Patents by Inventor Melissa M. Sprachman
Melissa M. Sprachman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230391819Abstract: Compositions and methods for optically-verified, sequence-controlled polymer synthesis are described.Type: ApplicationFiled: August 22, 2023Publication date: December 7, 2023Inventors: Andrew P. Magyar, Melissa M. Sprachman
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Patent number: 11773133Abstract: Compositions and methods for optically-verified, sequence-controlled polymer synthesis are described.Type: GrantFiled: January 5, 2018Date of Patent: October 3, 2023Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Andrew P. Magyar, Melissa M. Sprachman
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Patent number: 10975407Abstract: A composition for use in extending a molecular chain includes a carrier group and a payload group. The carrier group comprising a signaling group and a blocking group. A first bond bonds the payload group to the carrier group and a second bond bonds the signaling group to the blocking group. The first and second bonds are selectively cleavable such that the first bond is cleavable without cleaving the second bond. The payload group is to be attached to the molecular chain, while the blocking group is to block further attachments to the molecular chain once the payload group has been attached. The signaling group comprises a photon emitter that emits a signature photon in response to interrogation by an interrogatory photon. The carrier group transitions from a loaded state to an empty state upon cleavage of the first covalent bond.Type: GrantFiled: May 22, 2017Date of Patent: April 13, 2021Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Melissa M. Sprachman, Andrew P. Magyar, Kettner John Frederick Griswold, Jr.
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Publication number: 20200263152Abstract: Described herein are genetically engineered template-independent DNA polymerases, specifically terminal deoxynucleotidyl transferases, and methods of using these polymerases to control DNA synthesis by adding a single nucleotide (mononucleotide) at a time to the 3? end of a growing single-stranded DNA polynucleotide.Type: ApplicationFiled: May 22, 2018Publication date: August 20, 2020Inventors: Andrew P. Magyar, Peter Cavanagh, Miles Rogers, Kirsty A. McFarland, Melissa M. Sprachman, Amanda Nicole Billings-Siuti, Nicole E. Raustad
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Publication number: 20190354871Abstract: A parallelized chain-synthesizing technique includes capillary tubes, where each tube provides multiple locations or addresses where a specific arbitrary sequence for polymeric chains can be synthesized. An optical addressing system selectively delivers light to the locations to mediate or control reactions in the tubes.Type: ApplicationFiled: May 17, 2019Publication date: November 21, 2019Inventors: Kirsty A. McFarland, Andrew P. Magyar, Ian Ward Frank, Kenneth T. Kotz, Stacey Markovic, Haiyao Huang, Steven J. Byrnes, Gregg E. Favalora, Melissa M. Sprachman, Ryan A. Dubay, Emma Vargo, Peter Cavanagh, Erin Rosenberger
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Publication number: 20190323049Abstract: A composition for use in extending a molecular chain includes a carrier group and a payload group. The carrier group comprising a signaling group and a blocking group. A first bond bonds the payload group to the carrier group and a second bond bonds the signaling group to the blocking group. The first and second bonds are selectively cleavable such that the first bond is cleavable without cleaving the second bond. The payload group is to be attached to the molecular chain, while the blocking group is to block further attachments to the molecular chain once the payload group has been attached. The signaling group comprises a photon emitter that emits a signature photon in response to interrogation by an interrogatory photon. The carrier group transitions from a loaded state to an empty state upon cleavage of the first covalent bond.Type: ApplicationFiled: May 22, 2017Publication date: October 24, 2019Inventors: Melissa M. Sprachman, Andrew P. Magyar, Kettner John Frederick Griswold, Jr.
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Publication number: 20190322699Abstract: Compositions and methods for optically-verified, sequence-controlled polymer synthesis are described.Type: ApplicationFiled: January 5, 2018Publication date: October 24, 2019Inventors: Andrew P. Magyar, Melissa M. Sprachman
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Patent number: 9546144Abstract: A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy gType: GrantFiled: October 12, 2015Date of Patent: January 17, 2017Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Peter Wipf, Joel S. Greenberger, Michael W. Epperly, Melissa M. Sprachman, Julie Pamela Goff
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Publication number: 20160176836Abstract: A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy gType: ApplicationFiled: October 12, 2015Publication date: June 23, 2016Applicant: University of Pittsburgh - of the Commonwealth System of Higher EducationInventors: Peter Wipf, Joel S. Greenberger, Michael W. Epperly, Melissa M. Sprachman, Julie Pamela Goff
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Patent number: 9200035Abstract: A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy gType: GrantFiled: October 19, 2012Date of Patent: December 1, 2015Assignee: University of Pittsburgh—of the Commonwealth System of Higher EducationInventors: Peter Wipf, Joel S. Greenberger, Michael W. Epperly, Melissa M. Sprachman, Julie Pamela Goff
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Publication number: 20140256654Abstract: A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy gType: ApplicationFiled: October 19, 2012Publication date: September 11, 2014Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Peter Wipf, Joel S. Greenberger, Michael W. Epperly, Melissa M. Sprachman, Julie Pamela Goff