Patents by Inventor Melissa M. Dixon

Melissa M. Dixon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant OPAA enzymes with increased catalytic efficiency on cyclosarin
    Patent number: 10538749
    Abstract: The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having two site mutations, methods of production, and methods of use to effectively degrade cylcosarin (GF) (cyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 21, 2020
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P Harvey, Melissa M Dixon, Mark A Guelta
  • Mutant OPAA enzyme with increased catalytic efficiency on organophosphorus compound GP
    Patent number: 10335465
    Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2?-dimethylcyclopentyl methylphosphonofluoridate).
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: July 2, 2019
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P Harvey, Melissa M Dixon, Mark A Guelta, Leslie R McMahon
  • Mutant organophosphorus acid anhydrolases and uses thereof
    Patent number: 10238904
    Abstract: Disclosed herein are non-wild-type organophosphorus acid anhydrolases having two site mutations, methods of production, and methods of use to effectively degrade toxic chemicals such as ((RS)-Propan-2-yl methylphosphonofluoridate) (Sarin) and other organophosphorus compounds.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: March 26, 2019
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Mark A Guelta, Melissa M. Dixon, Steven P Harvey
  • OPAA FL—a mutant enzyme with increased catalytic efficiency on organophosphorus compound GD
    Patent number: 9976130
    Abstract: This invention is directed toward a non-wild-type organophosphorus acid anhydrolase enzyme having two site mutations, method of production, and method of use to more effectively degrade toxic organophosphorus compounds and, in particular, toxic chemical GD (3,3-Dimethylbutan-2-ylmethylphosphonofluoridate), than the wild type organophosphorus acid anhydrolase.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: May 22, 2018
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Mark A Guelta, Melissa M. Dixon, Steven P. Harvey