Patents by Inventor Mi Bo KIM
Mi Bo KIM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210401916Abstract: The present invention relates to a composition for preventing or treating a muscle disorder, which includes a Chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the Chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the Chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1?, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance.Type: ApplicationFiled: September 20, 2021Publication date: December 30, 2021Applicants: Industry-Academic Cooperation Foundation, Yonsei University, Cosmax NBT, Inc., Cosmax NS, Inc.Inventors: Jae Kwan HWANG, Jun Gon YUN, Mi Bo KIM, Chang Hee KIM, Joon Hyung LEE, Do Wan KWON, Su Young CHOI, Jin Hak KIM, Ji Hwan JANG, Jeong Ho GEUM, Min Son KWEON
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Patent number: 11160840Abstract: The present invention relates to a composition for preventing or treating a muscle disorder, which includes a chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1?, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance.Type: GrantFiled: November 30, 2017Date of Patent: November 2, 2021Assignees: Industry-Academic Cooperation Foundation, Yonsei University, Cosmax NBT, Inc., Cosmax NS, Inc.Inventors: Jae Kwan Hwang, Jun Gon Yun, Mi Bo Kim, Chang Hee Kim, Joon Hyung Lee, Do Wan Kwon, Su Young Choi, Jin Hak Kim, Ji Hwan Jang, Jeong Ho Geum, Min Son Kweon
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Patent number: 10960040Abstract: The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing a Platycodon grandiflorum extract. More specifically, the present invention relates to: a pharmaceutical composition for preventing and treating muscle diseases, containing a Platycodon grandiflorum extract; a food composition for preventing muscle diseases or improving muscular function; or a cosmetic for improving muscular function. The Platycodon grandiflorum extract of the present invention increases muscle formation by inducing muscular protein synthesis and muscle cell differentiation. Therefore, the extract is a natural product so as to be used safely without side effects, thereby being usable as an active ingredient of a pharmaceutical, food, or cosmetic composition exhibiting an excellent effect in preventing and treating muscle diseases or improving muscular function.Type: GrantFiled: May 26, 2016Date of Patent: March 30, 2021Assignee: NEWTREE CO., LTD.Inventors: Jae-Kwan Hwang, Mi-Bo Kim, Changhee Kim, Doun Kim, Heechul Chung
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Patent number: 10821153Abstract: Vigna angularis var. angularis according to the present invention is capable of increasing muscle mass and enhancing muscular function or exercise performance through an effect of promoting mRNA or protein expression and the activity of a gene involved in muscle functions, muscle mass increase of differentiation of muscle cells; can prevent, treat or ameliorate a decline in exercise performance, a decline in muscle function, muscle loss, etc. caused by various diseases; and may be effectively used for medicines or food products, etc., since it has no side effects in the body as natural substance.Type: GrantFiled: May 2, 2017Date of Patent: November 3, 2020Assignee: NEWTREE CO., LTD.Inventors: Jae Kwan Hwang, Se In Lee, Mi Bo Kim, Chang Hee Kim, Doun Kim, Heechul Chung, Hyeongmin Kim
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Patent number: 10646498Abstract: A composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract is disclosed. Fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.Type: GrantFiled: May 26, 2016Date of Patent: May 12, 2020Assignee: AAT COSTECH CO., LTD.Inventors: Jae Kwan Hwang, Chang Hee Kim, Mi-Bo Kim
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Patent number: 10576057Abstract: The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing, as an active ingredient, at least one selected from the group consisting of morusin, kuwanon G, and a Mori Cortex Radicis extract. The Mori Cortex Radicis extract, morusin, or kuwanon G, according to the present invention, has an effect of remarkably enhancing muscular function by increasing the expression of p-mTOR protein involved in muscular protein synthesis, inhibiting the expression of mRNAs of MuRF-1 and atrogin-1 involved in muscular protein degradation, and increasing the expression of mRNAs of MyoD and myogenin involved in muscular differentiation. In addition, the present invention is a natural product so as to be used safely without side effects, thereby being usable in drugs, food, or cosmetics.Type: GrantFiled: November 27, 2017Date of Patent: March 3, 2020Assignee: NEWTREE CO., LTD.Inventors: Jae-Kwan Hwang, Mi-Bo Kim, Changhee Kim, Doun Kim, Heechul Chung
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Publication number: 20200009208Abstract: The present invention relates to a composition for preventing or treating a muscle disorder, which includes a chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1?, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance.Type: ApplicationFiled: November 30, 2017Publication date: January 9, 2020Applicants: Industry-Academic Cooperation Foundation, Yonsei University, Cosmax NBT, Inc., Cosmax NS, Inc.Inventors: Jae Kwan HWANG, Jun Gon YUN, Mi Bo KIM, Chang Hee KIM, Joon Hyung LEE, Do Wan KWON, Su Young CHOI, Jin Hak KIM, Ji Hwan JANG, Jeong Ho GEUM, Min Son KWEON
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Patent number: 10507224Abstract: The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, a Siegesbeckia herba extract, or a fraction of the Siegesbeckia herba extract as an active ingredient. Kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an excellent effect of increasing muscle mass by increasing the protein expression of p-mTOR, which is a major gene concerned with muscle functions. Also, kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1?, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.Type: GrantFiled: December 27, 2016Date of Patent: December 17, 2019Assignee: AAT Costech Co., Ltd.Inventors: Jae-Kwan Hwang, Mi-Bo Kim, Chang Hee Kim
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Publication number: 20190183811Abstract: The present invention relates to a composition for preventing, treating, or ameliorating muscle disease or regenerating damaged muscles, comprising squalene. More specifically, the squalene of the present invention increases expression of proteins which are associated with muscle protein synthesis and muscle mass increase in muscle cells, inhibits, at an mRNA level, expression of enzymes involved in muscle protein degradation, and has an effect of rapidly restoring damaged muscles. In addition, the present invention relating to a natural product can be safely used without side effects, and thus can be used as medicines, foods, or cosmetics.Type: ApplicationFiled: August 3, 2017Publication date: June 20, 2019Applicant: AAT COSTECH CO., LTD.Inventors: Jae Kwan HWANG, Se In LEE, Mi Bo KIM, Chang Hee KIM
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Publication number: 20190142897Abstract: Vigna angularis var. angularis according to the present invention is capable of increasing muscle mass and enhancing muscular function or exercise performance through an effect of promoting mRNA or protein expression and the activity of a gene involved in muscle functions, muscle mass increase of differentiation of muscle cells; can prevent, treat or ameliorate a decline in exercise performance, a decline in muscle function, muscle loss, etc. caused by various diseases; and may be effectively used for medicines or food products, etc., since it has no side effects in the body as natural substance.Type: ApplicationFiled: May 2, 2017Publication date: May 16, 2019Inventors: Jae Kwan HWANG, Se In LEE, Mi Bo KIM, Chang Hee KIM, Doun KIM, Heechul CHUNG, Hyeongmin KIM
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Publication number: 20190070129Abstract: The present invention relates to use of a composition comprising a panduratin derivative or a boesenbergia pandurata extract as an effective ingredient, which suppresses the differentiation of osteoclasts to exhibit the effect of treating, preventing or ameliorating bone loss diseases and which can be used safely as a natural material without side effects, thus finding effective applications in drugs, quasi-drugs, or foods.Type: ApplicationFiled: August 28, 2018Publication date: March 7, 2019Inventors: Jae Kwan Hwang, Si Yeon Kim, Mi Bo Kim
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Publication number: 20180318320Abstract: The present invention relates to a composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract. According to the present invention, fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function.Type: ApplicationFiled: May 26, 2016Publication date: November 8, 2018Inventors: Jae Kwan HWANG, Chang Hee KIM, Mi-Bo KIM
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Publication number: 20180193396Abstract: The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing a Platycodon grandiflorum extract. More specifically, the present invention relates to: a pharmaceutical composition for preventing and treating muscle diseases, containing a Platycodon grandiflorum extract; a food composition for preventing muscle diseases or improving muscular function; or a cosmetic for improving muscular function. The Platycodon grandiflorum extract of the present invention increases muscle formation by inducing muscular protein synthesis and muscle cell differentiation. Therefore, the extract is a natural product so as to be used safely without side effects, thereby being usable as an active ingredient of a pharmaceutical, food, or cosmetic composition exhibiting an excellent effect in preventing and treating muscle diseases or improving muscular function.Type: ApplicationFiled: May 26, 2016Publication date: July 12, 2018Inventors: Jae-Kwan Hwang, Mi-Bo Kim, Changhee Kim, Doun Kim, Heechul Chung
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Publication number: 20180153852Abstract: The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing, as an active ingredient, at least one selected from the group consisting of morusin, kuwanon G, and a Mori Cortex Radicis extract. The Mori Cortex Radicis extract, morusin, or kuwanon G, according to the present invention, has an effect of remarkably enhancing muscular function by increasing the expression of p-mTOR protein involved in muscular protein synthesis, inhibiting the expression of mRNAs of MuRF-1 and atrogin-1 involved in muscular protein degradation, and increasing the expression of mRNAs of MyoD and myogenin involved in muscular differentiation. In addition, the present invention is a natural product so as to be used safely without side effects, thereby being usable in drugs, food, or cosmetics.Type: ApplicationFiled: November 27, 2017Publication date: June 7, 2018Inventors: Jae-Kwan HWANG, Mi-Bo KIM, Changhee KIM, Doun KIM, Heechul CHUNG
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Patent number: 9956157Abstract: The present invention relates to a novel use of fucosterol and, more specifically, to a composition for skin whitening or composition for skin moisturizing, which is characterized by containing fucosterol. Fucosterol of chemical formula 1 below has an excellent whitening effect of inhibiting melanin generation and tyrosinase activity, and thus can be used as an active ingredient of a cosmetic composition for whitening, a food composition, or a pharmaceutical composition.Type: GrantFiled: January 23, 2015Date of Patent: May 1, 2018Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITYInventors: Jae Kwan Hwang, Seon Wook Woo, Chang Hee Kim, Mi Bo Kim
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Publication number: 20170182106Abstract: The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, a Siegesbeckia herba extract, or a fraction of the Siegesbeckia herba extract as an active ingredient. Kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an excellent effect of increasing muscle mass by increasing the protein expression of p-mTOR, which is a major gene concerned with muscle functions. Also, kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1?, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.Type: ApplicationFiled: December 27, 2016Publication date: June 29, 2017Inventors: Jae-Kwan HWANG, Mi-Bo Kim, Chang Hee Kim
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Publication number: 20170000714Abstract: The present invention relates to a novel use of fucosterol and, more specifically, to a composition for skin whitening or composition for skin moisturizing, which is characterized by containing fucosterol. Fucosterol of chemical formula 1 below has an excellent whitening effect of inhibiting melanin generation and tyrosinase activity, and thus can be used as an active ingredient of a cosmetic composition for whitening, a food composition, or a pharmaceutical composition.Type: ApplicationFiled: January 23, 2015Publication date: January 5, 2017Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITYInventors: Jae Kwan HWANG, Seon Wook WOO, Chang Hee KIM, Mi Bo KIM