Patents by Inventor Meryl H. Karol

Meryl H. Karol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymyxin lipopolysaccharide antigen and associated method
    Patent number: 4870158
    Abstract: Antigens that produce antibodies specific for the lipopolysaccharide or endotoxin are produced and characterized. A method of producing the antigen is disclosed. These specific antibodies may be used as immunodiagnostic agents to detect the presence of and quantity of endotoxin in samples.
    Type: Grant
    Filed: November 5, 1987
    Date of Patent: September 26, 1989
    Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
    Inventors: Meryl H. Karol, Lisa K. Ryan
  • Tolyl isocyanate and toluene diisocyanate test antigens, methods for their preparation and use in detecting diisocyanates and antibodies to diisocyanates
    Patent number: 4383984
    Abstract: An antigen and a method for its preparation and use in detecting antibody to a selected diisocyanate is provided by reacting the monoisocyanate derivative of the diisocyanate or the diisocyanate with a protein, incubating the antigen on a paper disc with test serum in the presence of a buffer and anti-IgE-.sup.125 I and thereafter counting the disc with a scintillation spectrometer.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: May 17, 1983
    Assignee: University of Pittsburgh
    Inventors: Meryl H. Karol, Yves C. Alarie
  • Tolyl isocyanate test antigens, methods for their preparation and use in detecting diisocyanates and antibodies to diisocyanates
    Patent number: 4208399
    Abstract: An antigen and a method for its preparation and use in detecting antibody to a selected diisocyanate is provided by reacting the monoisocyanate derivative of the diisocyanate with a protein, incubating the antigen on a paper disc with test serum in the presence of a buffer and anti-IgE- .sup.125 I and thereafter counting the disc in a scintillation fluid with a liquid scintillation spectrometer.
    Type: Grant
    Filed: August 16, 1978
    Date of Patent: June 17, 1980
    Assignee: The University of Pittsburgh
    Inventors: Meryl H. Karol, Yves C. Alarie