Abstract: A cutting element assembly includes a cutter support including a cutter bore. A cutting element is in the cutter bore and a resilient element is integral with the cutter support. The resilient element is longitudinally compressible and has a displacement of greater than 0.1 mm and optionally less than 2 mm. Another cutting assembly includes a cutter support coupled to multiple cutting elements. A resilient element of the cutter support is compressible based on a force applied to the cutter support through one or more of the cutting elements. The resilient element can include a slit in the cutter support. A slit may, for instance, extend perpendicular or transverse to an axis of the cutting elements and allow the cutter support to flex and close off or reduce a size of the slit when forces act on one or more of the cutting elements.

Abstract: A bone pin clamp for external fracture fixation apparatus comprises rotation, slide and housing elements (240, 220, 210) nested one within the next, each such element being apertured to receive a pin (100) therethrough, and the rotation and slide elements respectively affording pin adjustment in azimuth and zenith, and in height, relative to the housing element, and a locking mechanism (60, 80, 170) including a common actuator member (60) operable simultaneously to lock the pin and rotation and slide elements in the housing element. In a preferred form the housing element serves as a cylinder with the slide element as a keyed piston therein, and the rotation element is a disc located between a screw (60) and annular thrust members (80, 170) engaged in the piston, the piston and disc being split respectively to lock by expansion and compaction under screw action towards the thrust members.

Abstract: A non-rigid bone fracture fixator comprising first and second bone pins for connection either side of a bone fracture and primary and secondary supports clamped to the bone pins by respective fixed and guide clamps. The second support and the guide clamps are connected slidably to the primary support such that the supports may execute a controlled degree of movement with respect to one another. A compression spring is arranged to bias apart the supports longitudinally of a fixated limb. In use the fixator is applied to the limb with the fracture in slight compression. Exercise of the limb then produces varying degrees of fracture compression stimulating bone callus formation and rapid healing. The fixator may include actuating means to provide passive fracture exercise for immobilized patients.

Abstract: A non-rigid bone fracture fixator comprising first and second bone pins for connection either side of a bone fracture and primary and secondary supports clamped to the bone pins by respective fixed and guide clamps. The second support and the guide clamps are connected slidably to the primary support such that the supports may execute a controlled degree of movement with respect to one another. A compression spring is arranged to bias apart the supports longitudinally of a fixated limb. In use the fixator is applied to the limb with the fracture in slight compression. Exercise of the limb then produces varying degrees of fracture compression stimulating bone callus formation and rapid healing. The fixator may include actuating means to provide passive fracture exercise for immobilized patients.

Abstract: A post-fracture bone immobilization splint for unilateral fixation comprises a rigid bar on which are slidably mounted at least four pin clamps. Each pin clamp is fixable to the bar and is provided with a pin to engage a part of the fractured bone. The pin is supported in two holes diametrically located in a hollow cylindrical portion of the pin clamp, the diameter of the holes being larger than the pin diameter such that the pin can be adjusted slidingly as well as azimuthally within a limited range of zenith angles. The annular gap surrounding the pin is sealed by surrounding moveable washers which are spaced apart within cylindrical portion by a plastic tube through which the pin passes. The remainder of the hollow portion is filled with small ball bearings that are compressible by a threaded plug. The pin is positioned as desired and the threaded plug is then rotated to compress the ball bearings which deform the plastic tube and thereby grip the pin.

Abstract: A reel for use upon a cylindrical support on plaster jacket bedframes incorates a ratchetless anti-reverse mechanism which is readily disengageable and which permits continuous adjustment of the position of the reel upon the bedframe. The anti-reverse mechanism comprises a close wound helical spring which has a free diameter less than the diameter of the cylindrical support. The spring is mounted on the cylindrical support and attached by one of its ends to a spool rotatably mounted on the cylindrical support.

Abstract: Compounds of the general formula (I): ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 may be the same or different and each represents a hydrogen atom, an alkyl group, a nitro group, a halogen atom or a group of the formula --NR.sub.4 R.sub.5 or --OR.sub.4 ; in which the groups R.sub.4 and R.sub.5 may be the same or different and each represent a hydrogen atom, or an alkyl, alkenyl or cycloalkyl group (which alkyl group may optionally be substituted by alkoxy, hydroxy, amino, alkylamino, dialkylamino or aryl groups) or R.sub.4 and R.sub.5 together with the nitrogen atom form a heterocyclic ring which may optionally contain additional hetero atoms, e.g. morpholino or piperazinyl; and R.sub.6 represents a hydrogen atom or an alkyl group.These compounds have biological activity, particularly in inhibiting the release of spasmogenic substances arising as a consequence of antigen-antibody reactions.

Abstract: Compounds of the general formula: ##SPC1##Wherein X represents a 5-[1H]-tetrazolyl group, R.sub.1 represents a hydrogen atom, a halogen atom, a hydroxyl group or a group --OR.sub.2, (in which R.sub.2 may be a lower alkyl or alkenyl group containing from 1 to 6 carbon atoms optionally substituted by one or more hydroxy groups, an aryl group, an aryloxy group, an alkoxy group or a dialkylamino group) or a group --NR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which may be the same or different, represent a hydrogen atom, a lower alkyl group containing from 1 to 6 carbon atoms, optionally substituted by a hydroxy group, or R.sub.3 and R.sub.4 together with the nitrogen atom may form a ring which may optionally be substituted with another heteroatom and pharmaceutically acceptable salts thereof.These compounds have useful immunological activity and inhibit the release of spasmogen mediators.

Abstract: Compounds of the general formula: ##SPC1##Wherein X represents a 5-[1H]-tetrazolyl group, R.sub.1 represents a hydrogen atom, a halogen atom, a hydroxyl group or a group --OR.sub.2, (in which R.sub.2 may be a lower alkyl or alkenyl group containing from 1 to 6 carbon atoms optionally substituted by one or more hydroxy groups, an aryl group, an aryloxy group, an alkoxy group or a dialkylamino group) or a group --NR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which may be the same or different, represent a hydrogen atom, a lower alkyl group containing from 1 to 6 carbon atoms, optionally substituted by a hydroxy group, or R.sub.3 and R.sub.4 together with the nitrogen atom may form a ring which may optionally be substituted with another heteroatom and pharmaceutically acceptable salts thereof.These compounds have useful immunological activity and inhibit the release of spasmogen mediators.

Abstract: The compound 5,5'-[(2-hydroxytrimethylene)dioxy]bis[2(1H-tetrazol-5-yl)chromone] and non-toxic pharmaceutically acceptable salts thereof.This compound inhibits the release of spasmogen from antibody-antigen reactions.

Abstract: A digital data storage element using magnetic bubbles, or small cylindrical magnetic domains formed in a thin film of magnetic material, in which binary information is stored by providing two alternative positions for a magnetic bubble, a pattern of high permeability magnetic material being provided adjacent to the surface of the film to constrain the bubble to lie in any one of the two positions. Information can be transferred from one storage element to another by the mutual repulsion effect of the magnetic bubbles. Shifting registers using two storage elements per bit are described using the mutual repulsion effect of the bubbles to effect data transfer along the register. The use of a small field pulsed with microsecond pulses superimposed on a steady field is described for encouraging the generation of bubbles.

Abstract: Compounds of the general formula (I): ##SPC1##in which R.sub.1, R.sub.2 and R.sub.3 may be the same or different and each represents a hdyrogen atom, an alkyl group, a nitro group, a halogen atom or a group of the formula --NR.sub.4 R.sub.5 or --OR.sub.4 ; in which the groups R.sub.4 and R.sub.5 may be the same or different and each represent a hydrogen atom, or an alkyl, alkenyl or cycloalkyl group (which alkyl group may optionally be substituted by alkoxy, hydroxy, amino, alkylamino, dialkylamino or aryl groups) or R.sub.4 and R.sub.5 together with the nitrogen atom form a heterocyclic ring which may optionally contain additional hetero atoms, e.g. morpholino or piperazinyl; and R.sub.6 represents a hydrogen atom or an alkyl group.These compounds have biological activity, particularly in inhibiting the release of spasmogenic substances arising as a consequence of antigen-antibody reactions.