Disclosed are balloon catheters for forming liquid cast biodegradable arterial stents, typically, the balloon catheters include multiple balloons and multiple ports and include an element for promoting or initiating curing of a polymer solution via polymerization or cross-linking.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: September 3, 2019
    Assignee: Northwestern University
    Inventor: Melina R. Kibbe
  • TISSUE FACTOR (TF)-TARGETED NANOTHERAPY
    Publication number: 20180087039
    Abstract: Provided herein are tissue factor (TF)-targeted nanofibers and methods of treating hemorrhage in a subject therewith. In particular, peptide amphiphiles (PAs) are provided that comprise a TF-targeting peptide sequence and self-assemble under aqueous conditions into PA nanofibers displaying the TF-targeting sequence on the exterior of the nanofiber.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 29, 2018
    Inventors: Melina R. Kibbe, Samuel I. Stupp
  • Liquid cast biodegradable arterial stent
    Patent number: 9801738
    Abstract: Disclosed are liquid cast biodegradable arterial stents and methods for preparing liquid cast biodegradable arterial stents. The typically includes a biodegradable polymer and may include an agent for treating neointimal hyperplasia.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: October 31, 2017
    Assignee: Northwestern University
    Inventors: Melina R. Kibbe, Guillermo A. Ameer
  • Pharmaceutical compositions and methods for digesting atherosclerotic plaques
    Patent number: 9707281
    Abstract: Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: July 18, 2017
    Assignee: Northwestern University
    Inventors: Melina R. Kibbe, Guillermo A. Ameer, Vinit N. Varu
  • Targeted therapy for the prevention of restenosis in the cardiovascular system
    Patent number: 9517275
    Abstract: Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: December 13, 2016
    Assignee: Northwestern University
    Inventors: Melina R. Kibbe, Samuel I. Stupp, Tyson J. Moyer, Edward Moreira Bahnson
  • TARGETED THERAPY FOR THE PREVENTION OF RESTENOSIS IN THE CARDIOVASCULAR SYSTEM
    Publication number: 20150151002
    Abstract: Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia.
    Type: Application
    Filed: September 30, 2014
    Publication date: June 4, 2015
    Inventors: Melina R. Kibbe, Samuel I. Stupp, Tyson J. Moyer
  • Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques
    Publication number: 20140322190
    Abstract: Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
    Type: Application
    Filed: July 9, 2014
    Publication date: October 30, 2014
    Applicant: Northwestern University
    Inventors: Melina R. Kibbe, Guillermo A. Ameer, Vinit N. Varu
  • Liquid Cast Biodegradable Arterial Stent
    Publication number: 20130211500
    Abstract: Disclosed are liquid cast biodegradable arterial stents and methods for preparing liquid cast biodegradable arterial stents. The typically includes a biodegradable polymer and may include an agent for treating neointimal hyperplasia.
    Type: Application
    Filed: April 14, 2011
    Publication date: August 15, 2013
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Melina R. Kibbe, Guillermo A. Ameer
  • Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques
    Publication number: 20130195828
    Abstract: Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
    Type: Application
    Filed: April 14, 2011
    Publication date: August 1, 2013
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Melina R. Kibbe, Guillermo A. Ameer, Vinit N. Varu