Patents by Inventor Mengchao Fu

Mengchao Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240141347
    Abstract: An RNA delivery system for the treatment of Huntington's disease. The system comprises a viral vector, the viral vector carries RNA fragments capable of treating Huntington's disease, the viral vector is capable of enrichment in organ tissues of a host and endogenously and spontaneously forming a complex containing the RNA fragments capable of treating Huntington's disease in the organ tissues of the host, and the complex can deliver the RNA fragments into a target tissue to treat Huntington's disease. The safety and reliability of the RNA delivery system for the treatment of Huntington's disease have been fully verified. The system has good medicinal properties, strong versatility, and has economic benefits and application prospects.
    Type: Application
    Filed: September 28, 2023
    Publication date: May 2, 2024
    Inventors: Chenyu ZHANG, Xi CHEN, Zheng FU, Jing LI, Xiang ZHANG, Xinyan ZHOU, Li ZHANG, Mengchao YU, Hongyuan GUO
  • Publication number: 20240141361
    Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.
    Type: Application
    Filed: September 28, 2023
    Publication date: May 2, 2024
    Inventors: Chenyu Zhang, Xi Chen, Zheng Fu, Jing Li, Xiang Zhang, Xinyan Zhou, Li Zhang, Mengchao Yu, Hongyuan Guo
  • Publication number: 20240141344
    Abstract: Provided are an RNA plasmid delivery system and an application thereof. The RNA plasmid delivery system comprises a plasmid carrying an RNA fragment required to be delivered; the plasmid can be enriched in an organ tissue of a host, and spontaneously forms an exosome containing the RNA fragment in the organ tissue of the host, and therefore can enter and be combined with a target tissue to deliver the RNA fragment into the target tissue. The RNA delivery system is safe, reliable, good in druggability, and strong in universality.
    Type: Application
    Filed: September 28, 2023
    Publication date: May 2, 2024
    Inventors: Chenyu Zhang, Xi Chen, Zheng Fu, Jing Li, Xiang Zhang, Xinyan Zhou, Li Zhang, Mengchao Yu, Hongyuan Guo
  • Publication number: 20240141380
    Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.
    Type: Application
    Filed: September 28, 2023
    Publication date: May 2, 2024
    Inventors: Chenyu Zhang, Xi Chen, Zheng Fu, Jing Li, Xiang Zhang, Xinyan Zhou, Li Zhang, Mengchao Yu, Hongyuan Guo
  • Patent number: 9969289
    Abstract: A system and method for monitoring coordination/control of a multi-output integrated charger for electric automobiles, comprising a voltage/current demand collection module, an optimal-policy design module, and a policy execution module. The voltage/current demand collection module transmits demand information to the optimal-policy design module; the optimal-policy design module provides policy design results to the policy execution module; the policy execution module feeds back execution results to the optimal-policy design module; and, the optimal-policy design module feeds back the results to the voltage/current demand collection module. By means of real-time selection of an optimal power output policy, the present invention solves the safety, timeliness, and versatility issues concerning demand for power, voltage, and current during the charging process.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 15, 2018
    Assignee: SHANDONG LUNENG INTELLIGENCE TECHNOLOGY CO., LTD
    Inventors: Shiyou Mu, Antai Zuo, Juntian He, Xiangjun Meng, Chongguang Fu, Mengchao Fu, Yong Yang, Song Chen, Zonghui Zhang
  • Patent number: 9969286
    Abstract: A smart, integrated charging device for electric vehicles is provided. The alternating current input module is connected to an electricity metering module via an alternating current input switch. The charging module is connected to the electricity metering module via a module alternating current switch and an alternating current bus, and is connected to an output monitoring module via a direct current bus. The output monitoring module is connected to the monitoring and general control module (13). The direct current output module is connected to the output monitoring module (4) via a direct current output switch. The lightning protection module is connected to the direct current bus. The charging module utilizes smart power combination and multiple output coordination to enable output with current sharing and the automatic balance control technology.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 15, 2018
    Assignee: SHANDONG LUNENG INTELLIGENCE TECHNOLOGY CO., LTD
    Inventors: Bin Jiang, Mengchao Fu, Juntian He, Song Chen, Antai Zuo, Xiangjun Meng, Shiyou Mu, Yong Yang, Yong Hu, Yabo Zhao, Hailong Zhang, Tao Cao
  • Publication number: 20160221464
    Abstract: A system and method for monitoring coordination/control of a multi-output integrated charger for electric automobiles, comprising a voltage/current demand collection module, an optimal-policy design module, and a policy execution module. The voltage/current demand collection module transmits demand information to the optimal-policy design module; the optimal-policy design module provides policy design results to the policy execution module; the policy execution module feeds back execution results to the optimal-policy design module; and, the optimal-policy design module feeds back the results to the voltage/current demand collection module. By means of real-time selection of an optimal power output policy, the present invention solves the safety, timeliness, and versatility issues concerning demand for power, voltage, and current during the charging process.
    Type: Application
    Filed: October 21, 2014
    Publication date: August 4, 2016
    Applicant: SHANDONG LUNENG INTELLIGENCE TECHNOLOGY CO., LTD
    Inventors: Shiyou Mu, Antai Zuo, Juntian He, Xiangjun Meng, Chongguang Fu, Mengchao Fu, Yong Yang, Song Chen, Zonghui Zhang
  • Publication number: 20160193933
    Abstract: A smart, integrated charging device for electric vehicles is provided. The alternating current input module is connected to an electricity metering module via an alternating current input switch. The charging module is connected to the electricity metering module via a module alternating current switch and an alternating current bus, and is connected to an output monitoring module via a direct current bus. The output monitoring module is connected to the monitoring and general control module. The direct current output module is connected to the output monitoring module via a direct current output switch. The lightning protection module is connected to the direct current bus. The charging module utilizes smart power combination and multiple output coordination to enable output with current sharing and the automatic balance control technology.
    Type: Application
    Filed: October 21, 2014
    Publication date: July 7, 2016
    Applicant: SHANDONG LUNENG INTELLIGENCE TECHNOLOGY CO., LTD
    Inventors: Bin Jiang, Mengchao Fu, Juntian He, Song Chen, Antai Zuo, Xiangjun Meng, Shiyou Mu, Yong Yang, Yong Hu, Yabo Zhao, Hailong Zhang, Tao Cao