Abstract: The present invention generally pertains to methods of identifying and characterizing host cell proteins. In particular, the present invention pertains to the use of size exclusion chromatography in non-denaturing or denaturing conditions to enrich a sample for host cell proteins and characterize the binding of host cell proteins to a protein of interest.

Abstract: A pulse detonation combustion system includes: an inlet pipe; an intake cone disposed in the inlet pipe, having an end provided with a pneumatic valve, and including an atomizing air transfer tube, a fuel transfer tube, and a conical swirl nozzle connected to the atomizing air transfer tube and the fuel transfer tube; an atomizing air intake tube connected with the atomizing air transfer tube; a fuel supply tube connected with the fuel transfer tube; a pulse detonation combustion chamber located downstream of and communicated to the inlet pipe, and provided with a spark plug mounting seat for mounting a spark plug; a gas energy distribution adjustment device located downstream of and communicated to the pulse detonation combustion chamber; and a transition section located downstream of and communicated to the gas energy distribution adjustment device.

Abstract: A gas turbine power generation device includes: an inlet pipe (1), a compressor (2), an air storage compartment (3), a compressor rotor (4), a compressor gear shift (6), a compressor exhaust pipeline (8), a combustion chamber intake pipeline (10), a combustion chamber intake cone (11), a combustion chamber pneumatic valve (14), a spark plug (19), a combustion chamber (21), a Tesla turbine (22), a gas collection compartment (27), an outlet pipe (28), a turbine rotor (30), a generator gear shift (32) and a generator (33).

Abstract: Methods for characterizing host-cell proteins in a sample matrix are provided.

Abstract: A pulse detonation combustion system includes: an inlet pipe; an intake cone disposed in the inlet pipe, having an end provided with a pneumatic valve, and including an atomizing air transfer tube, a fuel transfer tube, and a conical swirl nozzle connected to the atomizing air transfer tube and the fuel transfer tube; an atomizing air intake tube connected with the atomizing air transfer tube; a fuel supply tube connected with the fuel transfer tube; a pulse detonation combustion chamber located downstream of and communicated to the inlet pipe, and provided with a spark plug mounting seat for mounting a spark plug; a gas energy distribution adjustment device located downstream of and communicated to the pulse detonation combustion chamber; and a transition section located downstream of and communicated to the gas energy distribution adjustment device.

Abstract: A gas turbine power generation device includes: an inlet pipe (1), a compressor (2), an air storage compartment (3), a compressor rotor (4), a compressor gear shift (6), a compressor exhaust pipeline (8), a combustion chamber intake pipeline (10), a combustion chamber intake cone (11), a combustion chamber pneumatic valve (14), a spark plug (19), a combustion chamber (21), a Tesla turbine (22), a gas collection compartment (27), an outlet pipe (28), a turbine rotor (30), a generator gear shift (32) and a generator (33).

Abstract: A dry low NOX staged combustion system includes a fuel nozzle and a combustion compartment. The fuel nozzle includes a purge gas tube, a diffusion combustion fuel tube, an isolation gas tube, a premixed combustion fuel tube, a premixed combustion air tube. The purge gas tube is configured to feed a purge gas. The diffusion combustion fuel tube is fitted over the purge gas tube, and having an end provided with a diffusion combustion fuel swirler. The isolation gas tube is fitted over the diffusion combustion fuel tube. The premixed combustion fuel tube is fitted over the isolation gas tube. The premixed combustion air tube is fitted over the premixed combustion fuel tube. The combustion compartment is located downstream of the fuel nozzle.

Abstract: The present disclosure generally pertains to methods of identifying and quantitating host cell proteins (HCPs) in therapeutic protein development. In particular, the present invention generally pertains to methods of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for unbiased identification and sensitive quantitation of HCPs in therapeutic protein development.