Abstract: Disclosed is a medical pad for exchanging thermal energy between a targeted temperature management (TTM) fluid and a patient. The pad includes a fluid channel extending between a fluid inlet and a fluid outlet, and a bottom channel wall that is disposed between the fluid and the patient during use of the pad. The wall is formed of a material having a thermal conductivity, and the wall includes elements embedded within the wall. The elements are formed of a material having a greater thermal conductivity than the wall material so that a composite thermal conductivity of the wall that is greater than the thermal conductivity of the wall material alone. The thermal energy exchange between the fluid and the patient is defined in accordance with the composite thermal conductivity. The pad can include channel shapes and features that enhance the heat transfer convection coefficient of the fluid within the channel.

Abstract: A sheath assembly for use with an endoscope and an endoscope that includes the sheath assembly. The sheath assembly can include an elongate tubular sheath configured to thread onto a shaft of the endoscope. The sheath can include a pliable segment at a distal end of the sheath, and a tensile filament extends along a circumference of the pliable segment. The tensile filament can form a cinching loop at a distal end of the pliable segment. The sheath can be displaceable along the endoscope between a retracted position and an extended position. The pliable segment can extend distally beyond a distal end of the endoscope to form a chamber, and proximal displacement of the tensile filament tightens the cinching loop to convert the chamber from an open configuration to a closed configuration.

Abstract: Disclosed herein is a system, apparatus and method directed to an expandable and conformable targeted temperature management (TTM) pad. The system, apparatus and method pertain to a medical pad for exchanging thermal energy between a TTM fluid and a patient. The pad includes an insulating layer, a fluid containing layer for containing the TTM fluid, and a patient contact surface. The fluid containing layer is configured for circulating the TTM fluid. The patient contact surface defines a first patient contact area to facilitate thermal energy exchange with the patient. One or more slits are arranged in at least the insulating layer of the pad to facilitate stretching the pad and conforming to a contour of a patient's anatomy. The stretching can expand the patient contact surface to a larger second patient contact area. The pad can further include a flexible fabric cover.

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Abstract: Methods and compositions for preparing dry formulations of Glucose Binding Proteins (GBPs) are disclosed. The GBPs may be stored as a dry formulation without significant loss of activity. After reconstitution, the GBPs may be used to determine the glucose concentration of a sample.