Patents by Inventor Menachem Rubinstein

Menachem Rubinstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF LEUKOTRIENE-MEDIATED ACTIVITY FOR TREATING SIDE EFFECTS OF STATIN THERAPY
    Publication number: 20180064682
    Abstract: The present invention relates to the alleviation of adverse side effects resulting from statin therapy. The present invention further relates to the use of an inhibitor of leukotriene C4 (LTC4) mediated activity for alleviating at least one side effects of statin therapy.
    Type: Application
    Filed: October 31, 2017
    Publication date: March 8, 2018
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Menachem RUBINSTEIN, Efrat DVASH-RIESENFELD
  • INHIBITORS OF LEUKOTRIENE-MEDIATED ACTIVITY FOR TREATING SIDE EFFECTS OF STATIN THERAPY
    Publication number: 20170172979
    Abstract: The present invention relates to the alleviation of adverse side effects resulting from statin therapy. The present invention further relates to the use of an inhibitor of leukotriene C4 (LTC4) mediated activity for alleviating at least one side effects of statin therapy.
    Type: Application
    Filed: February 18, 2015
    Publication date: June 22, 2017
    Inventors: Menachem RUBINSTEIN, Efrat DVASH-RIESENFELD
  • RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
    Publication number: 20160152991
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 2, 2016
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yitzhak PILPEL, Tamir TULLER, Sivan NAVON, Menachem RUBINSTEIN
  • Recombinant protein production in heterologous systems
    Patent number: 9267142
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: February 23, 2016
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yitzhak Pilpel, Tamir Tuller, Sivan Navon, Menachem Rubinstein
  • Method for screening inhibitors of interleukin-32 (IL-32)
    Patent number: 9045559
    Abstract: The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: June 2, 2015
    Assignees: Yeda Research and Development Co. Ltd, The Regents of the University of Colorado
    Inventors: Daniela Novick, Menachem Rubinstein, Charles A. Dinarello, Soo-Hyun Kim
  • Glycan modified soluble receptors and binding protein and their use
    Patent number: 8871723
    Abstract: An invention relates to a glycan-modified soluble receptor or binding protein of a cytokine, growth factor, lipoprotein or oxidized lipoprotein, modified to carry a terminal Gal, GlcNAc or GalNAc.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: October 28, 2014
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Menachem Rubinstein, Ariel Werman, Ben Alkahe
  • Antibodies against interleukin-18 binding protein, their preparation and use
    Patent number: 8436148
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: May 7, 2013
    Inventors: Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Daniela Novick
  • RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
    Publication number: 20120329091
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Application
    Filed: January 25, 2011
    Publication date: December 27, 2012
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Yitzhak Pilpel, Tamir Tuller, Sivan Navon, Menachem Rubinstein
  • Method for inhibiting release of hepatitis B virus from liver cells
    Patent number: 8293706
    Abstract: The invention relates to the use of the souluble LDL receptor (sLDLR) in viral hepatitis.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: October 23, 2012
    Inventors: Menachem Rubinstein, Ariel Werman, Ben Alkahe
  • Catecholamine receptor modulation
    Patent number: 8241903
    Abstract: The invention relates to receptors of catecholamines and their role in stem cell development and function.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: August 14, 2012
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Tsvee Lapidot, Asaf Spiegel, Menachem Rubinstein, Alexander Kalinkovich, Shoham Shivtiel
  • Isolated cDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA
    Patent number: 8138323
    Abstract: An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising antibodies against a polypeptide that is a fragment of TNF Binding Protein II. The DNA may be used to produce replicable expression vehicles and prokaryotic or eukaryotic expression host cells. Such host cells may be used to produce polypeptides encoded by such DNA molecules.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: March 20, 2012
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Hartmut Engelmann, Dan Aderka, Daniela Novick, Menachem Rubinstein
  • METHODS OF TREATING/PREVENTING INFLAMMATION USING COMBINATION OF IL-1 ANTAGONIST AND IL-18 BINDING PROTEIN
    Publication number: 20110177065
    Abstract: The invention relates to the combined use of an IL-1 antagonist/inhibitor and IL-18 binding protein in inflammatory diseases.
    Type: Application
    Filed: February 15, 2011
    Publication date: July 21, 2011
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Menachem Rubinstein, Daniela Novick, Vladimir Hurgin
  • IL-32 MODULATORS
    Publication number: 20110044999
    Abstract: The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use.
    Type: Application
    Filed: October 8, 2010
    Publication date: February 24, 2011
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: DANIELA NOVICK, MENACHEM RUBINSTEIN, CHARLES A. DINARELLO, SOO-HYUN KIM
  • Promoter to IL-18BP, its preparation and use
    Patent number: 7868154
    Abstract: The present invention relates to the promoter of interleukin-18 binding protein (IL-18BP), to its preparation and use.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: January 11, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Menachem Rubinstein, Daniela Novick, Vladimir Hurgin
  • SLDLR IN VIRAL HEPATITIS
    Publication number: 20100279928
    Abstract: The invention relates to the use of the souluble LDL receptor (sLDLR) in viral hepatitis.
    Type: Application
    Filed: January 7, 2009
    Publication date: November 4, 2010
    Inventor: Menachem RUBINSTEIN
  • INTERLEUKIN-18 BINDING PROTEINS, THEIR PREPARATION AND USE FOR THE TREATMENT OF SEPSIS
    Publication number: 20100254941
    Abstract: The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.
    Type: Application
    Filed: March 1, 2010
    Publication date: October 7, 2010
    Applicant: Yeda Research Institute and Development Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Giamila Fantuzzi, Leonid L. Reznikov, Boris Schwartsburd
  • Interleukin-18 binding proteins, their preparation and use
    Patent number: 7799541
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vecotors useful for their expression in humans and other mammals, antibodies against them are also provided.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: September 21, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim
  • Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
    Patent number: 7704944
    Abstract: The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: April 27, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Giamila Fantuzzi, Leonid L. Reznikov, Boris Schwartsburd
  • Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
    Patent number: 7696154
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding them. DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided. Therapeutic uses of IL-18 binding proteins and further inhibitors of IL-18 are also provided according to the invention.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: April 13, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Yolande Chvatchko, Christine Plater-Zyberk
  • GLYCAN MODIFIED SOLUBLE RECEPTORS AND BINDING PROTEIN AND THEIR USE
    Publication number: 20100087363
    Abstract: An invention relates to a glycan-modified soluble receptor or binding protein of a cytokine, growth factor, lipoprotein or oxidized lipoprotein, modified to carry a terminal Gal, GlcNAc or GalNAc.
    Type: Application
    Filed: April 30, 2008
    Publication date: April 8, 2010
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Menachem Rubinstein, Ariel Werman, Ben Alkahe