Patents by Inventor Merilyn Joy Sleigh

Merilyn Joy Sleigh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulated autocrine growth of mammalian cells
    Patent number: 6797515
    Abstract: Methods of production of desired recombinant proteins, polypeptides and peptides are disclosed which utilize mammalian host cells engineered for autonomous and regulated growth in low cost protein/serum-free culture media. Preferred host cells express insulin or an insulin-like growth factor, and/or transferrin and are engineered so that addition of an inducer (e.g., ZnCl2+CdCl2) halts growth and simultaneously induces the expression of the desired recombinant protein, polypeptide or peptide.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: September 28, 2004
    Assignees: Unisearch Limited, Commonwealth Scientific and Industrial Research Organisation
    Inventors: Sybille Marie Hunt, Peter Philip Gray, Merilyn Joy Sleigh
  • Regulated autocrine growth of mammalian cells
    Publication number: 20020102650
    Abstract: Methods of production of desired recombinant proteins, polypeptides and peptides are disclosed which utilize mammalian host cells engineered for autonomous and regulated growth in low cost protein/serum-free culture media. Preferred host cells express insulin or an insulin-like growth factor, and/or transferrin and are engineered so that addition of an inducer (e.g., ZnCl2+CdCl2) halts growth and simultaneously induces the expression of the desired recombinant protein, polypeptide or peptide.
    Type: Application
    Filed: September 28, 2001
    Publication date: August 1, 2002
    Inventors: Sybille Marie Hunt, Peter Philip Gray, Merilyn Joy Sleigh
  • Regulated autocrine growth of mammalian cells
    Patent number: 6340574
    Abstract: Methods of production of desired recombinant proteins, polypeptides and peptides are disclosed which utilize mammalian host cells engineered for autonomous and regulated growth in low cost protein/serum-free culture media. Preferred host cells express insulin or an insulin-like growth factor, and/or transferrin and are engineered so that addition of an inducer (e.g., ZnCl2+CdCl2) halts growth and simultaneously induces the expression of the desired recombinant protein, polypeptide or peptide.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: January 22, 2002
    Assignees: Unisearch Limited, Commonwealth Scientific and Industrial Research Organization
    Inventors: Sybille Marie Hunt, Peter Philip Gray, Merilyn Joy Sleigh
  • Methods of treating immunopathologies using polyunsaturated fatty acids
    Patent number: 6262119
    Abstract: Method of treating or ameliorating symptoms of T-cell mediated disease wherein a composition comprising a therapeutically effective amount of a polyunsaturated fatty acid and a pharmaceutically acceptable carrier is administered to the patient. The polyunsaturated fatty acid contains 18-25 carbon atoms, 1-6 double bonds and has 1 or 2 substitutions selected from &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia, based on the fatty acid acyl carbon atom, or the polyunsaturated fatty acid contains 16-26 carbon atoms, 3-double bonds and is covalently coupled at the carboxylic acid group to an amino acid.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: July 17, 2001
    Assignees: Peptide Technology Limited, Women's and Children's Hospital Adelaide
    Inventors: Antonio Ferrante, Alfred Poulos, Michael Joseph Pitt, Christopher John Easton, Merilyn Joy Sleigh, Deborah Ann Rathjen, Fred Widmer
  • Synthetic polyunsaturated fatty acid analogues
    Patent number: 5998476
    Abstract: The invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity, or anti-inflammatory activity. The polyunsaturated fatty acids contain a 16-26 carbon chain, 3-6 double bonds and are covalently coupled at the carboxylic acid group to an amino acid. It is preferred that the fatty acid contains 18-22 carbons and that the amino acid is glycine or aspartic acid. Preferred compounds are .gamma.-linolenic acid-glycine, .alpha.-linolenic acid-glycine, arachidonic acid-aspartic acid, eicosapentaenoic acid-aspartic acid and docosahexaenoic acid-aspartic acid.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: December 7, 1999
    Assignee: Peptide Technology Limited
    Inventors: Merilyn Joy Sleigh, Fred Widmer, Paul Adam Schober, Antonio Ferrante, Alfred Poulos, Deborah Ann Rathjen