Patents by Inventor Merrill Joy Rowley

Merrill Joy Rowley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals of human glutamic acid decarboxylase 65 (GAD65)
    Patent number: 8420371
    Abstract: A crystal comprising an isoform of an N-terminally truncated glutamic acid decarboxylase (GAD) chosen from the group consisting of a monoclinic P21 space group with unit cell dimensions of a =84.05±2.3 ?, b=62.74±2.3 ?, c=101.35±2.3 ? and ? =106.69° (GAD67) or an orthorhombic C2221 space group with unit cell dimensions of a=78.25±2.3 ?, b=99.05±2.3 ? and c=120.01±2.3 ?(GAD65).
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: April 16, 2013
    Assignee: Monash University
    Inventors: James Charles Whisstock, Ashley Maurice Buckle, Gustavo Fenalti, Ruby Hong Ping Law, Merrill Joy Rowley
  • Crystal structures of both isoforms of human glutamic acid decarboxylase
    Publication number: 20100216112
    Abstract: A crystal comprising an isoform of an N-terminal truncation of GAD chosen from the group consisting of a monoclinic P2L space group with unit cell dimensions of a=84.05±2.3 ?, b=62.74±2.3 ?, c=101.35±2.3 ? and ?=106.69 (GAD65) or an orthorhombic C222L space group with unit cell dimensions of a=78.25±2.3 ?, b=99.05±2.3 ? and c=120.01±2.3 ? (GAD67).
    Type: Application
    Filed: September 13, 2007
    Publication date: August 26, 2010
    Inventors: James Charles Whisstock, Ashley Maurice Buckle, Gustavo Fenalti, Ruby Hong Ping Law, Merrill Joy Rowley
  • Expression in yeast of antigenically active, recombinant hybrid glutamic acid decarboxylase
    Patent number: 6165738
    Abstract: An antigenically active hybrid glutamic acid decarboxylase (GAD) comprising an amino-terminal moiety derived from the GAD67 isoform linked directly or indirectly with a middle and carboxy-terminal moiety derived from the GAD65 isoform, and production thereof as a recombinant protein by expression in eukaryotic host cells, particularly yeasts.
    Type: Grant
    Filed: September 13, 1999
    Date of Patent: December 26, 2000
    Assignees: Montech Medical Developments Pty. Ltd., Rondole Pty. Ltd.
    Inventors: Ian Reay Mackay, Merrill Joy Rowley, Paul Zev Zimmet, Brian Corner, Ruby Law, Khay-Lin Teoh
  • Methods for the diagnosis of diabetes and prediabetic conditions
    Patent number: 5770381
    Abstract: A method for detecting autoantibodies to glutamic acid decarboxylase (GAD) in the serum of a patient as diagnostic of a diabetic or prediabetic condition in the patient, comprises contacting a serum sample from the patient with a GAD antigen and detecting binding of autoantibodies to GAD in the sample by the GAD antigen, wherein the GAD antigen comprises a GAD preparation containing an enhanced amount of dimer(s) or oligomer(s) of the 65 kD or 67 kD isoforms, or both, of GAD. A diagnostic kit is also inclosed.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: June 23, 1998
    Assignee: Monash University
    Inventors: Ian Reay MacKay, Merrill Joy Rowley, Paul Zev Zimmet