Patents by Inventor Mi-Kyung Yun
Mi-Kyung Yun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11891378Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: December 26, 2018Date of Patent: February 6, 2024Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., COA THERAPEUTICS, INC.Inventors: Richard E. Lee, Rajendra P. Tangallapally, Charles O. Rock, Suzanne Jackowski, Anne V. Edwards, Mi Kyung Yun, Chitra Subramanian, Robert Zamboni, T. Jagadeeswar Reddy
-
Publication number: 20230321092Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: December 6, 2022Publication date: October 12, 2023Inventors: Suzanne JACKOWSKI, Charles O. ROCK, Richard E. LEE, Lalit Kumar SHARMA, Mi Kyung YUN, Chitra SUBRAMANIAN, Rajendra P. TANGALLAPALLY, Anne V. EDWARDS, Robert ZAMBONI, T. Jagadeeswar REDDY, Jiuyu LIU
-
Patent number: 11547709Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: December 26, 2018Date of Patent: January 10, 2023Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., COA THERAPEUTICS, INC.Inventors: Suzanne Jackowski, Charles O. Rock, Richard E. Lee, Lalit Kumar Sharma, Mi Kyung Yun, Chitra Subramanian, Rajendra P. Tangallapally, Anne V. Edwards, Robert Zamboni, T. Jagadeeswar Reddy, Jiuyu Liu
-
Publication number: 20220185796Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: March 26, 2020Publication date: June 16, 2022Inventors: Ragendra P. Tangallapally, Richard E. Lee, Anne V. Edwards, Charles O. Rock, Suzanne Jackowski, Mi Kyung Yun, Chitra Subramanian
-
Publication number: 20210246113Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: December 14, 2020Publication date: August 12, 2021Inventors: Lalit Kumar SHARMA, Richard E. LEE, Charles O. ROCK, Suzanne JACKOWSKI, Mi Kyung YUN, Chitra SUBRAMANIAN, Jiuyu LIU
-
Publication number: 20210061788Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: December 26, 2018Publication date: March 4, 2021Inventors: Richard E. LEE, Rajendra P. TANGALLAPALLY, Charles O. ROCK, Suzanne JACKOWSKI, Anne V. EDWARDS, Mi Kyung YUN, Chitra SUBRAMANIAN, Robert ZAMBONI, T. Jagadeeswar REDDY
-
Publication number: 20210023081Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: December 26, 2018Publication date: January 28, 2021Inventors: Suzanne JACKOWSKI, Charles O. ROCK, Richard E. LEE, Lalit Kumar SHARMA, Mi Kyung YUN, Chitra SUBRAMANIAN, Rajendra P. TANGALLAPALLY, Anne V. EDWARDS, Robert ZAMBONI, T. Jagadeeswar REDDY, Jiuyu LIU
-
Patent number: 10899734Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: June 23, 2017Date of Patent: January 26, 2021Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.Inventors: Lalit Kumar Sharma, Richard E. Lee, Charles O. Rock, Suzanne Jackowski, Mi Kyung Yun, Chitra Subramanian, Jiuyu Liu
-
Publication number: 20190300499Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: June 23, 2017Publication date: October 3, 2019Applicant: St. Jude Children's Research HospitalInventors: Lalit Kumar Sharma, Richard E. Lee, Charles O. Rock, Suzanne Jackowski, Mi Kyung Yun, Chitra Subramanian, Jiuyu Liu
-
Patent number: 6618457Abstract: A method for receiving an external signal in synchronization with rising and falling edges of a data strobe signal to generate two internal signals in synchronization with one of both edges of a main clock in a high speed memory device, includes the steps of receiving the external signal to generate a full-swing level signal, dividing the full-swing level signal into a first signal and a second signal in synchronization with the data strobe signal, wherein the first signal is activated in synchronization with rising edges of the data strobe signal and the second signal is activated in synchronization with falling edges of the data strobe signal, aligning the first signal and the second signal with one of both edges of the data strobe signal, and aligning the aligned first and second signals with one of both edges of a main clock.Type: GrantFiled: December 20, 1999Date of Patent: September 9, 2003Assignee: Hyundai Electronics Industries Co., Ltd.Inventors: Seung-Hyun Yi, Mi-Kyung Yun
-
Patent number: 6449674Abstract: An internal command signal generator and a method therefor generate internal command signal for an internal circuit operation after receiving external control signal in a synchronous memory device. Particularly, the internal command signal generator and a method therefor previously decode external input control signals for generating an internal command signal during a time required to generate an internal clock signal by buffering the external clock signal, thus produce an internal command signal, and synchronize the internal command signal to the internal clock signal. As a result, all time required to a decoding operation is reduced so that a data access time is greatly reduced.Type: GrantFiled: December 23, 1999Date of Patent: September 10, 2002Assignee: Hyundai Electronics Industries Co., Ltd.Inventors: Mi Kyung Yun, Jong Hee Han
-
Patent number: 6201760Abstract: A method for performing a read data operation in a double data rate (DDR) synchronous dynamic random access memory (SDRAM) capable of effectively issuing two data within one clock cycle for high-speed operation. The method includes the steps of simultaneously accessing two memory cells and prefetching data stored in the two memory cells, which includes first and second bit data. The method continues by latching the first and second bit data, generating signals to synchronize the first and second bit data with rising and falling edges of a clock and to control an issue of the first and second bit data, and issuing the first and second bit data in response to the generated signals.Type: GrantFiled: December 16, 1999Date of Patent: March 13, 2001Assignee: Hyundai Electronics Industries Co., Ltd.Inventors: Mi-Kyung Yun, Jong-Hee Han
-
Patent number: 6166970Abstract: Disclosed is a DDR SDRAM device capable of inputting and outputting a plurality of data within one period of a clock; and, more particularly, a priority determining apparatus for determining data output priority between even and odd data. The DDR SDRAM device according to the present invention includes a priority signal generator for receiving a least significant bit of a column address signal and a first control signal which is activated when read or write operation is carried out and for generating a priority signal to determine an order of output of the even and odd data stored in each of the pipeline latch circuits.Type: GrantFiled: December 30, 1999Date of Patent: December 26, 2000Assignee: Hyundai Electronics Industries Co., Ltd.Inventor: Mi-Kyung Yun
-
Patent number: 5985899Abstract: The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R.sup.1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group,X represents a group of formula ##STR2## R.sup.2 and R.sup.3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, orR.sup.2 and R.sup.3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl,R.sup.4 represents hydrogen, lower alkyl or lower alkoxy,R.sup.Type: GrantFiled: November 10, 1997Date of Patent: November 16, 1999Assignee: LG Chemical Ltd.Inventors: Yeong Soo Oh, Sang Soo Kim, Sang Yeul Hwang, Mi Kyung Yun, Seong Ryul Hwang, Seong Won Hong, Yong Hee Lee, Yi Na Jeong, Koo Lee, You Seung Shin
-
Patent number: 5977114Abstract: The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R.sup.1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group,x represents a group of formula ##STR2## R.sup.2 and R.sup.3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, orR.sup.2 and R.sup.3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl,R.sup.4 represents hydrogen, lower alkyl or lower alkoxy,R.sup.Type: GrantFiled: November 10, 1997Date of Patent: November 2, 1999Assignee: LG Chemical Ltd.Inventors: Yeong Soo Oh, Sang Soo Kim, Sang Yeul Hwang, Mi Kyung Yun, Seong Ryul Hwang, Seong Won Hong, Yong Hee Lee, Yi Na Jeong, Koo Lee, You Seung Shin
-
Patent number: 5747535Abstract: The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R.sup.1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group,X represents a group of formula ##STR2## R.sup.2 and R.sup.3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, orR.sup.2 and R.sup.3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl,R.sup.4 represents hydrogen, lower alkyl or lower alkoxy,R.sup.Type: GrantFiled: January 16, 1996Date of Patent: May 5, 1998Assignee: LG Chemical Ltd.Inventors: Yeong Soo Oh, Sang Soo Kim, Sang Yeul Hwang, Mi Kyung Yun, Seong Ryul Hwang, Seong Won Hong, Yong Hee Lee, Yi Na Jeong, Koo Lee, You Seung Shin